VRK2 - VRK serine/threonine kinase 2 Gene

Homo sapiens

Gene ID: 7444 | Gene type: protein coding

About VRK2

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:57,907,592-58,159,920 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 12 paralogues. Ubiquitous expression in adrenal (RPKM 6.3), appendix (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate Apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

VRK2 Products(9)

mRNA	Protein	Name
NM_001130480.2	NP_001123952.1	serine/threonine-protein kinase VRK2 isoform 1
NM_001130481.2	NP_001123953.1	serine/threonine-protein kinase VRK2 isoform 1
NM_001130482.2	NP_001123954.1	serine/threonine-protein kinase VRK2 isoform 2
NM_001130483.2	NP_001123955.1	serine/threonine-protein kinase VRK2 isoform 3
NM_001288836.1	NP_001275765.1	serine/threonine-protein kinase VRK2 isoform 4
NM_001288837.2	NP_001275766.1	serine/threonine-protein kinase VRK2 isoform 1
NM_001288838.2	NP_001275767.1	serine/threonine-protein kinase VRK2 isoform 3
NM_001288839.2	NP_001275768.1	serine/threonine-protein kinase VRK2 isoform 4
NM_006296.7	NP_006287.2	serine/threonine-protein kinase VRK2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16963744	GOA
enables protein domain specific binding	IDA IDA: Inferred from direct assay	22572157	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	22572157	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14645249	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	17709393	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	14645249	GOA
involved in regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	20679487	GOA
involved in regulation of interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18286207	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16704422	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22572157	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	18286207	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	18286207	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16704422	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22572157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VRK2 Protein Structure

Pkinase

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase VRK2

vaccinia related kinase 2

VRK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VRK2	Q86Y07	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	VRK2	Q86Y07	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	VRK2	Q86Y07	TMEM88	Homo sapiens	Q6PEY1	Y2H Prey Pooling	32296183
Intra	VRK2	Q86Y07	TMEM88	Homo sapiens	Q6PEY1	Y2H Array	32296183
Intra	VRK2	Q86Y07	TBXA2R	Homo sapiens	Q0VAB0	Y2H Array	32296183
Intra	VRK2	Q86Y07	TBXA2R	Homo sapiens	Q0VAB0	Y2H Prey Pooling	32296183
Intra	VRK2	Q86Y07	KSR1	Homo sapiens	Q8IVT5	Pull Down	20679487
Intra	VRK2	Q86Y07	KSR1	Homo sapiens	Q8IVT5	Anti Tag CoIP	20679487
Intra	VRK2	Q86Y07	KSR1	Homo sapiens	Q8IVT5	Confocal	20679487
Intra	VRK2	Q86Y07	KSR1	Homo sapiens	Q8IVT5	Confocal	22752157
Intra	VRK2	Q86Y07	MAP2K1	Homo sapiens	Q02750	Pull Down	20679487
Intra	VRK2	Q86Y07	MAP2K1	Homo sapiens	Q02750	CoIP	20679487
Intra	VRK2	Q86Y07	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	VRK2	Q86Y07	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	VRK2	Q86Y07	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	VRK2	Q86Y07	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	VRK2	Q86Y07	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	VRK2	Q86Y07	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	VRK2	Q86Y07	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	VRK2	Q86Y07	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	VRK2	Q86Y07	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	VRK2	Q86Y07	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Cross	VRK2	Q86Y07	ear_ebvb9	Epstein-Barr virus	P03182	Confocal	16963744
Cross	VRK2	Q86Y07	ear_ebvb9	Epstein-Barr virus	P03182	Pull Down	16963744

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Vaccinia

Pontocerebellar Hypoplasia, Type 8

Pontocerebellar Hypoplasia Type 8	PCH8
Pontocerebellar Hypoplasia Due To Chmp1a Mutation	Pontocerebellar Hypoplasia 8
Hypoplasia, Pontocerebellar, Type 8

Pontocerebellar Hypoplasia, Type 1a

Pontocerebellar Hypoplasia Type 1a	PCH1A
Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy	Pontocerebellar Hypoplasia With Anterior Horn Cell Disease
Pch1	Pontocerebellar Hypoplasia 1a
Hypoplasia, Pontocerebellar, Type 1a	Pontocerebellar Hypoplasia Type 1

Developmental And Epileptic Encephalopathy 94

Epileptic Encephalopathy, Childhood-Onset	Eeoc
DEE94	Childhood Onset Epileptic Encephalopathy
Encephalopathy, Epileptic, Childhood-Onset

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Chromosome 2p16.1-P15 Deletion Syndrome

2p15p16.1 Microdeletion Syndrome	2p15-P16.1 Microdeletion Syndrome
Del(2)(P15p16.1)	Monosomy 2p15p16.1
Monosomy 2p15-P16.1

Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1	PCH1E
Norman Disease	Pch1
Pontocerebellar Hypoplasia With Anterior Horn Cell Disease	Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy
Pontocerebellar Hypoplasia Type 1e	Pontocerebellar Hypoplasia 1e
Doid:0112322	Doid:0112330

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Adnfle	Autosomal Dominant Sleep-Related Hypermotor Epilepsy
Enfl	Benign Familial Infantile Seizures 6
Benign Familial Infantile Seizures, 6	Nocturnal Frontal Lobe Epilepsy-4
Enfl1	Epilepsy, Nocturnal Frontal Lobe, 1
Epilepsy, Nocturnal Frontal Lobe, Type 1

Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy	Janz Syndrome
Jme	Myoclonic Epilepsy, Juvenile, Susceptibility To, 1
EJM	Myoclonic Epilepsy, Juvenile
Petit Mal, Impulsive	Myoclonic Epilepsy, Juvenile 1
Myoclonic Epilepsy, Juvenile, 1	Adolescent Myoclonic Epilepsy
Juvenile Myoclonus Epilepsy	Juvenile Myoclonic Epilepsy 1
EJM1	Petit Mal Impulsive
Susceptibility To Juvenile Myoclonic Epilepsy 1	Myoclonic Epilepsy Juvenile
Epilepsy, Myoclonic, Juvenile	Myoclonic Epilepsy Of Janz
Jme - [Juvenile Myoclonic Epilepsy]

Nanophthalmos

Nanophthalmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N8692	Dihydrobaicalein	Inhibitor	99.94%	Unkown
HY-RS15703	VRK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VRK2	MGD	MGI:1917172
Rattus norvegicus	VRK2	RGD	RGD:1311585
Macaca mulatta	VRK2	VGNC	VGNC:81604
Felis catus	VRK2	VGNC	VGNC:83479
Canis familiaris	VRK2	VGNC	VGNC:48303
Bos taurus	VRK2	VGNC	VGNC:36835

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