ZKSCAN8 - zinc finger with KRAB and SCAN domains 8 Gene

Homo sapiens

Also known as LD5-1; ZNF192; ZSCAN40

Gene ID: 7745 | Gene type: protein coding

About ZKSCAN8

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:28,141,635-28,159,460 (from NCBI)

This gene has 4 transcripts (splice variants), 94 orthologues and 31 paralogues. Ubiquitous expression in endometrium (RPKM 9.3), ovary (RPKM 8.6) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZKSCAN8 Products(4)

mRNA	Protein	Name
NM_001278119.2	NP_001265048.1	zinc finger protein with KRAB and SCAN domains 8 isoform 1
NM_001278121.2	NP_001265050.1	zinc finger protein with KRAB and SCAN domains 8 isoform 2
NM_001278122.2	NP_001265051.1	zinc finger protein with KRAB and SCAN domains 8 isoform 2
NM_006298.4	NP_006289.2	zinc finger protein with KRAB and SCAN domains 8 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZKSCAN8 Protein Structure

SCAN

KRAB

zf-C2H2_6

zf-H2C2_2

0
100
200
300
400
500
578 a.a.

Protein Preferred Names

Protein Names

zinc finger protein with KRAB and SCAN domains 8

zinc finger protein 192

ZKSCAN8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZKSCAN8	Q15776	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	ZNF444	Homo sapiens	Q8N0Y2-2	Validated Y2H	32296183
Intra	ZKSCAN8	Q15776	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	ZKSCAN8	Q15776	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	ZKSCAN8	Q15776	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	ZKSCAN8	Q15776	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	ZKSCAN8	Q15776	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16083	ZKSCAN8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZKSCAN8	MGD	MGI:1913815
Rattus norvegicus	ZKSCAN8	RGD	RGD:1308983
Canis familiaris	ZKSCAN8	VGNC	VGNC:49668
Bos taurus	ZKSCAN8	VGNC	VGNC:107041
Felis catus	ZKSCAN8	VGNC	VGNC:67250
Macaca mulatta	ZKSCAN8	VGNC	VGNC:78417

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