DCP1A - decapping mRNA 1A Gene

Homo sapiens

Also known as SMIF; SMAD4IP1; HSA275986; Nbla00360

Gene ID: 55802 | Gene type: protein coding

About DCP1A

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,283,429-53,347,543 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 10.4), ovary (RPKM 7.6) and 25 other tissues.

Summary

Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping Enzyme. This protein and another decapping Enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

DCP1A Products(5)

mRNA	Protein	Name
NM_001290204.2	NP_001277133.1	mRNA-decapping enzyme 1A isoform b
NM_001290205.2	NP_001277134.1	mRNA-decapping enzyme 1A isoform c
NM_001290206.2	NP_001277135.1	mRNA-decapping enzyme 1A isoform d
NM_001290207.2	NP_001277136.1	mRNA-decapping enzyme 1A isoform e
NM_018403.7	NP_060873.4	mRNA-decapping enzyme 1A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16364915	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12417715	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA methylguanosine-cap decapping	IMP IMP: Inferred from mutant phenotype	12417715	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: Inferred from mutant phenotype	24965446	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24965446	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCP1A Protein Structure

DCP1

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

mRNA-decapping enzyme 1A

DCP1 decapping enzyme homolog A

DCP1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	IF	16364915
Intra	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Bait CoIP	16364915
Intra	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	16364915
Intra	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	19966221
Intra	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	26496610
Intra	DCP1A	Q9NPI6	EDC4	Homo sapiens	Q6P2E9	Anti Tag CoIP	25036637
Intra	DCP1A	Q9NPI6	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	26496610
Intra	DCP1A	Q9NPI6	NBDY	Homo sapiens	A0A0U1RRE5	Anti Tag CoIP	27918561
Intra	DCP1A	Q9NPI6	RITA1	Homo sapiens	Q96K30	Y2H Array	25416956
Intra	DCP1A	Q9NPI6	RITA1	Homo sapiens	Q96K30	Y2H Prey Pooling	25416956
Intra	DCP1A	Q9NPI6	NSMAF	Homo sapiens	Q92636	Y2H	26133670
Intra	DCP1A	Q9NPI6	NSMAF	Homo sapiens	Q92636	Pull Down	26133670
Intra	DCP1A	Q9NPI6	BAG4	Homo sapiens	O95429	Anti Tag CoIP	26496610
Intra	DCP1A	Q9NPI6	BAG4	Homo sapiens	O95429	IF	25036637
Intra	DCP1A	Q9NPI6	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	DCP1A	Q9NPI6	SMAD4	Homo sapiens	Q13485	Y2H	15231748
Intra	DCP1A	Q9NPI6	SMAD4	Homo sapiens	Q13485	BFG-2H	27107012
Intra	DCP1A	Q9NPI6	DDX6	Homo sapiens	P26196	Anti Tag CoIP	25036637
Intra	DCP1A	Q9NPI6	DDX6	Homo sapiens	P26196	Anti Tag CoIP	19966221
Intra	DCP1A	Q9NPI6	DDX6	Homo sapiens	P26196	Anti Tag CoIP	16364915
Intra	DCP1A	Q9NPI6	DDX6	Homo sapiens	P26196	Anti Tag CoIP	26496610
Intra	DCP1A	Q9NPI6	UPF1	Homo sapiens	Q92900	Confocal	19150429
Intra	DCP1A	Q9NPI6	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	12417715
Intra	DCP1A	Q9NPI6	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	19150429
Intra	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	19966221
Intra	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	16364915
Intra	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Validated Y2H	27107012
Intra	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Bait CoIP	16364915
Intra	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	26496610
Intra	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	24510189
Intra	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	19966221
Intra	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	23085078
Intra	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	16364915
Intra	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	IF	16364915
Intra	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	35271311
Intra	DCP1A	Q9NPI6	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	25036637
Intra	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	IF	12417715
Intra	DCP1A	Q9NPI6	ZFP36	Homo sapiens	P26651	Anti Tag CoIP	16364915
Intra	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	26496610
Intra	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Anti Tag CoIP	25036637
Intra	DCP1A	Q9NPI6	DCP2	Homo sapiens	Q8IU60	Pull Down	24510189
Intra	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	25036637
Intra	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	19966221
Intra	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	16364915
Intra	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	IF	16364915
Intra	DCP1A	Q9NPI6	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	35271311
Intra	DCP1A	Q9NPI6	FHL2	Homo sapiens	Q14192	Y2H Array	31515488
Intra	DCP1A	Q9NPI6	FHL2	Homo sapiens	Q14192	Y2H Array	25416956
Intra	DCP1A	Q9NPI6	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	25416956
Intra	DCP1A	Q9NPI6	PNRC2	Homo sapiens	Q9NPJ4	Anti Tag CoIP	24510189
Intra	DCP1A	Q9NPI6	PNRC2	Homo sapiens	Q9NPJ4	Validated Y2H	32296183
Intra	DCP1A	Q9NPI6	PNRC2	Homo sapiens	Q9NPJ4	Y2H Array	25416956
Intra	DCP1A	Q9NPI6	PNRC2	Homo sapiens	Q9NPJ4	Anti Tag CoIP	19150429

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03584	DCP1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DCP1A	VGNC	VGNC:71668
Canis familiaris	DCP1A	VGNC	VGNC:39808
Mus musculus	DCP1A	MGD	MGI:1923151
Rattus norvegicus	DCP1A	RGD	RGD:1561298
Bos taurus	DCP1A	VGNC	VGNC:27919
Felis catus	DCP1A	VGNC	VGNC:61372

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