TRPM2 - transient receptor potential cation channel subfamily M member 2 Gene

Homo sapiens

Also known as KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; LTrpC-2; NUDT9L1

Gene ID: 7226 | Gene type: protein coding

About TRPM2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,353,621-44,442,644 (from NCBI)

This gene has 7 transcripts (splice variants), 243 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 4.5), brain (RPKM 2.6) and 21 other tissues.

Summary

The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

TRPM2 Products(4)

mRNA	Protein	Name
NM_001320350.2	NP_001307279.2	transient receptor potential cation channel subfamily M member 2 isoform 2
NM_001320351.2	NP_001307280.2	transient receptor potential cation channel subfamily M member 2 isoform 3
NM_001320352.3	NP_001307281.1	transient receptor potential cation channel subfamily M member 2 isoform 4
NM_003307.4	NP_003298.2	transient receptor potential cation channel subfamily M member 2 isoform 1

TRPM2 Protein Structure

Ion_trans

0
300
600
900
1200
1503 a.a.

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily M member 2

estrogen-responsive element-associated gene 1 protein

Related Diseases

Diseases

Alias

Calcific Tendinitis

Calcific Tendinitis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14600	Rosiglitazone maleate		99.88%	Yes
HY-14600R	Rosiglitazone maleate (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100973A	Adenosine 5′-diphosphoribose sodium		99.03%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101507	Pico145	Inhibitor	99.40%	Unkown
HY-110220	CIM0216	Agonist	99.94%	Unkown
HY-149143	JNJ-28583113	Inhibitor	98.06%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-113037C	Farnesyl Pyrophosphate ammonium	Agonist	≥97.0%	Unkown
HY-N7395	Cyclic ADP-ribose	Activator	≥96.0%	Unkown
HY-N7395A	Cyclic ADP-ribose ammonium	Activator	≥99.0%	Unkown
HY-113037	Farnesyl pyrophosphate	Agonist	/	Unkown
HY-123245	Scalaradial		/	Unkown
HY-P5883	TAT-M2NX	Inhibitor	/	Unkown
HY-RS15112	TRPM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-117804	8-Br-cADPR	Antagonist	/	Unkown
HY-134268	8-Br-7-CH-ADPR	Antagonist	/	Unkown
HY-137704	2′-Deoxy-ADPR	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRPM2	VGNC	VGNC:36389
Felis catus	TRPM2	VGNC	VGNC:66588
Macaca mulatta	TRPM2	VGNC	VGNC:78655
Mus musculus	TRPM2	MGD	MGI:1351901
Rattus norvegicus	TRPM2	RGD	RGD:1311889

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