ZP3 - zona pellucida glycoprotein 3 Gene

Homo sapiens

Also known as ZPC; ZP3A; ZP3B; Zp-3; OOMD3

Gene ID: 7784 | Gene type: protein coding

About ZP3

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:76,397,522-76,442,069 (from NCBI)

This gene has 7 transcripts (splice variants), 839 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 5.0), skin (RPKM 3.3) and 25 other tissues.

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus Furin cleavage site, and a transmembrane domain. It is hypothesized that Furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for Furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

ZP3 Products(2)

mRNA	Protein	Name
NM_001110354.2	NP_001103824.1	zona pellucida sperm-binding protein 3 isoform 1 precursor
NM_007155.6	NP_009086.4	zona pellucida sperm-binding protein 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acrosin binding	IPI IPI: Inferred from physical interaction	15950651	GOA
enables carbohydrate binding	IDA IDA: Inferred from direct assay	19246320	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26879157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15950651	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in binding of sperm to zona pellucida	IDA IDA: Inferred from direct assay	19246320	GOA
involved in binding of sperm to zona pellucida	IGI IGI: Inferred from genetic interaction	9609824	GOA
involved in binding of sperm to zona pellucida	IMP IMP: Inferred from mutant phenotype	19004505	GOA
involved in negative regulation of binding of sperm to zona pellucida	IDA IDA: Inferred from direct assay	18667750	GOA
involved in positive regulation of acrosomal vesicle exocytosis	IDA IDA: Inferred from direct assay	19246320	GOA
involved in positive regulation of acrosomal vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	19004505	GOA
involved in positive regulation of acrosome reaction	IDA IDA: Inferred from direct assay	11751269	GOA
involved in positive regulation of humoral immune response	IDA IDA: Inferred from direct assay	19004505	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	19246320	GOA
located in egg coat	IDA IDA: Inferred from direct assay	29895852	GOA
located in extracellular space	IMP IMP: Inferred from mutant phenotype	19246320	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZP3 Protein Structure

Zona_pellucida

0
100
200
300
400
424 a.a.

Protein Preferred Names

Protein Names

zona pellucida sperm-binding protein 3

ZP3A/ZP3B

ZP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZP3	P21754	VDAC2	Homo sapiens	P45880-3	Far-WB	23355646
Intra	ZP3	P21754	VDAC2	Homo sapiens	P45880-3	Pull Down	23355646
Intra	ZP3	P21754	SPACA3	Homo sapiens	Q8IXA5	Gal4 VP16 Complement	19945174
Intra	ZP3	P21754	UBAP2L	Homo sapiens	Q14157	Gal4 VP16 Complement	19945174
Intra	ZP3	P21754	ZP3	Homo sapiens	P21754	X-Ray Diffraction	26879157
Intra	ZP3	P21754	PCDH17	Homo sapiens	O14917	Gal4 VP16 Complement	19945174
Intra	ZP3	P21754	ENO1	Homo sapiens	P06733	Far-WB	23355646
Intra	ZP3	P21754	GPX4	Homo sapiens	P36969	Far-WB	23355646
Intra	ZP3	P21754	ACR	Homo sapiens	P10323	ELISA	15950651
Intra	ZP3	P21754	PKM	Homo sapiens	P14618-2	Far-WB	23355646
Intra	ZP3	P21754	MICALL1	Homo sapiens	Q8N3F8	Gal4 VP16 Complement	19945174
Intra	ZP3	P21754	GAPDHS	Homo sapiens	O14556	Far-WB	23355646
Intra	ZP3	P21754	GSTM3	Homo sapiens	P21266	Far-WB	23355646
Intra	ZP3	P21754	ZP3	Homo sapiens	P21754	EM	26879157
Intra	ZP3	P21754	PCDH17	Homo sapiens	O14917	Y2H	19945174
Intra	ZP3	P21754	ODF2	Homo sapiens	Q5BJF6-5	Far-WB	23355646
Intra	ZP3	P21754	ZP3	Homo sapiens	P21754	IR Spectrometry	26879157
Intra	ZP3	P21754	SPACA3	Homo sapiens	Q8IXA5	Y2H	19945174
Intra	ZP3	P21754	P10323-PRO_0000027518	Homo sapiens	P10323-PRO_0000027518	ELISA	15950651
Intra	ZP3	P21754	MICALL1	Homo sapiens	Q8N3F8	Y2H	19945174
Intra	ZP3	P21754	UBAP2L	Homo sapiens	Q14157	Y2H	19945174

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71672	ZP3 Protein, Human (HEK293, His)	P21754 (23Q-387V)	≥95%

Related Diseases

Diseases

Alias

Oocyte Maturation Defect 3

OOMD3

Oocyte Maturation Defect, Type 3

Female Infertility Due To Zona Pellucida Defect

Infertility

Ovarian Disease

Ovarian Dysfunction	Ovarian Diseases
Ovarian Disorders	Disorder Of Endocrine Ovary

Epilepsy, Familial Temporal Lobe, 4

ETL4	Epilepsy, Occipitotemporal Lobe, And Migraine With Aura
Epolm	Familial Temporal Lobe Epilepsy 4
Occipitotemporal Lobe Epilepsy And Migraine With Aura

Ovarian Dysgenesis 2

Premature Ovarian Failure 4	ODG2
Ovarian Dysgenesis, Hypergonadotropic, X-Linked	Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis
Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis	X-Linked Hypergonadotropic Ovarian Dysgenesis
POF4	Dysgenesis, Ovarian, Type 2

Cataract 1, Multiple Types

Cataract 1 Multiple Types	CTRCT1
Cataract 1, Multiple Types, With Or Without Microcornea	Czp1
Cae1	Pulverulent Zonular Cataract
Cataract, Duffy-Linked	Cataract, Zonular Pulverulent, 1
Duffy Linked Cataract	Zonular Pulverulent Cataract 1
Cataract Duffy-Linked	Cataract-Microcornea Syndrome
Cataract Zonular Pulverulent 1	Ccmc
Cznp	Czp
Zonular Nuclear Pulverulent Cataract	Cataract, Zonular Pulverulent-1
Zonular Pulverulent Cataract	Cataract, Zonular Pulverulent 1
Cataract Microcornea Syndrome

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Gaucher Disease, Type Iiic

Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome	Gaucher-Like Disease
GD3C	Gaucher'S Disease Type Iiic
Cardiovascular Gaucher Disease	Gaucher Disease Type 3c
Gaucher Disease 3c	Pseudo-Gaucher Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16188	ZP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZP3	VGNC	VGNC:108456
Felis catus	ZP3	VGNC	VGNC:107838
Mus musculus	ZP3	MGD	MGI:99215
Rattus norvegicus	ZP3	RGD	RGD:620606
Others	ZP3	NCBI

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