2. Gene
  3. UCK2 - uridine-cytidine kinase 2 Gene

UCK2 - uridine-cytidine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as UK; UMPK; TSA903

Gene ID: 7371 | Gene type: protein coding

About UCK2

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:165,827,614-165,911,618 (from NCBI)

This gene has 9 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 6.8), small intestine (RPKM 6.1) and 25 other tissues.

Summary

This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

UCK2 Products(2)

mRNA Protein Name
NM_001363568.2 NP_001350497.1 uridine-cytidine kinase 2 isoform 2
NM_012474.5 NP_036606.2 uridine-cytidine kinase 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cytidine kinase activity IDA
IDA: Inferred from direct assay
11306702 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15130468 GOA
enables uridine kinase activity IDA
IDA: Inferred from direct assay
11306702 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CTP salvage IDA
IDA: Inferred from direct assay
11306702 GOA
involved in UMP salvage IDA
IDA: Inferred from direct assay
11306702 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCK2 Protein Structure

PRK

PRK: Phosphoribulokinase / Uridine kinase family (22 - 216)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

uridine-cytidine kinase 2

cytidine monophosphokinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148394 UCK2 Inhibitor-1 Inhibitor 96.33% Unkown
HY-78574 N-Benzoylcytidine ≥98.0% Unkown
HY-148395 UCK2 Inhibitor-2 Inhibitor / Unkown
HY-148396 UCK2 Inhibitor-3 / Unkown
HY-RS15404 UCK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UCK2 VGNC VGNC:78718
Felis catus UCK2 VGNC VGNC:66797
Canis familiaris UCK2 VGNC VGNC:56145
Mus musculus UCK2 MGD MGI:1931744
Rattus norvegicus UCK2 RGD RGD:620742
Bos taurus UCK2 VGNC VGNC:36635
Others UCK2 NCBI