Dlg1 - discs large MAGUK scaffold protein 1 Gene

Rattus norvegicus

Also known as Dlgh1; SAP97

Gene ID: 25252 | Gene type: protein coding

About Dlg1

Summary

Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and Kinesin binding activity. Involved in several processes, including cell adhesion; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and paranode region of axon. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dlg1 Products(2)

mRNA	Protein	Name
NM_001393734.1	NP_001380663.1	disks large homolog 1 isoform 2
NM_012788.2	NP_036920.2	disks large homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15024025	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	14597197	RGD
enables kinesin binding	IPI IPI: Inferred from physical interaction	12097473	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	1127911	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12933808	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	11181181	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IEP IEP: Inferred from expression pattern	7891172	RGD
involved in cellular response to brain-derived neurotrophic factor stimulus	IDA IDA: Inferred from direct assay	14597197	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	14597197	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	12805297	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	12805297	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	14597197	RGD
involved in positive regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	19213956	RGD
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	17635915	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	11181181	RGD
located in basal plasma membrane	IDA IDA: Inferred from direct assay	7891172	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11726633	RGD
located in cytosol	IDA IDA: Inferred from direct assay	19587293	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17301176	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11029631	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12805297	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	8638125	RGD
located in microvillus	IDA IDA: Inferred from direct assay	19587293	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8638125	RGD
located in paranode region of axon	IDA IDA: Inferred from direct assay	19587293	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	17301176	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	11029631	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	7891172	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	8638125	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disks large homolog 1

Drosophila discs-large tumor suppressor homologue (synapse associated protein)	discs large homolog 1, scribble cell polarity complex component
discs, large homolog 1	synapse-associated protein 97

Dlg1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Dlg1	Q62696	DLGAP1	Homo sapiens	O14490	FPS	22117215
Cross	Dlg1	Q62696	BTRC	Homo sapiens	Q9Y297	Pull Down	12902344
Intra	Dlg1	Q62696	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	21119615
Intra	Dlg1	Q62696	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	16332687
Intra	Dlg1	Q62696	Map1a	Rattus norvegicus	P34926	Far-WB	9786987
Cross	Dlg1	Q62696	PTEN	Homo sapiens	P60484	Pull Down	15951562
Intra	Dlg1	Q62696	Kcnj2	Rattus norvegicus	Q64273	Anti Bait CoIP	22509027
Cross	Dlg1	Q62696	E4	Human adenovirus D	P89079	Anti Tag CoIP	16511562
Cross	Dlg1	Q62696	E4	Human adenovirus D	P89079	Anti Bait CoIP	9192623
Cross	Dlg1	Q62696	Gpsm2	Mus musculus	Q8VDU0	FPS	22117215
Cross	Dlg1	Q62696	Gpsm2	Mus musculus	Q8VDU0	X-Ray Diffraction	22117215
Intra	Dlg1	Q62696	Dgki	Rattus norvegicus	F1MAB7	Anti Bait CoIP	21119615
Intra	Dlg1	Q62696	Dgki	Rattus norvegicus	F1MAB7	Pull Down	21119615
Intra	Dlg1	Q62696	Lrfn2	Rattus norvegicus	Q460M5	Anti Bait CoIP	16495444

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03796	DLG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlg1	NCBI	NCBI:1739

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