1. Gene
  2. TRPM2 - transient receptor potential cation channel subfamily M member 2 Gene

TRPM2 - transient receptor potential cation channel subfamily M member 2 Gene

Homo sapiens

Also known as KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; LTrpC-2; NUDT9L1

Gene ID: 7226 | Gene type: protein coding

About TRPM2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,353,621-44,442,644 (from NCBI)

This gene has 7 transcripts (splice variants), 243 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 4.5), brain (RPKM 2.6) and 21 other tissues.

Summary

The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

TRPM2 Products(4)

mRNA Protein Name
NM_001320350.2 NP_001307279.2 transient receptor potential cation channel subfamily M member 2 isoform 2
NM_001320351.2 NP_001307280.2 transient receptor potential cation channel subfamily M member 2 isoform 3
NM_001320352.3 NP_001307281.1 transient receptor potential cation channel subfamily M member 2 isoform 4
NM_003307.4 NP_003298.2 transient receptor potential cation channel subfamily M member 2 isoform 1

TRPM2 Protein Structure

Ion_trans

Ion_trans: Ion transport protein (831 - 1047)

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  • 1503 a.a.
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 2

estrogen-responsive element-associated gene 1 protein

Related Diseases

Diseases Alias
Calcific Tendinitis

Calcific Tendinitis Nos

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus TRPM2 VGNC VGNC:36389
Felis catus TRPM2 VGNC VGNC:66588
Macaca mulatta TRPM2 VGNC VGNC:78655
Mus musculus TRPM2 MGD MGI:1351901
Rattus norvegicus TRPM2 RGD RGD:1311889