Hdac6 - histone deacetylase 6 Gene

Mus musculus

Also known as Hd6; Sfc6; Hdac5; mHDA2

Gene ID: 15185 | Gene type: protein coding

About Hdac6

Chromosome X: 7,796,359-7,814,128 reverse strand.GRCm39:CM001013.3

This gene has 10 transcripts (splice variants), 182 orthologues, 10 paralogues and is associated with 10 phenotypes. Ubiquitous expression in genital fat pad adult (RPKM 65.5), whole brain E14.5 (RPKM 26.3) and 27 other tissues.

Summary

Enables cytoskeletal protein binding activity; protein deacetylase activity; and ubiquitin binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein deacetylation; and protein destabilization. Acts upstream of or within several processes, including aggresome assembly; cellular protein metabolic process; and neuron projection morphogenesis. Located in several cellular components, including dendrite; microtubule cytoskeleton; and perikaryon. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early embryo; future midbrain; gut gland; and lung. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Apr 2022]

Hdac6 Products(7)

mRNA	Protein	Name
NM_001411606.1	NP_001398535.1	histone deacetylase 6 isoform 2
NM_001130416.2	NP_001123888.1	histone deacetylase 6 isoform 2
NM_001411608.1	NP_001398537.1	histone deacetylase 6 isoform 3
NM_010413.4	NP_034543.3	histone deacetylase 6 isoform 2
NM_001411612.1	NP_001398541.1	histone deacetylase 6 isoform 4
NM_001411604.1	NP_001398533.1	histone deacetylase 6 isoform 1
NM_001411607.1	NP_001398536.1	histone deacetylase 6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	12606581	MGI
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	9891014	MGI
enables histone deacetylase activity	IMP IMP: Inferred from mutant phenotype	24882211	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	19893491	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11689694	MGI
enables tau protein binding	IPI IPI: Inferred from physical interaction	19457097	MGI
enables tubulin deacetylase activity	IDA IDA: Inferred from direct assay	12606581	MGI
enables tubulin deacetylase activity	IGI IGI: Inferred from genetic interaction	27430620	MGI
enables tubulin deacetylase activity	IMP IMP: Inferred from mutant phenotype	19457097	MGI
enables ubiquitin binding	IDA IDA: Inferred from direct assay	11689694	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Hsp90 deacetylation	IMP IMP: Inferred from mutant phenotype	17785525	MGI
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	28255013	MGI
acts upstream of or within aggresome assembly	IGI IGI: Inferred from genetic interaction	16810319	MGI
acts upstream of or within cellular response to misfolded protein	IMP IMP: Inferred from mutant phenotype	17785525	MGI
acts upstream of or within collateral sprouting	IMP IMP: Inferred from mutant phenotype	24113571	MGI
acts upstream of or within dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	24113571	MGI
acts upstream of or within erythrocyte enucleation	IMP IMP: Inferred from mutant phenotype	28255013	MGI
involved in mitochondrion localization	IMP IMP: Inferred from mutant phenotype	20457763	MGI
acts upstream of or within negative regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	12486003	MGI
involved in peptidyl-lysine deacetylation	IMP IMP: Inferred from mutant phenotype	23962722	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23962722	MGI
involved in positive regulation of type 2 mitophagy	IGI IGI: Inferred from genetic interaction	20457763	MGI
acts upstream of or within protein deacetylation	IDA IDA: Inferred from direct assay	12486003	MGI
acts upstream of or within protein deacylation	IMP IMP: Inferred from mutant phenotype	28255013	MGI
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	24882211	MGI
acts upstream of or within protein polyubiquitination	IDA IDA: Inferred from direct assay	11689694	MGI
acts upstream of or within protein-containing complex disassembly	IGI IGI: Inferred from genetic interaction	17785525	MGI
acts upstream of or within regulation of establishment of protein localization	IMP IMP: Inferred from mutant phenotype	22792322	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23126280	MGI
involved in tubulin deacetylation	IDA IDA: Inferred from direct assay	19893491	MGI
acts upstream of or within tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	12606581	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	16810319	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	16810319	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	17785525	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16933150	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11689694	MGI
located in cytosol	IDA IDA: Inferred from direct assay	19893491	MGI
located in dendrite	IDA IDA: Inferred from direct assay	16933150	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	12606581	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	24113571	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	24113571	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19893491	MGI
located in perikaryon	IDA IDA: Inferred from direct assay	16933150	MGI
part of protein-containing complex	IPI IPI: Inferred from physical interaction	17785525	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac6 Protein Structure

Arginase_HDAC

HDAC6-dom2

zf-UBP

0
200
400
600
800
1000
1149 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 6

histone deacetylase 5	histone deacetylase mHDA2
scurfy candidate 6	tubulin-lysine deacetylase HDAC6

