Gpsm2 - G-protein signalling modulator 2 (AGS3-like, C. elegans) Gene

Mus musculus

Also known as LGN; Pins; 6230410J09Rik

Gene ID: 76123 | Gene type: protein coding

About Gpsm2

Summary

Enables G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Acts upstream of or within establishment of mitotic spindle orientation and lung epithelial cell differentiation. Located in apical part of cell and lateral cell cortex. Is expressed in several structures, including gonad; lung; nervous system; sensory organ; and spleen. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human GPSM2 (G protein signaling modulator 2). [provided by Alliance of Genome Resources, Apr 2022]

Gpsm2 Products(1)

mRNA	Protein	Name
NM_029522.2	NP_083798.2	G-protein-signaling modulator 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	22952234	MGI
enables GDP-dissociation inhibitor activity	IDA IDA: Inferred from direct assay	22952234	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22117215	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in lateral cell cortex	IDA IDA: Inferred from direct assay	26766442	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

G-protein-signaling modulator 2

pins homolog (Drosophia)

Gpsm2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Gpsm2	Q8VDU0	NUMA1	Homo sapiens	Q14980-2	ITC	23665171
Cross	Gpsm2	Q8VDU0	NUMA1	Homo sapiens	Q14980-2	FPS	23665171
Cross	Gpsm2	Q8VDU0	DLG4	Homo sapiens	P78352	FPS	22117215
Cross	Gpsm2	Q8VDU0	Dlg1	Rattus norvegicus	Q62696	Anti Tag CoIP	22117215
Cross	Gpsm2	Q8VDU0	Dlg1	Rattus norvegicus	Q62696	FPS	22117215
Cross	Gpsm2	Q8VDU0	Dlg1	Rattus norvegicus	Q62696	Pull Down	22117215

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05760	GPSM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpsm2	NCBI	NCBI:29899

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