ZP2 - zona pellucida glycoprotein 2 Gene

Homo sapiens

Also known as ZPA; Zp-2; OOMD6

Gene ID: 7783 | Gene type: protein coding

About ZP2

Cytogenetic location: 16p12.3-p12.2 Genomic coordinates (GRCh38): 16:21,197,450-21,214,510 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 218 orthologues, 4 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

ZP2 Products(4)

mRNA	Protein	Name
NM_001376231.1	NP_001363160.1	zona pellucida sperm-binding protein 2 isoform 2 preproprotein
NM_001376232.1	NP_001363161.1	zona pellucida sperm-binding protein 2 isoform 1 preproprotein
NM_001376233.1	NP_001363162.1	zona pellucida sperm-binding protein 2 isoform 3 preproprotein
NM_003460.2	NP_003451.1	zona pellucida sperm-binding protein 2 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acrosin binding	IPI IPI: Inferred from physical interaction	15950651	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26879157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15950651	GOA
enables structural constituent of egg coat	IMP IMP: Inferred from mutant phenotype	29895852	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in regulation of acrosome reaction	IDA IDA: Inferred from direct assay	11751269	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in egg coat	IDA IDA: Inferred from direct assay	29895852	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZP2 Protein Structure

Zona_pellucida

0
200
400
600
745 a.a.

Protein Preferred Names

Protein Names

zona pellucida sperm-binding protein 2

zona pellucida 2

ZP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZP2	Q05996	VDAC2	Homo sapiens	P45880-3	Pull Down	23355646
Intra	ZP2	Q05996	VDAC2	Homo sapiens	P45880-3	Far-WB	23355646
Intra	ZP2	Q05996	ZP2	Homo sapiens	Q05996	IR Spectrometry	26879157
Intra	ZP2	Q05996	ACR	Homo sapiens	P10323	ELISA	15950651
Intra	ZP2	Q05996	PKM	Homo sapiens	P14618-2	Far-WB	23355646
Intra	ZP2	Q05996	GPX4	Homo sapiens	P36969	Far-WB	23355646
Intra	ZP2	Q05996	ZP2	Homo sapiens	Q05996	EM	26879157
Intra	ZP2	Q05996	ZP2	Homo sapiens	Q05996	X-Ray Diffraction	26879157
Intra	ZP2	Q05996	FAR2	Homo sapiens	Q96K12	Anti Tag CoIP	33961781
Intra	ZP2	Q05996	PLCG1	Homo sapiens	P19174	Peptide Array	17474147
Intra	ZP2	Q05996	P10323-PRO_0000027518	Homo sapiens	P10323-PRO_0000027518	ELISA	15950651
Intra	ZP2	Q05996	ENO1	Homo sapiens	P06733	Far-WB	23355646
Intra	ZP2	Q05996	GAPDHS	Homo sapiens	O14556	Far-WB	23355646

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oocyte Maturation Defect 6

OOMD6

Female Infertility Due To Zona Pellucida Defect

Infertility

Acheiropody

Acheiropodia	ACHP
Acheiropody, Brazilian Type	Horn-Kolb Syndrome
Horn Kolb Syndrome	Acheiropody Brazilian Type

Syndactyly, Type Iv

Syndactyly Type 4	Polysyndactyly, Haas Type
SDTY4	Haas Type Syndactyly
Sd4	Polysyndactyly Type Haas
Syndactyly 4	Polysyndactyly Haas Type
Syndactyly Type Iv

Tibia, Hypoplasia Or Aplasia Of, With Polydactyly

Hypoplastic Or Aplastic Tibia With Polydactyly	Absence Of Tibia With Polydactyly
Tibial Hemimelia-Polysyndactyly-Triphalangeal Thumb Syndrome	THYP
Tibial Hemimelia-Polydactyly-Triphalangeal Thumbs With Fibular Dimelia	Absent Tibia-Polydactyly Syndrome
Werner Mesomelic Syndrome	Hypoplastic Tibiae-Postaxial Polydactyly Syndrome
Polydactyly With Absent Tibia	Werner Mesomelic Spectrum
Hypoplasia Or Aplasia Of Tibia With Polydactyly	Wms
Tibia, Hypoplasia Of, With Polydactyly

Joubert Syndrome 32

JBTS32

Zygodactyly 1

Zd1	Zygodactyly Type 1
Sd1, Weidenreich Type	Sd1a
Syndactyly Type 1, Weidenreich Type	Syndactyly Type 1a
Zygodactyly, Weidenreich Type