Hdac6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Hdac6	Q9Z2V5	Cyld	Mus musculus	Q80TQ2	Anti Bait CoIP	19893491
Intra	Hdac6	Q9Z2V5	Cyld	Mus musculus	Q80TQ2	Fluorescence	19893491
Cross	Hdac6	Q9Z2V5	GRK2	Bos taurus	P21146	Anti Tag CoIP	22193721
Cross	Hdac6	Q9Z2V5	ubiq_chick	Gallus gallus	P62973	Pull Down	25342804
Cross	Hdac6	Q9Z2V5	Ccdc141	Rattus norvegicus	D3ZEY0	Anti Tag CoIP	27737934
Cross	Hdac6	Q9Z2V5	Ccdc141	Rattus norvegicus	D3ZEY0	Y2H	27737934

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-10225	Belinostat	Inhibitor	99.95%	Yes
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes
HY-B0494	Bufexamac	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14718A	Resminostat hydrochloride	Inhibitor	99.68%	Phase 4
HY-10990	Abexinostat	Inhibitor	99.00%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Phase 2
HY-138799	KA2507	Inhibitor	99.24%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.64%	Phase 2
HY-14718	Resminostat	Inhibitor	99.84%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.30%	Phase 1
HY-124295	MPT0E028	Inhibitor	99.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (188)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13271A	Tubastatin A	Inhibitor	98.37%	Unkown
HY-18361	TMP195	Inhibitor	99.57%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-N0931	Santacruzamate A	Inhibitor	99.04%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-15224	PCI-34051	Inhibitor	99.84%	Unkown
HY-13271	Tubastatin A Hydrochloride	Inhibitor	98.19%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-18613	CAY10603	Inhibitor	≥98.0%	Unkown
HY-19327	ACY-738	Inhibitor	99.92%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-111818	TH34	Inhibitor	99.52%	Unkown
HY-111791	ACY-1083	Inhibitor	99.80%	Unkown
HY-153392	TYA-018	Inhibitor	98.71%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-N0071	Crotonoside	Inhibitor	99.64%	Unkown
HY-19328	ACY-775	Inhibitor	99.69%	Unkown
HY-111400	SR-4370	Inhibitor	99.95%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.94%	Unkown
HY-144779	HDAC10-IN-1	Inhibitor	99.11%	Unkown
HY-100871	WT-161	Inhibitor	98.36%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-126147	J22352	Inhibitor	99.04%	Unkown
HY-18712	BG45	Inhibitor	99.96%	Unkown
HY-19747	HPOB	Inhibitor	99.80%	Unkown
HY-116818	Crebinostat	Inhibitor	99.79%	Unkown
HY-161307	T-518	Inhibitor	98.40%	Unkown
HY-161305	SE-7552	Inhibitor	99.48%	Unkown
HY-13267	Droxinostat	Inhibitor	98.91%	Unkown
HY-114414	HDACs/mTOR Inhibitor 1	Inhibitor	99.01%	Unkown
HY-126330	SS-208	Inhibitor	99.00%	Unkown
HY-130538	1-Naphthohydroxamic acid	Inhibitor	99.72%	Unkown
HY-123976	MPT0G211	Inhibitor	99.79%	Unkown
HY-12954	PTACH	Inhibitor	99.65%	Unkown
HY-164099	LSD1/HDAC6-IN-2	Inhibitor	99.66%	Unkown
HY-110280	MC1742	Inhibitor	99.20%	Unkown
HY-124053	BRD2492	Inhibitor	99.18%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-18700	BRD73954	Inhibitor	≥98.0%	Unkown
HY-135890	CG347B	Inhibitor	98.93%	Unkown
HY-114483	AES-135	Inhibitor	98.21%	Unkown
HY-138831	AES-350	Inhibitor	99.30%	Unkown
HY-158075	DNMT/HDAC-IN-1	Inhibitor	99.87%	Unkown
HY-152134	HDAC6 degrader-3	Degrader	98.60%	Unkown
HY-124782	HDAC8-IN-8	Inhibitor	99.01%	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-162616	SelSA	Inhibitor	99.83%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-120448A	QTX125 TFA	Inhibitor	99.93%	Unkown
HY-120448	QTX125	Inhibitor	/	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-151261	HDAC6-IN-13	Inhibitor	98.08%	Unkown
HY-171139	PROTAC HDAC6 degrader 2	Inhibitor	/	Unkown
HY-131970	LSD1/HDAC6-IN-1	Inhibitor	/	Unkown
HY-151464	SHP2/HDAC-IN-1	Inhibitor	/	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-128582	PI3K/HDAC-IN-1	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Unkown
HY-123976A	MPT0G211 mesylate	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-158371	HDAC/CK2-IN-1	Inhibitor	/	Unkown
HY-151364	HDAC6/8/BRPF1-IN-1	Inhibitor	/	Unkown
HY-147991	PDE5/HDAC-IN-1	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-147892	HDAC-IN-42	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-157481	HDAC1-IN-6	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-162330	HDAC6-IN-36	Inhibitor	/	Unkown
HY-163503	HDAC6-IN-38	Inhibitor	/	Unkown
HY-157385	HDAC-IN-67	Inhibitor	/	Unkown
