2. Gene
  3. FTO - FTO alpha-ketoglutarate dependent dioxygenase Gene

FTO - FTO alpha-ketoglutarate dependent dioxygenase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GDFD; ALKBH9; BMIQ14

Gene ID: 79068 | Gene type: protein coding

About FTO

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:53,703,963-54,121,941 (from NCBI)

This gene has 23 transcripts (splice variants), 202 orthologues and is associated with 4 phenotypes. Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.2) and 25 other tissues.

Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron Enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

FTO Products(25)

mRNA Protein Name
XM_011523316.4 XP_011521618.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X6
NM_001363896.1 NP_001350825.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 4
NM_001363905.1 NP_001350834.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 11
XR_007064911.1
NR_156761.1
NM_001363894.1 NP_001350823.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 1
XM_017023654.3 XP_016879143.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X1
XM_047434607.1 XP_047290563.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X3
NM_001363898.1 NP_001350827.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 6
NM_001080432.3 NP_001073901.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 3
NM_001363900.1 NP_001350829.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 8
XM_011523315.4 XP_011521617.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X5
XM_017023656.3 XP_016879145.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X7
NM_001363901.1 NP_001350830.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 9
XM_047434606.1 XP_047290562.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X2
XM_047434609.1 XP_047290565.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
NM_001363891.1 NP_001350820.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 2
XM_011523314.4 XP_011521616.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X4
XM_024450437.2 XP_024306205.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X9
NM_001363903.1 NP_001350832.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 10
NM_001363988.1 NP_001350917.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 12
NM_001363897.1 NP_001350826.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 5
NM_001363899.1 NP_001350828.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 7
XM_017023657.3 XP_016879146.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
XM_047434608.1 XP_047290564.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X5

FTO Protein Structure

FTO_NTD

FTO_NTD: FTO catalytic domain (35 - 326)

FTO_CTD

FTO_CTD: FTO C-terminal domain (329 - 499)

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  • 505 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase FTO

AlkB homolog 9

U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

fat mass and obesity associated

fat mass and obesity-associated protein

m6A(m)-demethylase FTO

mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

mRNA N(6)-methyladenosine demethylase FTO

tRNA N1-methyl adenine demethylase FTO

Related Diseases

Diseases Alias
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Growth Retardation, Developmental Delay, And Facial Dysmorphism

Lethal Polymalformative Syndrome, Boissel Type

Growth Retardation, Developmental Delay, Coarse Facies, And Early Death

GDFD

Growth Retardation, Developmental Delay, Facial Dysmorphism

Growth Retardation Developmental Delay Coarse Facies Early Death

Lethal Polymalformative Syndrome Boissel Type
Acquired Metabolic Disease
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Body Mass Index Quantitative Trait Locus 14

Obesity

BMIQ14

Obesity, Susceptibility To

Obesity, Susceptibility To, Bmiq14

Obesity Bmiq14

{Obesity, Susceptibility To, Bmiq14}
Eating Disorder

Eating Disorders

Feeding And Eating Disorders
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Overnutrition
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Diabetes Mellitus

Diabetes
Glucose Intolerance

Glucose: Intolerance

Glucose: Malabsorption

Malabsorption Of Glucose

Impaired Glucose Tolerance
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Cervix Carcinoma

Cancer Of Cervix

Carcinoma Of Cervix

Carcinoma Cervix Uteri

Carcinoma Of The Cervix Uteri
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction

Leptin
Adult Spinal Cord Glioblastoma Multiforme

Glioblastoma Multiforme Of Spinal Cord

Adult Spinal Cord Glioblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-B1320 Meclofenamic acid sodium Inhibitor 99.86% Unkown
HY-117275 Meclofenamic acid Inhibitor 98.60% Unkown
HY-101082 N6,2′-O-Dimethyladenosine Inhibitor 99.93% Unkown
HY-117275A Meclofenamic acid sodium hydrate Inhibitor / Unkown
HY-14280R Entacapone (Standard) Inhibitor / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-127103 FB23-2 Inducer 99.93% Unkown
HY-137187 FB23 98.66% Unkown
HY-N6769 Radicicol Inhibitor 99.63% Unkown
HY-151106 FTO-IN-8 Inhibitor 98.03% Unkown
HY-145238 FTO-IN-6 98.94% Unkown
HY-149334 ZLD115 Inhibitor 99.24% Unkown
HY-138843A FTO-IN-1 TFA 98.04% Unkown
HY-132865 FTO-IN-3 99.79% Unkown
HY-147011 FTO-IN-7 Inhibitor 99.22% Unkown
HY-RS05137 Fto Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W588293 3-Methylthymidine 99.68% Unkown
HY-14280S Entacapone-d10 Inhibitor ≥98.0% Unkown
HY-117275S Meclofenamic acid-d4 Inhibitor / Unkown
HY-117275S1 Meclofenamic acid-13C6 Inhibitor / Unkown
HY-117426 MO-I-500 Inhibitor 99.10% Unkown
HY-132863 FTO-IN-2 / Unkown
HY-138843 FTO-IN-1 / Unkown
HY-139820 FTO-IN-4 / Unkown
HY-139821 FTO-IN-5 / Unkown
HY-156405 FTO-IN-10 / Unkown
HY-N10340 Clausine E Inhibitor / Unkown
HY-RS05136 FTO Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05138 Fto Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W026109 FTO-IN-12 Inhibitor / Unkown
HY-131871 Ethyl LipotF Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FTO VGNC VGNC:29138
Canis familiaris FTO VGNC VGNC:41003
Rattus norvegicus FTO RGD RGD:1305121
Felis catus FTO VGNC VGNC:62384
Macaca mulatta FTO VGNC VGNC:72772
Mus musculus FTO MGD MGI:1347093
Others FTO NCBI