ZFP36 - ZFP36 ring finger protein Gene

Homo sapiens

Also known as TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A

Gene ID: 7538 | Gene type: protein coding

About ZFP36

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,406,847-39,409,407 (from NCBI)

This gene has 5 transcripts (splice variants), 193 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 274.6), bone marrow (RPKM 248.5) and 25 other tissues.

Summary

Enables several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Colocalizes with RISC-loading complex. [provided by Alliance of Genome Resources, Apr 2022]

ZFP36 Products(1)

mRNA	Protein	Name
NM_003407.5	NP_003398.3	mRNA decay activator protein ZFP36

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	15014438	GOA
enables C-C chemokine binding	IPI IPI: Inferred from physical interaction	21784977	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	25038453	GOA
enables heat shock protein binding	IDA IDA: Inferred from direct assay	20221403	GOA
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	9703499	GOA
enables mRNA 3'-UTR AU-rich region binding	IMP IMP: Inferred from mutant phenotype	21784977	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	11782475	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14679154	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15014438	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16364915	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	9703499	GOA
involved in 3'-UTR-mediated mRNA destabilization	IMP IMP: Inferred from mutant phenotype	14679154	GOA
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	15014438	GOA
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	15187101	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	14766228	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	14679154	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	20166898	GOA
acts upstream of or within mRNA catabolic process	IDA IDA: Inferred from direct assay	10751406	GOA
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	10330172	GOA
involved in mRNA transport	IMP IMP: Inferred from mutant phenotype	17369404	GOA
involved in negative regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	20702587	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21784977	GOA
involved in negative regulation of viral transcription	IMP IMP: Inferred from mutant phenotype	14679154	GOA
involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	23644599	GOA
involved in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	IDA IDA: Inferred from direct assay	11279239	GOA
involved in nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	23644599	GOA
involved in positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	IDA IDA: Inferred from direct assay	16364915	GOA
involved in positive regulation of intracellular mRNA localization	IMP IMP: Inferred from mutant phenotype	17369404	GOA
involved in positive regulation of miRNA-mediated gene silencing	IMP IMP: Inferred from mutant phenotype	15766526	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	12748283	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	10330172	GOA
involved in regulation of keratinocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	27182009	GOA
involved in regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	27182009	GOA
involved in regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	27182009	GOA
involved in regulation of mRNA stability	IDA IDA: Inferred from direct assay	9703499	GOA
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	15187101	GOA
involved in regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	15014438	GOA
involved in response to starvation	IDA IDA: Inferred from direct assay	15014438	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	27182009	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	17369404	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10330172	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	15014438	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10751406	GOA
NOT part of exosome (RNase complex)	IDA IDA: Inferred from direct assay	11719186	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10330172	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	10330172	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFP36 Protein Structure

zf-CCCH

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

mRNA decay activator protein ZFP36

G0/G1 switch regulatory protein 24

ZFP36 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFP36	P26651	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	ZFP36	P26651	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	ZFP36	P26651	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	ZFP36	P26651	RUNX1T1	Homo sapiens	Q06455-2	Validated Y2H	32296183
Intra	ZFP36	P26651	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	ZFP36	P26651	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	ZFP36	P26651	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	ZFP36	P26651	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	16364915
Intra	ZFP36	P26651	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	ZFP36	P26651	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	ZFP36	P26651	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	ZFP36	P26651	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	16364915

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cervical Non-Keratinizing Squamous Cell Carcinoma

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16042	ZFP36L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16040	ZFP36 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16041	ZFP36L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZFP36	VGNC	VGNC:48612
Rattus norvegicus	ZFP36	RGD	RGD:620722
Bos taurus	ZFP36	VGNC	VGNC:37162
Mus musculus	ZFP36	MGD	MGI:99180

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