2. Gene
  3. Hdac6 - histone deacetylase 6 Gene

Hdac6 - histone deacetylase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hd6; Sfc6; Hdac5; mHDA2

Gene ID: 15185 | Gene type: protein coding

About Hdac6

Chromosome X: 7,796,359-7,814,128 reverse strand.GRCm39:CM001013.3

This gene has 10 transcripts (splice variants), 182 orthologues, 10 paralogues and is associated with 10 phenotypes. Ubiquitous expression in genital fat pad adult (RPKM 65.5), whole brain E14.5 (RPKM 26.3) and 27 other tissues.

Summary

Enables cytoskeletal protein binding activity; protein deacetylase activity; and ubiquitin binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein deacetylation; and protein destabilization. Acts upstream of or within several processes, including aggresome assembly; cellular protein metabolic process; and neuron projection morphogenesis. Located in several cellular components, including dendrite; microtubule cytoskeleton; and perikaryon. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early embryo; future midbrain; gut gland; and lung. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Apr 2022]

Hdac6 Products(7)

mRNA Protein Name
NM_001411606.1 NP_001398535.1 histone deacetylase 6 isoform 2
NM_001130416.2 NP_001123888.1 histone deacetylase 6 isoform 2
NM_001411608.1 NP_001398537.1 histone deacetylase 6 isoform 3
NM_010413.4 NP_034543.3 histone deacetylase 6 isoform 2
NM_001411612.1 NP_001398541.1 histone deacetylase 6 isoform 4
NM_001411604.1 NP_001398533.1 histone deacetylase 6 isoform 1
NM_001411607.1 NP_001398536.1 histone deacetylase 6 isoform 2

Hdac6 Protein Structure

Arginase_HDAC

Arginase_HDAC: cl17011 (97 - 433)

HDAC6-dom2

HDAC6-dom2: cd10003 (483 - 833)

zf-UBP

zf-UBP: pfam02148 (1066 - 1128)

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  • 1149 a.a.
Protein Preferred Names Protein Names

