2. Gene
  3. VIL1 - villin 1 Gene

VIL1 - villin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VIL; D2S1471

Gene ID: 7429 | Gene type: protein coding

About VIL1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,419,123-218,453,295 (from NCBI)

This gene has 5 transcripts (splice variants), 166 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 141.0), duodenum (RPKM 126.6) and 3 other tissues.

Summary

This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border Cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]

VIL1 Products(1)

mRNA Protein Name
NM_007127.3 NP_009058.2 villin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin filament binding IDA
IDA: Inferred from direct assay
11500485 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
11500485 GOA
enables calcium ion binding IMP
IMP: Inferred from mutant phenotype
15272027 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17606613 GOA
enables lysophosphatidic acid binding IDA
IDA: Inferred from direct assay
19808673 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
14594952 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16921170 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
17606613 GOA
Biological Process GO Annotation Evidence Reference Source
involved in actin filament capping IDA
IDA: Inferred from direct assay
16921170 GOA
involved in actin filament depolymerization IDA
IDA: Inferred from direct assay
11500485 GOA
involved in actin filament polymerization IDA
IDA: Inferred from direct assay
11500485 GOA
involved in actin filament severing IDA
IDA: Inferred from direct assay
16921170 GOA
involved in barbed-end actin filament capping IMP
IMP: Inferred from mutant phenotype
15272027 GOA
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
17229814 GOA
involved in cytoplasmic actin-based contraction involved in cell motility IDA
IDA: Inferred from direct assay
15342783 GOA
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
17229814 GOA
involved in epithelial cell differentiation IEP
IEP: Inferred from expression pattern
21492153 GOA
involved in positive regulation of actin filament bundle assembly IDA
IDA: Inferred from direct assay
19808673 GOA
involved in positive regulation of actin filament depolymerization IMP
IMP: Inferred from mutant phenotype
15272027 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
16921170 GOA
involved in positive regulation of epithelial cell migration IDA
IDA: Inferred from direct assay
17229814 GOA
involved in positive regulation of epithelial cell migration IGI
IGI: Inferred from genetic interaction
18054784 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
18054784 GOA
involved in positive regulation of lamellipodium morphogenesis IGI
IGI: Inferred from genetic interaction
18054784 GOA
involved in positive regulation of lamellipodium morphogenesis IMP
IMP: Inferred from mutant phenotype
18054784 GOA
involved in regulation of actin nucleation IDA
IDA: Inferred from direct assay
16921170 GOA
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
16921170 GOA
involved in response to bacterium IDA
IDA: Inferred from direct assay
17182858 GOA
Cellular Component GO Annotation Evidence Reference Source
located in actin filament bundle IDA
IDA: Inferred from direct assay
17182858 GOA
located in filopodium IDA
IDA: Inferred from direct assay
15342783 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
16921170 GOA
located in microvillus IDA
IDA: Inferred from direct assay
17182858 GOA
located in ruffle IDA
IDA: Inferred from direct assay
15342783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VIL1 Protein Structure

Gelsolin

Gelsolin: Gelsolin repeat (28 - 107)

Gelsolin

Gelsolin: Gelsolin repeat (148 - 218)

Gelsolin

Gelsolin: Gelsolin repeat (269 - 342)

Gelsolin

Gelsolin: Gelsolin repeat (409 - 489)

Gelsolin

Gelsolin: Gelsolin repeat (529 - 595)

Gelsolin

Gelsolin: Gelsolin repeat (634 - 707)

VHP

VHP: Villin headpiece domain (792 - 827)

  • 0
  • 200
  • 400
  • 600
  • 827 a.a.
Protein Preferred Names Protein Names

villin-1

VIL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VIL1 P09327 PLCG1 Homo sapiens P19174
Anti Bait CoIP
17229814
Intra
VIL1 P09327 VIL1 Homo sapiens P09327
Density Sedimentation
17606613
Intra
VIL1 P09327 VIL1 Homo sapiens P09327
Crosslink
17606613
Intra
VIL1 P09327 VIL1 Homo sapiens P09327
GMS
17606613
Intra
VIL1 P09327 TEX11 Homo sapiens Q8IYF3
Y2H Pooling
16189514
Intra
VIL1 P09327 VIL1 Homo sapiens P09327
Pull Down
17606613
Intra
VIL1 P09327 VIL1 Homo sapiens P09327
FRET
17606613
Intra
VIL1 P09327 PLCG1 Homo sapiens P19174
FRET
17229814
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Contagious Pustular Dermatitis

Ecthyma, Contagious

Orf

Ecthyma Contagiosum

Scabby Mouth

Sheep Pox

Thistle Disease

Contagious Pustular Dermatosis
Milker'S Nodule

Poxviridae Infections

Milker Nodule

Milkers' Node

Paravaccinia

Pseudocowpox

Milker'S Nodes
Liver Disease

Liver Failure

Liver Diseases

Abnormality Of The Liver

Liver Dysfunction

Disorder Of Liver

Hepatic Disorder

Hepatic Disease

Disease Of Bilirubin Metabolism

Disorder Of Bilirubin Metabolism

Liver Decompensation

Liver Function Failure

Hepatic Failure Nos

Liver Failure Nos

End Stage Liver Disease

Decompensated Liver Failure

Decompensation Of Liver Function

Hepatic Decompensation

Hepatic Insufficiency

Liver Cell Necrosis With Hepatic Failure

Liver Insufficiency

Decompensated Liver Disease

End Stage Liver Failure

Liver Necrosis With Hepatic Failure
Spondyloepiphyseal Dysplasia, Nishimura Type

SEDN

Spondyloepiphyseal Dysplasia Nishimura Type
Meckel Diverticulum

Meckel'S Diverticulum

Persistent Vitelline Duct
Chemical Colitis
Colonic Benign Neoplasm

Colon Neoplasm

Colonic Mass

Colonic Tumor

Neoplasm Of Colon

Neoplasm Of The Colon

Colonic Neoplasms

Colon Cancer

Colon Carcinoma Nos

Colonic Cancer

Metastatic Colon Cancer Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15650 VIL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VIL1 MGD MGI:98930
Rattus norvegicus VIL1 RGD RGD:1307048
Canis familiaris VIL1 VGNC VGNC:48261
Macaca mulatta VIL1 VGNC VGNC:78768
Felis catus VIL1 VGNC VGNC:66942
Bos taurus VIL1 VGNC VGNC:36794