UQCRH - ubiquinol-cytochrome c reductase hinge protein Gene

Homo sapiens

Also known as QCR6; UQCR8; MC3DN11

Gene ID: 7388 | Gene type: protein coding

About UQCRH

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,303,698-46,316,776 (from NCBI)

This gene has 5 transcripts (splice variants), 232 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 164.7), colon (RPKM 117.2) and 25 other tissues.

Summary

Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

UQCRH Products(3)

mRNA	Protein	Name
NM_001297565.2	NP_001284494.1	cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor
NM_001297566.2	NP_001284495.1	cytochrome b-c1 complex subunit 6, mitochondrial isoform 3 precursor
NM_006004.4	NP_005995.2	cytochrome b-c1 complex subunit 6, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables ubiquinol-cytochrome-c reductase activity	IMP IMP: Inferred from mutant phenotype	34750991	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UQCRH Protein Structure

UCR_hinge

0
91 a.a.

Protein Preferred Names

Protein Names

cytochrome b-c1 complex subunit 6, mitochondrial

complex III subunit 6

Recombinant UQCRH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71088	UQCRH Protein, Human (GST)	P07919 (M1-K91)	≥95%

Related Diseases

Diseases

Alias

Fibroosseous Pseudotumor Of Digits

Fibroosseous Digital Pseudotumor

Fibroosseous Pseudotumor Of The Digits

Non-Syndromic X-Linked Intellectual Disability 1

Mrx1	Mrx18
Mrx78	X-Linked Mental Retardation 1/78
X-Linked Mental Retardation 18

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15502	UQCRH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UQCRH	MGD	MGI:1913826
Rattus norvegicus	UQCRH	RGD	RGD:1305987

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