histone deacetylase 6

histone deacetylase 5

histone deacetylase mHDA2

scurfy candidate 6

tubulin-lysine deacetylase HDAC6

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-10225 Belinostat Inhibitor 99.95% Yes
HY-13322 Pracinostat Inhibitor 99.82% Yes
HY-B0494 Bufexamac Inhibitor ≥98.0% Unkown
Clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-138799 KA2507 Inhibitor 99.24% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-14718 Resminostat Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
Pre-clinical Phase
Bioactive Molecules (173)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13271A Tubastatin A Inhibitor 98.37% Unkown
HY-18361 TMP195 Inhibitor 99.57% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-13428 Tubacin Inhibitor 99.54% Unkown
HY-N0931 Santacruzamate A Inhibitor 99.04% Unkown
HY-15224 PCI-34051 Inhibitor 99.75% Unkown
HY-18360 TMP269 Inhibitor 98.05% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 98.19% Unkown
HY-18613 CAY10603 Inhibitor ≥98.0% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-16699 Nexturastat A Inhibitor 98.28% Unkown
HY-111818 TH34 Inhibitor 99.52% Unkown
HY-111791 ACY-1083 Inhibitor 99.80% Unkown
HY-153392 TYA-018 Inhibitor 98.71% Unkown
HY-115475 SW-100 Inhibitor 99.59% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-N0071 Crotonoside Inhibitor 99.64% Unkown
HY-111400 SR-4370 Inhibitor 99.95% Unkown
HY-19328 ACY-775 Inhibitor 99.69% Unkown
HY-18976 UF010 99.84% Unkown
HY-144779 HDAC10-IN-1 Inhibitor 99.11% Unkown
HY-126147 J22352 Inhibitor 99.04% Unkown
HY-100871 WT-161 Inhibitor 98.36% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-18712 BG45 Inhibitor 99.96% Unkown
HY-116818 Crebinostat Inhibitor 99.79% Unkown
HY-13267 Droxinostat Inhibitor 98.91% Unkown
HY-19747 HPOB Inhibitor 99.80% Unkown
HY-161305 SE-7552 Inhibitor 99.48% Unkown
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 99.01% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.72% Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-18700 BRD73954 Inhibitor ≥98.0% Unkown
HY-123976 MPT0G211 Inhibitor 99.79% Unkown
HY-110280 MC1742 Inhibitor 99.20% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-161307 T-518 Inhibitor 98.40% Unkown
HY-135890 CG347B Inhibitor 98.93% Unkown
HY-114483 AES-135 Inhibitor 98.21% Unkown
HY-124053 BRD2492 Inhibitor 99.18% Unkown
HY-152134 HDAC6 degrader-3 Degrader 98.60% Unkown
HY-164099 LSD1/HDAC6-IN-2 Inhibitor 99.66% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-138831 AES-350 Inhibitor 99.30% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-120448 QTX125 Inhibitor / Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-120448A QTX125 TFA Inhibitor 99.93% Unkown
HY-124782 HDAC8-IN-8 Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-131970 LSD1/HDAC6-IN-1 Inhibitor / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-123976A MPT0G211 mesylate Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-139181 NR160 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-144782 HDAC10-IN-2 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-143241 HDAC-IN-34 Inhibitor / Unkown
HY-169156 HDAC6-IN-49 Inhibitor / Unkown
HY-149721 HDAC4-IN-1 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-144725 HDAC1/6-IN-1 Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-150694 HDAC6-IN-11 Inhibitor / Unkown
HY-161984 HDAC-IN-76 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-162378 LT-630 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-152235 HDAC6-IN-15 Inhibitor / Unkown
HY-163368 HDAC6-IN-34 Inhibitor / Unkown
HY-168508 PB200 Inhibitor / Unkown
HY-158075 DNMT/HDAC-IN-1 Inhibitor / Unkown
HY-161667 GSK-3β/HDAC-IN-1 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-163894 HDAC6-IN-48 Inhibitor / Unkown
HY-157314 HDAC6-IN-27 Inhibitor / Unkown
HY-163503 HDAC6-IN-38 Inhibitor / Unkown
HY-159109 HDAC6-IN-46 Inhibitor / Unkown
HY-161155 HDAC6-IN-31 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-144332 PHD2/HDACs-IN-1 Inhibitor / Unkown
HY-162330 HDAC6-IN-36 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-151153 HDAC1-IN-5 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-150597 HDAC-IN-46 Inhibitor / Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-157385 HDAC-IN-67 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-163369 HDAC6-IN-35 Inhibitor / Unkown
HY-150586 PTG-0861 Inhibitor / Unkown
HY-161304 HDAC6-IN-33 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-158371 HDAC/CK2-IN-1 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-152133 PROTAC HDAC6 degrader 1 Degrader / Unkown
HY-162781 HDAC1/6-IN-2 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-144449 mTOR/HDAC6-IN-1 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-130493 HPB Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-161516 HDAC6-IN-42 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-126566 Trichostatin C Inhibitor / Unkown
HY-161306 ITF5924 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-147892 HDAC-IN-42 Inhibitor / Unkown
HY-123971 HDAC6 degrader-4 Degrader / Unkown
HY-158308 HDAC6-IN-41 Inhibitor / Unkown
HY-169157 HDAC6-IN-50 Inhibitor / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-163359 CYP17A1/HDAC6-IN-1 Inhibitor / Unkown
HY-162678 HDAC-IN-75 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-161688 HDAC-IN-73 Inhibitor / Unkown
HY-161854 LASSBio-1911 Inhibitor / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-139815 ZYJ-34c Inhibitor / Unkown
HY-139795 ZYJ-25e Inhibitor / Unkown
HY-160845 HDAC6-IN-39 Inhibitor / Unkown
HY-160846 HDAC6-IN-40 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac6 NCBI NCBI:10013