Chromosome 2q35 Duplication Syndrome

Syndactyly	Syndactyly Type 1
Sdty1	Zygodactyly
Syndactyly, Type I	Sd1
Syndactyly, Type 1, With Or Without Craniosynostosis	Symphalangism
Non-Syndromic Syndactyly	Symphalangy
Webbing Of Digits	Syndactyly, Type 1

Laurin-Sandrow Syndrome

Sandrow Syndrome	Tetramelic Mirror-Image Polydactyly
Mirror-Image Polydactyly	Mirror Hands And Feet With Nasal Defects
Tmip	LSS
Mip	Mirror Hands And Feets-Nasal Defects Syndrome
Fibula And Ulna, Duplication Of, With Absence Of Tibia And Radius	Miccor Hands And Feet With Nasal Defects
Mipduplication Of Fibuland Ulna With Absence Of Tibia And Radius	Fibula Ulna Duplication Tibia Radius Absence
Laurin Sandrow Syndrome	Duplication Of Fibula And Ulna With Absence Of Tibia And Radius
Segmental Laurin-Sandrow Syndrome	Laurin-Sandrow Syndrome, Segmental

Epilepsy, Idiopathic Generalized 2

EIG2	Epilepsy, Idiopathic Generalized, Susceptibility To, 2
Idiopathic Generalized Epilepsy 2	Epilepsy, Idiopathic Generalized Locus On Chromosome 14
Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 14

Cataract 1, Multiple Types

Cataract 1 Multiple Types	CTRCT1
Cataract 1, Multiple Types, With Or Without Microcornea	Czp1
Cae1	Pulverulent Zonular Cataract
Cataract, Duffy-Linked	Cataract, Zonular Pulverulent, 1
Duffy Linked Cataract	Zonular Pulverulent Cataract 1
Cataract Duffy-Linked	Cataract-Microcornea Syndrome
Cataract Zonular Pulverulent 1	Ccmc
Cznp	Czp
Zonular Nuclear Pulverulent Cataract	Cataract, Zonular Pulverulent-1
Zonular Pulverulent Cataract	Cataract, Zonular Pulverulent 1
Cataract Microcornea Syndrome

Syndactyly, Type Iii

Syndactyly Type 3	SDTY3
Ring And Little Finger Syndactyly	Syndactyly Of Fingers Iv And V
Syndactyly Of Fingers 4 And 5	Ringand Little Finger Syndactyly
Syndactyly Of Fingers Four And Five	Syndactyly Of The Ring And Little Finger
Sd3	Syndactyly 3
Syndactyly Type Iii	4-5 Finger Syndactyly
Syndactyly, Type 3

Greig Cephalopolysyndactyly Syndrome

GCPS	Polysyndactyly With Peculiar Skull Shape
Polysyndactyly With Peculiars Skull Shape	Greig Syndrome
Cephalopolysyndactyly Syndrome	Greig Cephalo-Poly-Syndactyly Syndrome
Cephalopolysyndactyly, Greig Syndrome	Aarskog Syndrome

Megalencephalic Leukoencephalopathy With Subcortical Cysts 1

Van Der Knaap Disease	Leukoencephalopathy With Swelling And Cysts
MLC1	Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts
Lvm	Vl
Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1
Megalencephalic Leukoencephalopathy With Subcortical Cysts

Pallister-Hall Syndrome

PHS	Hypothalamic Hamartomas
Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly	Hypothalamic Hamartoblastoma Syndrome
Hamartoma Of The Hypothalamus	Pallister Hall Syndrome
Hall-Pallister Syndrome	Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly
Hamartoma, Hypothalamic

Synpolydactyly

Syndactyly Type 2	Syndactyly, Type 2
Spd

Duane-Radial Ray Syndrome

Okihiro Syndrome	DRRS
Dr Syndrome	Duane Anomaly With Radial Ray Abnormalities And Deafness
Acrorenoocular Syndrome	Acrorenocular Syndrome
Duane Anomaly With Radial Abnormalities And Deafness	Acro-Renal-Ocular Syndrome

Split Hand-Foot Malformation

Ectrodactyly	Split-Hand/Foot Malformation
Lobster-Claw Deformity	Split-Hand Deformity
Split Hand Foot Malformation	Shfm
Split Hand Foot Deformity	Split Hand Foot Deformity 1

Synostosis

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Chromosomal Duplication Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16187	ZP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZP2	VGNC	VGNC:78914
Canis familiaris	ZP2	VGNC	VGNC:48842
Rattus norvegicus	ZP2	RGD	RGD:620605
Felis catus	ZP2	VGNC	VGNC:80708
Bos taurus	ZP2	VGNC	VGNC:37366
Mus musculus	ZP2	MGD	MGI:99214

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