Meclofenamic acid sodium (Synonyms: Meclofenamate sodium)

Name: Meclofenamic acid sodium
Brand: MedChemExpress
SKU: HY-B1320
Rating: 5.0 (5 reviews)

Cat. No.: HY-B1320 Purity: 99.70%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities.

For research use only. We do not sell to patients.

Meclofenamic acid sodium Chemical Structure

CAS No. : 6385-02-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 99	In-stock	Estimated Time of Arrival: December 31
200 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Based on 5 publication(s) in Google Scholar

Other Forms of Meclofenamic acid sodium:

Meclofenamic acid Get quote
Meclofenamic acid sodium hydrate Get quote
Meclofenamic acid sodium (Standard) Get quote

4 Publications Citing Use of MCE Meclofenamic acid sodium

: Meclofenamic acid sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jul 25;11(17):8464-8479. [Abstract]; The effect of FTO inhibitor Meclofenamate sodium (MS) (80 μM and 120 μM) on ATF4 protein expression and mTORC1 activity during 968 treatment is detected by western blotting. MS efficiently reduces ATF4 expression and rescues the mTOR downregulation induced by compound 968.

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Description

In Vitro

Meclofenamic acid sodium (10, 100, 200 mM, 4 days) inhibits the proliferation and migration of haSMCs^[1].
Meclofenamic acid sodium (4, 6 μM, 48 h) combines with gefitinib-induced caspase-related apoptosis of resistant NSCLC cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	haSMCs
Concentration:	10, 100, 200 mM
Incubation Time:	4 days
Result:	Caused a G2/M-phase block

Western Blot Analysis^[1]

Cell Line:	haSMCs
Concentration:	10, 100, 200 mM
Incubation Time:	4 days
Result:	Decreased the expression of p44/42 MAPK.

In Vivo

Meclofenamic acid sodium (10 mg/kg/day, intraperitoneally injected for 20 days) shows antitumor activity in mouse prostate tumor model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Prostate tumor model in mice^[2]
Dosage:	10 mg/kg
Administration:	i.p.
Result:	Decreased tumor aggression, increased fibrosis, cellular proliferation and vascularity reduction.

Clinical Trial

Molecular Weight

318.13

Formula

C₁₄H₁₀Cl₂NNaO₂

CAS No.

6385-02-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (392.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (314.34 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1434 mL	15.7168 mL	31.4337 mL
5 mM	0.6287 mL	3.1434 mL	6.2867 mL
10 mM	0.3143 mL	1.5717 mL	3.1434 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (280 KB) SDS (394 KB)

COA (251 KB) HNMR (264 KB) LCMS (129 KB)

Handling Instructions (2659 KB)

References

[1]. Schober W, et al. Meclofenamic acid for inhibition of human vascular smooth muscle cell proliferation and migration: an in vitro study. Cardiovasc Intervent Radiol. 2002 Jan-Feb;25(1):57-63. [Content Brief]

[2]. Chen H, et al. Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer. Front Oncol. 2022 Apr 21;12:870636. [Content Brief]

[3]. Schrier DJ, et al. The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice. J Pharm Pharmacol. 1987 Jan;39(1):57-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.1434 mL	15.7168 mL	31.4337 mL	78.5842 mL
	5 mM	0.6287 mL	3.1434 mL	6.2867 mL	15.7168 mL
	10 mM	0.3143 mL	1.5717 mL	3.1434 mL	7.8584 mL
	15 mM	0.2096 mL	1.0478 mL	2.0956 mL	5.2389 mL
	20 mM	0.1572 mL	0.7858 mL	1.5717 mL	3.9292 mL
	25 mM	0.1257 mL	0.6287 mL	1.2573 mL	3.1434 mL
	30 mM	0.1048 mL	0.5239 mL	1.0478 mL	2.6195 mL
	40 mM	0.0786 mL	0.3929 mL	0.7858 mL	1.9646 mL
	50 mM	0.0629 mL	0.3143 mL	0.6287 mL	1.5717 mL
	60 mM	0.0524 mL	0.2619 mL	0.5239 mL	1.3097 mL
	80 mM	0.0393 mL	0.1965 mL	0.3929 mL	0.9823 mL
	100 mM	0.0314 mL	0.1572 mL	0.3143 mL	0.7858 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Meclofenamic acid sodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meclofenamic acid6385-02-0MeclofenamateGap Junction ProteinEndogenous MetaboliteFat Mass and Obesity-associated Protein (FTO)Anti-inflammatoryAntitumorPC9H292haSMCsProstate tumorInhibitorinhibitorinhibit

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Meclofenamic acid sodium (Synonyms: Meclofenamate sodium)

Customer Review

Other Forms of Meclofenamic acid sodium:

Meclofenamic acid sodium Related Antibodies

4 Publications Citing Use of MCE Meclofenamic acid sodium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Meclofenamic acid sodium Related Antibodies

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Complete Stock Solution Preparation Table

Meclofenamic acid sodium Related Classifications

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