HY-169156	HDAC6-IN-49	Inhibitor	/	Unkown
HY-152235	HDAC6-IN-15	Inhibitor	/	Unkown
HY-162658	Leuxinostat	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-161667	GSK-3β/HDAC-IN-1	Inhibitor	/	Unkown
HY-150597	HDAC-IN-46	Inhibitor	/	Unkown
HY-161304	HDAC6-IN-33	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-144725	HDAC1/6-IN-1	Inhibitor	/	Unkown
HY-168508	PB200	Inhibitor	/	Unkown
HY-157314	HDAC6-IN-27	Inhibitor	/	Unkown
HY-144098	HDAC8-IN-2	Inhibitor	/	Unkown
HY-161783	HDAC6-IN-45	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-170379	HDAC-IN-84	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-151263	G4/HDAC-IN-1	Inhibitor	/	Unkown
HY-162378	LT-630	Inhibitor	/	Unkown
HY-168477	HDAC1-IN-8	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-158308	HDAC6-IN-41	Inhibitor	/	Unkown
HY-169940	Fibrostat	Inhibitor	/	Unkown
HY-161984	HDAC-IN-76	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-150503	KH-259	Inhibitor	/	Unkown
HY-144332	PHD2/HDACs-IN-1	Inhibitor	/	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	/	Unkown
HY-163368	HDAC6-IN-34	Inhibitor	/	Unkown
HY-170495	HDAC6 degrader-5	Inhibitor	/	Unkown
HY-159171	sEH/HDAC6-IN-2	Inhibitor	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-163894	HDAC6-IN-48	Inhibitor	/	Unkown
HY-163369	HDAC6-IN-35	Inhibitor	/	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-169226	HDAC6-IN-51	Inhibitor	/	Unkown
HY-162678	HDAC-IN-75	Inhibitor	/	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-163834	HDAC6-IN-47	Inhibitor	/	Unkown
HY-143241	HDAC-IN-34	Inhibitor	/	Unkown
HY-162910	HDAC-IN-79	Inhibitor	/	Unkown
HY-123971	HDAC6 degrader-4	Degrader	/	Unkown
HY-150586	PTG-0861	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-147731	HDAC6-IN-9	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-149578	Tubulin/HDAC-IN-3	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-146539	HDAC-IN-35	Inhibitor	/	Unkown
HY-162781	HDAC1/6-IN-2	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-115941	HDAC-IN-9	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-162319	Tubulin/HDAC-IN-4	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-169400	HDACs/EZH2-IN-1	Inhibitor	/	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.14%	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-149372	HDAC6-IN-17	Inhibitor	/	Unkown
HY-161350	ALK/HDAC-IN-1	Inhibitor	/	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-163207	sEH/HDAC6-IN-1	Inhibitor	/	Unkown
HY-126566	Trichostatin C	Inhibitor	/	Unkown
HY-161155	HDAC6-IN-31	Inhibitor	/	Unkown
HY-146750	HDAC-IN-37	Inhibitor	/	Unkown
HY-130493	HPB	Inhibitor	/	Unkown
HY-159172	HDAC3-IN-4	Inhibitor	/	Unkown
HY-169938	LSD1/HDAC-IN-2	Inhibitor	/	Unkown
HY-146293	HDAC6/HSP90-IN-1	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-163359	CYP17A1/HDAC6-IN-1	Inhibitor	/	Unkown
HY-161524	HDAC6-IN-43	Inhibitor	/	Unkown
HY-172129	HDAC6-IN-52	Inhibitor	/	Unkown
HY-169405	AAK1/HDACs-IN-1	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-162955	LSD1/HDAC-IN-1	Inhibitor	/	Unkown
HY-161306	ITF5924	Inhibitor	/	Unkown
HY-161854	LASSBio-1911	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-144449	mTOR/HDAC6-IN-1	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-161516	HDAC6-IN-42	Inhibitor	/	Unkown
HY-150772	Tubulin/HDAC-IN-1	Inhibitor	/	Unkown
HY-139181	NR160	Inhibitor	/	Unkown
HY-152133	PROTAC HDAC6 degrader 1	Degrader	/	Unkown
HY-151153	HDAC1-IN-5	Inhibitor	/	Unkown
HY-169157	HDAC6-IN-50	Inhibitor	/	Unkown
HY-133147	HDAC3/6-IN-2	Inhibitor	/	Unkown
HY-150774	HDAC6/HSP90-IN-2	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-161688	HDAC-IN-73	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-144782	HDAC10-IN-2	Inhibitor	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown
HY-159109	HDAC6-IN-46	Inhibitor	/	Unkown
HY-150694	HDAC6-IN-11	Inhibitor	/	Unkown
HY-141701	mTOR/HDAC-IN-1	Inhibitor	/	Unkown
HY-149946	HDAC-IN-57	Inhibitor	/	Unkown
HY-139815	ZYJ-34c	Inhibitor	/	Unkown
HY-139795	ZYJ-25e	Inhibitor	/	Unkown
HY-160845	HDAC6-IN-39	Inhibitor	/	Unkown
HY-19754	CRA-026440	Inhibitor	/	Unkown
HY-160846	HDAC6-IN-40	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown
HY-119316A	CM-545	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hdac6	NCBI	NCBI:10013

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