1. Gene
  2. VDAC1 - voltage dependent anion channel 1 Gene

VDAC1 - voltage dependent anion channel 1 Gene

Homo sapiens

Also known as PORIN; VDAC-1

Gene ID: 7416 | Gene type: protein coding

About VDAC1

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:133,971,871-134,114,540 (from NCBI)

This gene has 7 transcripts (splice variants), 247 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 107.1), duodenum (RPKM 94.9) and 25 other tissues.

Summary

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

VDAC1 Products(20)

mRNA Protein Name
NM_001401008.1 NP_001387937.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401009.1 NP_001387938.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401010.1 NP_001387939.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401011.1 NP_001387940.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401016.1 NP_001387945.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401017.1 NP_001387946.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401018.1 NP_001387947.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401020.1 NP_001387949.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401021.1 NP_001387950.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401022.1 NP_001387951.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401023.1 NP_001387952.1 voltage-dependent anion-selective channel protein 1 isoform 1
NM_001401024.1 NP_001387953.1 voltage-dependent anion-selective channel protein 1 isoform 2
NM_001401025.1 NP_001387954.1 voltage-dependent anion-selective channel protein 1 isoform 3
NM_001401026.1 NP_001387955.1 voltage-dependent anion-selective channel protein 1 isoform 4
NM_001401027.1 NP_001387956.1 voltage-dependent anion-selective channel protein 1 isoform 5
NM_001401028.1 NP_001387957.1 voltage-dependent anion-selective channel protein 1 isoform 6
NM_001401029.1 NP_001387958.1 voltage-dependent anion-selective channel protein 1 isoform 7
NM_001401031.1 NP_001387960.1 voltage-dependent anion-selective channel protein 1 isoform 7
NM_001401032.1 NP_001387961.1 voltage-dependent anion-selective channel protein 1 isoform 7
NM_003374.3 NP_003365.1 voltage-dependent anion-selective channel protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ceramide binding IDA
IDA: Inferred from direct assay
31015432 GOA
enables cholesterol binding IDA
IDA: Inferred from direct assay
31015432 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18832158 GOA
enables phosphatidylcholine binding IDA
IDA: Inferred from direct assay
31015432 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9843949 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21370995 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
25296756 GOA
enables voltage-gated monoatomic anion channel activity IDA
IDA: Inferred from direct assay
8420959 GOA
Biological Process GO Annotation Evidence Reference Source
involved in apoptotic process IDA
IDA: Inferred from direct assay
25296756 GOA
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
involved in mitochondrial transmembrane transport IDA
IDA: Inferred from direct assay
38065946 GOA
involved in monoatomic anion transport IDA
IDA: Inferred from direct assay
8420959 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
32047033 GOA
involved in negative regulation of calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
32047033 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
29907098 GOA
involved in positive regulation of type 2 mitophagy IMP
IMP: Inferred from mutant phenotype
32047033 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
27641616 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
31015432 GOA
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
18063578 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
7539795 GOA
part of mitochondrial permeability transition pore complex IDA
IDA: Inferred from direct assay
26387735 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
30188326 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
25296756 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VDAC1 Protein Structure

Porin_3

Porin_3: Eukaryotic porin (4 - 276)

  • 0
  • 100
  • 200
  • 283 a.a.
Protein Preferred Names Protein Names

voltage-dependent anion-selective channel protein 1

outer mitochondrial membrane protein porin 1

VDAC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VDAC1 P21796 RTL10 Homo sapiens Q7L3V2 23055042
Intra
VDAC1 P21796 RTL10 Homo sapiens Q7L3V2 23055042
Intra
VDAC1 P21796 APOE Homo sapiens P02649 33961781
Intra
VDAC1 P21796 APOE Homo sapiens P02649 28514442
Intra
VDAC1 P21796 PRDX6 Homo sapiens P30041 29128334
Intra
VDAC1 P21796 PRDX6 Homo sapiens P30041 29128334
Intra
VDAC1 P21796 VDAC2 Homo sapiens P45880 35271311
Intra
VDAC1 P21796 VDAC2 Homo sapiens P45880 29128334
Intra
VDAC1 P21796 VDAC2 Homo sapiens P45880 29128334
Intra
VDAC1 P21796 VDAC1 Homo sapiens P21796 18832158
Intra
VDAC1 P21796 VDAC1 Homo sapiens P21796 18832158
Intra
VDAC1 P21796 VDAC3 Homo sapiens Q9Y277 30021884
Intra
VDAC1 P21796 VDAC1 Homo sapiens P21796
NMR
18832158
Intra
VDAC1 P21796 VDAC1 Homo sapiens P21796
GMS
18832158
Intra
VDAC1 P21796 VDAC3 Homo sapiens Q9Y277 29128334
Intra
VDAC1 P21796 VDAC3 Homo sapiens Q9Y277 35271311
Intra
VDAC1 P21796 SLC25A6 Homo sapiens P12236 29128334
Intra
VDAC1 P21796 YWHAE Homo sapiens P62258 29128334
Intra
VDAC1 P21796 YWHAE Homo sapiens P62258 29128334
Intra
VDAC1 P21796 CDK1 Homo sapiens P06493 29128334
Intra
VDAC1 P21796 CDK1 Homo sapiens P06493 29128334
Intra
VDAC1 P21796 LRRK2 Homo sapiens Q5S007 21370995
Intra
VDAC1 P21796 HK1 Homo sapiens P19367 35271311
Intra
VDAC1 P21796 PB1 Influenza A virus P0C0U1 16201016
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Typhoid Fever

