UBE2H - ubiquitin conjugating enzyme E2 H Gene

Homo sapiens

Also known as GID3; UBC8; UBCH; UBCH2; E2-20K

Gene ID: 7328 | Gene type: protein coding

About UBE2H

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:129,830,732-129,952,960 (from NCBI)

This gene has 10 transcripts (splice variants), 214 orthologues and 24 paralogues. Ubiquitous expression in heart (RPKM 38.0), adrenal (RPKM 36.4) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

UBE2H Products(3)

mRNA	Protein	Name
NM_001202498.2	NP_001189427.1	ubiquitin-conjugating enzyme E2 H isoform 3
NM_003344.4	NP_003335.1	ubiquitin-conjugating enzyme E2 H isoform 1
NM_182697.3	NP_874356.1	ubiquitin-conjugating enzyme E2 H isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20028976	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20061386	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2H Protein Structure

UQ_con

0
100
183 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 H

(E3-independent) E2 ubiquitin-conjugating enzyme H

UBE2H Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBE2H	P62256	GNB2	Homo sapiens	P62879	Y2H Array	32814053
Intra	UBE2H	P62256	GNB2	Homo sapiens	P62879	Y2H Pooling	32814053
Intra	UBE2H	P62256	GNB2	Homo sapiens	P62879	Validated Y2H	32814053
Intra	UBE2H	P62256	MAGEA2	Homo sapiens	P43356	Pull Down	20864041
Intra	UBE2H	P62256	MAGEC2	Homo sapiens	Q9UBF1	Anti Tag CoIP	20864041
Intra	UBE2H	P62256	MAGEC2	Homo sapiens	Q9UBF1	Ubiquitinase Assay	20864041

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2H Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71402	UBE2H Protein, Human (GST)	P62256 (M1-L183)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15348	UBE2H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	UBE2H	VGNC	VGNC:48054
Rattus norvegicus	UBE2H	RGD	RGD:2319288
Macaca mulatta	UBE2H	VGNC	VGNC:78696
Mus musculus	UBE2H	MGD	MGI:104632
Bos taurus	UBE2H	VGNC	VGNC:36583
Others	UBE2H	NCBI

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