2. Gene
  3. UBE2L3 - ubiquitin conjugating enzyme E2 L3 Gene

UBE2L3 - ubiquitin conjugating enzyme E2 L3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as E2-F1; L-UBC; UBCH7; UbcM4

Gene ID: 7332 | Gene type: protein coding

About UBE2L3

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:21,549,447-21,624,034 (from NCBI)

This gene has 5 transcripts (splice variants), 159 orthologues, 12 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 19.5), urinary bladder (RPKM 19.0) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

UBE2L3 Products(3)

mRNA Protein Name
NM_001256355.1 NP_001243284.1 ubiquitin-conjugating enzyme E2 L3 isoform 4
NM_001256356.2 NP_001243285.1 ubiquitin-conjugating enzyme E2 L3 isoform 3
NM_003347.4 NP_003338.1 ubiquitin-conjugating enzyme E2 L3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9990509 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
15367689 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
20061386 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
11278816 GOA
enables ubiquitin-protein transferase activator activity IGI
IGI: Inferred from genetic interaction
12628165 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
14765125 GOA
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
10888878 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
18946090 GOA
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
18946090 GOA
involved in cellular response to glucocorticoid stimulus IDA
IDA: Inferred from direct assay
17003263 GOA
involved in cellular response to steroid hormone stimulus IMP
IMP: Inferred from mutant phenotype
15367689 GOA
involved in positive regulation of protein ubiquitination IGI
IGI: Inferred from genetic interaction
12628165 GOA
involved in positive regulation of ubiquitin-protein transferase activity IGI
IGI: Inferred from genetic interaction
12628165 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
10888878 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
9990509 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17003263 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15367689 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9990509 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11278816 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2L3 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (6 - 142)

  • 0
  • 100
  • 154 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 L3

E2 ubiquitin-conjugating enzyme L3

UBE2L3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBE2L3 P68036 RNF182 Homo sapiens Q8N6D2
Y2H Prey Pooling
32296183
Intra
UBE2L3 P68036 RNF182 Homo sapiens Q8N6D2
Validated Y2H
32296183
Intra
UBE2L3 P68036 RNF182 Homo sapiens Q8N6D2
Y2H Array
32296183
Intra
UBE2L3 P68036 MID1 Homo sapiens O15344
Y2H Prey Pooling
32296183
Intra
UBE2L3 P68036 MID1 Homo sapiens O15344
Y2H Array
32296183
Intra
UBE2L3 P68036 RBCK1 Homo sapiens Q9BYM8
Y2H Array
19549727
Intra
UBE2L3 P68036 RBCK1 Homo sapiens Q9BYM8
Y2H Prey Pooling
32296183
Intra
UBE2L3 P68036 RBCK1 Homo sapiens Q9BYM8
Validated Y2H
32296183
Intra
UBE2L3 P68036 RBCK1 Homo sapiens Q9BYM8
Y2H Array
32296183
Intra
UBE2L3 P68036 RNF144A Homo sapiens P50876
Y2H Prey Pooling
32296183
Intra
UBE2L3 P68036 RNF144A Homo sapiens P50876
Y2H Array
32296183
Intra
UBE2L3 P68036 RNF19B Homo sapiens Q6ZMZ0
Anti Bait CoIP
16709802
Intra
UBE2L3 P68036 ARIH2 Homo sapiens O95376
Anti Tag CoIP
33961781
Intra
UBE2L3 P68036 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Intra
UBE2L3 P68036 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
Intra
UBE2L3 P68036 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2L3 Proteins

Cat. No. Product Name Accession Purity
HY-P79451 UbcH7/UBE2L3 Protein, Human P68036-1 (M1-D154) ≥95%

UBE2L3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83558 Ubiquitin Conjugating Enzyme E2 L3 Antibody (YA3303) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Papilloma

Papillomatosis
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome
Glycogen Storage Disease Iv