Typhoid

Enteric Fever

Typhoidal Salmonellosis

Ileotyphus

Infection By Salmonella Typhi

Typhoid Any Site

Typhoid Fever Any Site

Typhoid Infection

Typhoid Infection Any Site

Typhoid Fever Confirmed

Enteric Fever Nos

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Parathyroid Oncocytic Adenoma

Parathyroid Gland Oncocytic Adenoma

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy

3-Methylglutaconic Aciduria Type 3

Costeff Syndrome

Mga3

Costeff Optic Atrophy Syndrome

Optic Atrophy Plus Syndrome

Infantile Optic Atrophy With Chorea And Spastic Paraplegia

3-Methylglutaconic Aciduria Type Iii

Autosomal Recessive Optic Atrophy Plus Syndrome

Autosomal Recessive Optic Atrophy Type 3

Opa3 Defect

MGCA3

Mga, Type Iii

Iraqi Jewish Optic Atrophy Plus

Mga Type Iii

Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

Iraqi-Jewish 'Optic Atrophy Plus'

Optic Atrophy 3, Autosomal Recessive

Opa3, Autosomal Recessive

Opa3-Related 3-Methylglutaconic Aciduria

Iraqi-Jewish Optic Atrophy Plus

Atrophy Of Optic Disc

3-Alpha Methylglutaconic Aciduria Type Iii

Optic Atrophy 3

Optic Atrophy Infantile With Chorea And Spastic Paraplegia

Autosomal Recessive Opa3

Autosomal Recessive Optic Atrophy 3

3-Methylglutaconic Aciduria 3

3-Alpha-Methylglutaconic Aciduria Type 3

Optic Atrophy 3 Autosomal Recessive

Atrophy, Optic

Atrophy, Optic, Plus Syndrome

Optic Nerve Atrophy

Primary Optic Atrophy

Oa - [Optic Atrophy]

Second Cranial Nerve Atrophy

Second Cranium Nerve Atrophy

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Mitochondrial Myopathy

Mitochondrial Myopathies

Mitochondrial Cytopathy

Myopathies In Mitochondrial Disorders

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy

Leber Hereditary Optic Neuropathy

LHON

Leber'S Hereditary Optic Neuropathy

Leber Optic Atrophy, Susceptibility To

Leber'S Optic Atrophy

LOAM

Loas

Leber'S Disease

Leber'S Optic Neuropathy

Optic Atrophy, Hereditary, Leber

Lhon, Modifier Of

Optic Atrophy, Leber Type

Hereditary Optic Neuroretinopathy

Leber Hereditary Optic Atrophy

Loa

Optic Atrophy Leber Type

Leber Hereditary Optic Neuropathy, Modifier

Leber Hereditary Optic Neuropathy Susceptibility

Modifier Of Leber Hereditary Optic Neuropathy

Lebers Hereditary Optic Neuropathy

Leber Congenital Amaurosis

Leigh Syndrome

Leigh Disease

Infantile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

LS

Sne

Leigh'S Disease

Leigh Syndrome Due To Mitochondrial Complex I Deficiency

Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

Subacute Necrotizing Encephalomyelopathy

Necrotizing Encephalopathy Infantile Subacute Of Leigh

Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

Infantile Necrotizing Encephalomyelopathy

Juvenile Subacute Necrotizing Encephalomyelopathy

Leigh'S Necrotizing Encephalopathy

Subacute Necrotizing Encephalopathy

Juvenile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

Leigh Syndrome Due To Mitochondrial Complex V Deficiency

Encephalopathy, Subacute Necrotizing, Infantile

Encephalopathy, Subacute Necrotizing, Juvenile

Maternally Inherited Leigh Syndrome

Subacute Necrotising Encephalomyelopathy

Subacute Necrotising Encephalopathy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta VDAC1 VGNC VGNC:103885
Mus musculus VDAC1 MGD MGI:106919
Rattus norvegicus VDAC1 RGD RGD:621575
Bos taurus VDAC1 VGNC VGNC:36782
Felis catus VDAC1 VGNC VGNC:97681
Canis familiaris VDAC1 VGNC VGNC:48246