TIE1 - tyrosine kinase with immunoglobulin like and EGF like domains 1 Gene

Homo sapiens

Also known as TIE; JTK14; LMPHM11

Gene ID: 7075 | Gene type: protein coding

About TIE1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,300,982-43,323,108 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues, 53 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 23.3), fat (RPKM 19.2) and 21 other tissues.

Summary

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

TIE1 Products(2)

mRNA	Protein	Name
NM_001253357.2	NP_001240286.1	tyrosine-protein kinase receptor Tie-1 isoform 2
NM_005424.5	NP_005415.1	tyrosine-protein kinase receptor Tie-1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIE1 Protein Structure

Ig_2

hEGF

Ig_2

fn3

Pkinase_Tyr

0
200
400
600
800
1000
1138 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase receptor Tie-1

tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1

Recombinant TIE1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71362	TIE-1 Protein, Human (HEK293, His)	P35590 (A22-Q760)	≥95%

Related Diseases

Diseases

Alias

Lymphatic Malformation 11

LMPHM11

Angiosarcoma

Hemangiosarcoma

Malignant Renovascular Hypertension

Secondary Malignant Renovascular Hypertension

Primary Lymphedema

Lymphedema Primary

Inflammatory Breast Carcinoma

Inflammatory Breast Cancer	Inflammatory Carcinoma Of Breast
Mastitis Carcinomatosa	Breast Cancer, Inflammatory
Inflammatory Breast Neoplasms	Inflammatory Adenocarcinoma Of Breast

Breast Angiosarcoma

Angiosarcoma Of The Breast	Hemangiosarcoma Of The Breast
Primary Angiosarcoma Of Breast

Periodontosis

Periodontitis, Juvenile	Parodontosis
Paradentosis

Lymphangiosarcoma

Skin Lymphangiosarcoma	Stewart Treves Syndrome
Lymphangiosarcoma Of Stewart And Treves	Malignant Lymphangioendothelioma
Stewart-Treves Syndrome

Hemangioma

Hemangiomas

Malignant Secondary Hypertension

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14514	TIAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14520	TIE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TIE1	VGNC	VGNC:47366
Mus musculus	TIE1	MGD	MGI:99906
Bos taurus	TIE1	VGNC	VGNC:35861
Rattus norvegicus	TIE1	RGD	RGD:621642
Felis catus	TIE1	VGNC	VGNC:80380
Macaca mulatta	TIE1	VGNC	VGNC:78355
Others	TIE1	NCBI

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