Itch - itchy, E3 ubiquitin protein ligase Gene

Mus musculus

Also known as AIP4; A130065M08; 6720481N21Rik; 8030492O04Rik; C230047C07Rik

Gene ID: 16396 | Gene type: protein coding

About Itch

Summary

Enables Ligase activity. Involved in several processes, including negative regulation of JNK cascade; negative regulation of NF-kappaB transcription factor activity; and protein K48-linked ubiquitination. Acts upstream of or within several processes, including cellular protein metabolic process; negative regulation of alpha-beta T cell proliferation; and positive regulation of T cell anergy. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human ITCH (itchy E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Itch Products(2)

mRNA	Protein	Name
NM_001243712.1	NP_001230641.1	E3 ubiquitin-protein ligase Itchy
NM_008395.3	NP_032421.2	E3 ubiquitin-protein ligase Itchy

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ligase activity	IMP IMP: Inferred from mutant phenotype	18246070	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11782481	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	14973438	MGI
acts upstream of T cell anergy	IMP IMP: Inferred from mutant phenotype	14973438	MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	14973438	MGI
involved in negative regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	18246070	MGI
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	18246070	MGI
involved in negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	19881509	MGI
acts upstream of or within positive regulation of T cell anergy	IMP IMP: Inferred from mutant phenotype	14973438	MGI
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	14973438	MGI
acts upstream of or within positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	14973438	MGI
involved in protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	18246070	MGI
acts upstream of protein catabolic process	IMP IMP: Inferred from mutant phenotype	14973438	MGI
acts upstream of or within protein polyubiquitination	IDA IDA: Inferred from direct assay	14973438	MGI
involved in regulation of protein deubiquitination	IMP IMP: Inferred from mutant phenotype	18246070	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	14973438	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	17137798	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14973438	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17137798	MGI
located in membrane	IDA IDA: Inferred from direct assay	14973438	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11555636	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Itchy

HECT-type E3 ubiquitin transferase Itchy homolog

Itch Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Itch	Q8C863	Cyld	Mus musculus	Q80TQ2	Anti Bait CoIP	22057290

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0548A	Hydroxyzine dihydrochloride	Antagonist	99.81%	Unkown
HY-B1183	Hydrocortisone acetate	Agonist	99.14%	Yes
HY-B0548	Hydroxyzine	Antagonist	99.60%	Unkown
HY-106566	Alclometasone dipropionate		≥96.0%	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99025	Lebrikizumab	Inhibitor	99.90%	Unkown
HY-P99162	Nemolizumab	Inhibitor	99.70%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-136642	Fluocinolone	Agonist	99.66%	Phase 4
HY-14939	Vapitadine		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129047	Trypsin	Activator	/	Unkown
HY-103368	Eact	Activator	98.14%	Unkown
HY-148244	MS47134		99.88%	Unkown
HY-118069	(R)-ZINC-3573	Agonist	99.81%	Unkown
HY-103320A	Calhex 231 hydrochloride	Inhibitor	99.81%	Unkown
HY-129047A	Trypsin (MS grade)	Activator	95.00%	Unkown
HY-147051	MRGPRX4 modulator-2		99.64%	Unkown
HY-145997	MRGPRX4 modulator-1		99.09%	Unkown
HY-148949	Kallikrein 5-IN-2		98.69%	Unkown
HY-B1144A	Chlormidazole hydrochloride	Inhibitor	98.98%	Unkown
HY-P1192	GR-73632	Agonist	99.93%	Unkown
HY-103320B	(1R,2R)-Calhex 231 hydrochloride	Control	99.07%	Unkown
HY-145153	S-777469	Agonist	98.83%	Unkown
HY-108425	AMG8379	Antagonist	/	Unkown
HY-108425B	(Rac)-AMG8379	Antagonist	/	Unkown
HY-103320	Calhex 231	Antagonist	/	Unkown
HY-108425A	AMG8380	Antagonist	/	Unkown
HY-124356	Alcaftadine carboxylic acid		/	Unkown
HY-135495	AM-0466	Inhibitor	/	Unkown
HY-143481	Nav1.8-IN-2	Inhibitor	/	Unkown
HY-157496	EP3 antagonist 7	Antagonist	/	Unkown
HY-163840	GFRα2/3-IN-1	Inhibitor	/	Unkown
HY-P5357	SFNGGP-NH2		/	Unkown
HY-RS06943	ITCH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124356AS	Alcaftadine carboxylic acid-d3 sodium		/	Unkown
HY-N12040	γ-Isofagarine		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itch	NCBI	NCBI:83737

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