Gsd Iv

Glycogen Branching Enzyme Deficiency

Andersen Disease

Amylopectinosis

Glycogen Storage Disease Type Iv

GSD4

Brancher Deficiency

Glycogen Storage Disease, Type Iv

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

Gbe1 Deficiency

Glycogenosis Iv

Cirrhosis, Familial, With Deposition Of Abnormal Glycogen

Glycogen Storage Disease Type 4

Glycogenosis 4

Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, And Dysmorphic Features

Andersen'S Disease

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

Brancher Deficiency Glycogenosis

Branching-Transferase Deficiency Glycogenosis

Deficiency Of 1,4-Alpha-Glucan Branching Enzyme

Andersen-Tawil Syndrome

Gsd 4

Andersen Cardiodysrhythmic Periodic Paralysis

Lqt7

Long Qt Syndrome 7

Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type

Andersen Glycogenosis

Branching Enzyme Deficiency

Glycogenosis, Type Iv

Gsd Type Iv

Type Iv Glycogenosis

Gbe Deficiency, Childhood Neuromuscular Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

Gsd Type 4, Childhood Neuromuscular Form

Gsdiv, Childhood Neuromuscular Form

Glycogen Storage Disease Type 4, Childhood Neuromuscular Form

Glycogen Storage Disease Type Iv, Childhood Neuromuscular Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

Glycogenosis Type 4, Childhood Neuromuscular Form

Glycogenosis Type Iv, Childhood Neuromuscular Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

Gbe Deficiency, Adult Neuromuscular Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

Gsd Type 4, Adult Neuromuscular Form

Gsdiv, Adult Neuromuscular Form

Glycogen Storage Disease Type 4, Adult Neuromuscular Form

Glycogen Storage Disease Type Iv, Adult Neuromuscular Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

Glycogenosis Type 4, Adult Neuromuscular Form

Glycogenosis Type Iv, Adult Neuromuscular Form

Gbe Deficiency, Congenital Neuromuscular Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

Gsd Type 4, Congenital Neuromuscular Form

Gsdiv, Congenital Neuromuscular Form

Glycogen Storage Disease Type 4, Congenital Neuromuscular Form

Glycogen Storage Disease Type Iv, Congenital Neuromuscular Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

Glycogenosis Type 4, Congenital Neuromuscular Form

Glycogenosis Type Iv, Congenital Neuromuscular Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

Gbe Deficiency, Childhood Combined Hepatic And Myopathic Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

Gsd Type 4, Childhood Combined Hepatic And Myopathic Form

Gsdiv, Childhood Combined Hepatic And Myopathic Form

Glycogen Storage Disease Type 4, Childhood Combined Hepatic And Myopathic Form

Glycogen Storage Disease Type Iv, Childhood Combined Hepatic And Myopathic Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

Glycogenosis Type 4, Childhood Combined Hepatic And Myopathic Form

Glycogenosis Type Iv, Childhood Combined Hepatic And Myopathic Form

Gbe Deficiency, Fatal Perinatal Neuromuscular Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

Gsd Type 4, Fatal Perinatal Neuromuscular Form

Gsdiv, Fatal Perinatal Neuromuscular Form

Glycogen Storage Disease Type 4, Fatal Perinatal Neuromuscular Form

Glycogen Storage Disease Type Iv, Fatal Perinatal Neuromuscular Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

Glycogenosis Type 4, Fatal Perinatal Neuromuscular Form

Glycogenosis Type Iv, Fatal Perinatal Neuromuscular Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

Gbe Deficiency, Non Progressive Hepatic Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

Gsd Type 4, Non Progressive Hepatic Form

Gsdiv, Non Progressive Hepatic Form

Glycogen Storage Disease Type 4, Non Progressive Hepatic Form

Glycogen Storage Disease Type Iv, Non Progressive Hepatic Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

Glycogenosis Type 4, Non Progressive Hepatic Form

Glycogenosis Type Iv, Non Progressive Hepatic Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

Gbe Deficiency, Progressive Hepatic Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

Gsd Type 4, Progressive Hepatic Form

Gsdiv, Progressive Hepatic Form

Glycogen Storage Disease Type 4, Progressive Hepatic Form

Glycogen Storage Disease Type Iv, Progressive Hepatic Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

Glycogenosis Type 4, Progressive Hepatic Form

Glycogenosis Type Iv, Progressive Hepatic Form

Glycogen Storage Disease 4

Gsd-Iv

Storage Disease, Glycogen, Type Iv
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15341 UBE2D3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15344 UBE2E3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15353 UBE2L3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBE2L3 RGD RGD:1308361
Bos taurus UBE2L3 VGNC VGNC:53927
Mus musculus UBE2L3 MGD MGI:109240
Others UBE2L3 NCBI