UCK2 - uridine-cytidine kinase 2 Gene

Homo sapiens

Also known as UK; UMPK; TSA903

Gene ID: 7371 | Gene type: protein coding

About UCK2

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:165,827,614-165,911,618 (from NCBI)

This gene has 9 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 6.8), small intestine (RPKM 6.1) and 25 other tissues.

Summary

This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

UCK2 Products(2)

mRNA	Protein	Name
NM_001363568.2	NP_001350497.1	uridine-cytidine kinase 2 isoform 2
NM_012474.5	NP_036606.2	uridine-cytidine kinase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytidine kinase activity	IDA IDA: Inferred from direct assay	11306702	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15130468	GOA
enables uridine kinase activity	IDA IDA: Inferred from direct assay	11306702	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CTP salvage	IDA IDA: Inferred from direct assay	11306702	GOA
involved in UMP salvage	IDA IDA: Inferred from direct assay	11306702	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCK2 Protein Structure

PRK

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

uridine-cytidine kinase 2

cytidine monophosphokinase 2

UCK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UCK2	Q9BZX2	UCK2	Homo sapiens	Q9BZX2	Y2H Prey Pooling	32296183
Intra	UCK2	Q9BZX2	VARS2	Homo sapiens	Q5ST30	Anti Tag CoIP	33961781
Intra	UCK2	Q9BZX2	VARS2	Homo sapiens	Q5ST30	Anti Tag CoIP	28514442
Intra	UCK2	Q9BZX2	IAH1	Homo sapiens	Q2TAA2	Anti Tag CoIP	33961781
Intra	UCK2	Q9BZX2	IAH1	Homo sapiens	Q2TAA2	Anti Tag CoIP	28514442
Intra	UCK2	Q9BZX2	TSC22D1	Homo sapiens	Q15714	Anti Bait CoIP	17353931
Intra	UCK2	Q9BZX2	UCK2	Homo sapiens	Q9BZX2	Validated Y2H	32296183
Intra	UCK2	Q9BZX2	UCK1	Homo sapiens	Q9HA47	Anti Tag CoIP	33961781
Intra	UCK2	Q9BZX2	UCKL1	Homo sapiens	Q9NWZ5	Anti Tag CoIP	33961781
Intra	UCK2	Q9BZX2	UCK2	Homo sapiens	Q9BZX2	Y2H Array	32296183
Intra	UCK2	Q9BZX2	UCK1	Homo sapiens	Q9HA47	Anti Tag CoIP	28514442
Intra	UCK2	Q9BZX2	UCKL1	Homo sapiens	Q9NWZ5	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148394	UCK2 Inhibitor-1	Inhibitor	96.33%	Unkown
HY-78574	N-Benzoylcytidine		≥98.0%	Unkown
HY-148395	UCK2 Inhibitor-2	Inhibitor	/	Unkown
HY-148396	UCK2 Inhibitor-3		/	Unkown
HY-RS15404	UCK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UCK2	VGNC	VGNC:78718
Felis catus	UCK2	VGNC	VGNC:66797
Canis familiaris	UCK2	VGNC	VGNC:56145
Mus musculus	UCK2	MGD	MGI:1931744
Rattus norvegicus	UCK2	RGD	RGD:620742
Bos taurus	UCK2	VGNC	VGNC:36635
Others	UCK2	NCBI

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