1. Gene
  2. TTC1 - tetratricopeptide repeat domain 1 Gene

TTC1 - tetratricopeptide repeat domain 1 Gene

Homo sapiens

Also known as TPR1

Gene ID: 7265 | Gene type: protein coding

About TTC1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,009,139-160,065,543 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and 18 paralogues. Ubiquitous expression in brain (RPKM 29.2), heart (RPKM 23.5) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TTC1 Products(2)

mRNA Protein Name
NM_001282500.2 NP_001269429.1 tetratricopeptide repeat protein 1
NM_003314.3 NP_003305.1 tetratricopeptide repeat protein 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9383998 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC1 Protein Structure

TPR_11

TPR_11: TPR repeat (118 - 186)

TPR_1

TPR_1: Tetratricopeptide repeat (191 - 221)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

tetratricopeptide repeat protein 1

TPR repeat protein 1

TTC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TTC1 Q99614 RNF41 Homo sapiens Q9H4P4
Anti Tag CoIP
28514442
Intra TTC1 Q99614 RNF41 Homo sapiens Q9H4P4
Anti Tag CoIP
33961781
Intra TTC1 Q99614 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra TTC1 Q99614 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra TTC1 Q99614 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
25416956
Intra TTC1 Q99614 RNF41 Homo sapiens Q9H4P4
Anti Tag CoIP
25036637
Intra TTC1 Q99614 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra TTC1 Q99614 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra TTC1 Q99614 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra TTC1 Q99614 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra TTC1 Q99614 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra TTC1 Q99614 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra TTC1 Q99614 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra TTC1 Q99614 CYB5R1 Homo sapiens Q9UHQ9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 75

RP75

Retinitis Pigmentosa, Type 75

Siberian Tick Typhus

North Asian Tick Typhus

Manchurian Typhus

North Asian Tick Fever

Rickettsia Sibirica Spotted Fever

Spotted Fever Group Rickettsiosis

Lipofibromatosis-Like Neural Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta TTC1 VGNC VGNC:78667
Mus musculus TTC1 MGD MGI:1914077
Bos taurus TTC1 VGNC VGNC:36453
Felis catus TTC1 VGNC VGNC:66650
Canis familiaris TTC1 VGNC VGNC:47936
Rattus norvegicus TTC1 RGD RGD:1359604
Others TTC1 NCBI