2. Gene
  3. ZFYVE21 - zinc finger FYVE-type containing 21 Gene

ZFYVE21 - zinc finger FYVE-type containing 21 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ZF21; HCVP7TP1

Gene ID: 79038 | Gene type: protein coding

About ZFYVE21

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,715,810-103,733,664 (from NCBI)

This gene has 12 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in fat (RPKM 36.0), endometrium (RPKM 31.2) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Predicted to be located in endosome and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

ZFYVE21 Products(2)

mRNA Protein Name
NM_001198953.2 NP_001185882.1 zinc finger FYVE domain-containing protein 21 isoform 1
NM_024071.4 NP_076976.1 zinc finger FYVE domain-containing protein 21 isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE21 Protein Structure

FYVE

FYVE: FYVE zinc finger (39 - 100)

  • 0
  • 100
  • 200
  • 234 a.a.
Protein Preferred Names Protein Names

zinc finger FYVE domain-containing protein 21

FYVE domain containing 21

ZFYVE21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ZFYVE21 Q9BQ24 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
Intra ZFYVE21 Q9BQ24 RTN4 Homo sapiens Q9NQC3-2
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 RTN4 Homo sapiens Q9NQC3-2
Y2H Prey Pooling
25416956
Intra ZFYVE21 Q9BQ24 KRT38 Homo sapiens O76015
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 KRT38 Homo sapiens O76015
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 PDE4DIP Homo sapiens Q5VU43
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 PDE4DIP Homo sapiens Q5VU43
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 SMIM5 Homo sapiens Q71RC9
Y2H Array
32296183
Intra ZFYVE21 Q9BQ24 SMIM5 Homo sapiens Q71RC9
Y2H Prey Pooling
32296183
Intra ZFYVE21 Q9BQ24 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
Intra ZFYVE21 Q9BQ24 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
Intra ZFYVE21 Q9BQ24 CMTM4 Homo sapiens Q8IZR5-2
Y2H Array
32296183
Intra ZFYVE21 Q9BQ24 CMTM4 Homo sapiens Q8IZR5-2
Y2H Prey Pooling
32296183
Intra ZFYVE21 Q9BQ24 YIF1A Homo sapiens O95070
Y2H Array
32296183
Intra ZFYVE21 Q9BQ24 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
Intra ZFYVE21 Q9BQ24 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra ZFYVE21 Q9BQ24 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra ZFYVE21 Q9BQ24 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra ZFYVE21 Q9BQ24 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra ZFYVE21 Q9BQ24 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
32296183
Intra ZFYVE21 Q9BQ24 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
Intra ZFYVE21 Q9BQ24 RABAC1 Homo sapiens Q9UI14
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 RABAC1 Homo sapiens Q9UI14
Y2H Array
32296183
Intra ZFYVE21 Q9BQ24 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
25416956
Intra ZFYVE21 Q9BQ24 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
Intra ZFYVE21 Q9BQ24 ARL6IP1 Homo sapiens Q15041
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
Intra ZFYVE21 Q9BQ24 ARL6IP1 Homo sapiens Q15041
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 RTN4 Homo sapiens Q9NQC3
Y2H Prey Pooling
25416956
Intra ZFYVE21 Q9BQ24 RTN4 Homo sapiens Q9NQC3
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 AGTRAP Homo sapiens Q6RW13
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 AGTRAP Homo sapiens Q6RW13
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Intra ZFYVE21 Q9BQ24 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 REEP6 Homo sapiens Q96HR9
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra ZFYVE21 Q9BQ24 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra ZFYVE21 Q9BQ24 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra ZFYVE21 Q9BQ24 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra ZFYVE21 Q9BQ24 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra ZFYVE21 Q9BQ24 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16058 ZFYVE21 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZFYVE21 MGD MGI:1915770
Felis catus ZFYVE21 VGNC VGNC:67240
Rattus norvegicus ZFYVE21 RGD RGD:1311036
Canis familiaris ZFYVE21 VGNC VGNC:48625
Bos taurus ZFYVE21 VGNC VGNC:55897
Macaca mulatta ZFYVE21 VGNC VGNC:79282