2. Cytoskeleton Metabolic Enzyme/Protease
  3. Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)
  4. Meclofenamic acid sodium

Meclofenamic acid sodium  (Synonyms: Meclofenamate sodium)

Cat. No.: HY-B1320 Purity: 99.70%
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Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities.

For research use only. We do not sell to patients.

Meclofenamic acid sodium Chemical Structure

Meclofenamic acid sodium Chemical Structure

CAS No. : 6385-02-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid
50 mg USD 55 In-stock
100 mg USD 99 In-stock
200 mg USD 165 In-stock
500 mg   Get quote  
1 g   Get quote  

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Based on 5 publication(s) in Google Scholar

Other Forms of Meclofenamic acid sodium:

Meclofenamic acid sodium Related Antibodies

Top Publications Citing Use of Products

    Meclofenamic acid sodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jul 25;11(17):8464-8479.  [Abstract]

    The effect of FTO inhibitor Meclofenamate sodium (MS) (80 μM and 120 μM) on ATF4 protein expression and mTORC1 activity during 968 treatment is detected by western blotting. MS efficiently reduces ATF4 expression and rescues the mTOR downregulation induced by compound 968.

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    Description

    Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities[1][2][3].

    In Vitro

    Meclofenamic acid sodium (10, 100, 200 mM, 4 days) inhibits the proliferation and migration of haSMCs[1].
    Meclofenamic acid sodium (4, 6 μM, 48 h) combines with gefitinib-induced caspase-related apoptosis of resistant NSCLC cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Meclofenamic acid sodium Related Antibodies

    Cell Cycle Analysis[1]

    Cell Line: haSMCs
    Concentration: 10, 100, 200 mM
    Incubation Time: 4 days
    Result: Caused a G2/M-phase block

    Western Blot Analysis[1]

    Cell Line: haSMCs
    Concentration: 10, 100, 200 mM
    Incubation Time: 4 days
    Result: Decreased the expression of p44/42 MAPK.
    In Vivo

    Meclofenamic acid sodium (10 mg/kg/day, intraperitoneally injected for 20 days) shows antitumor activity in mouse prostate tumor model[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Prostate tumor model in mice[2]
    Dosage: 10 mg/kg
    Administration: i.p.
    Result: Decreased tumor aggression, increased fibrosis, cellular proliferation and vascularity reduction.
    Clinical Trial
    Molecular Weight

    318.13

    Formula

    C14H10Cl2NNaO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Na])C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (392.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 100 mg/mL (314.34 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1434 mL 15.7168 mL 31.4337 mL
    5 mM 0.6287 mL 3.1434 mL 6.2867 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.86%

    COA (251 KB) HNMR (264 KB) LCMS (129 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 3.1434 mL 15.7168 mL 31.4337 mL 78.5842 mL
    5 mM 0.6287 mL 3.1434 mL 6.2867 mL 15.7168 mL
    10 mM 0.3143 mL 1.5717 mL 3.1434 mL 7.8584 mL
    15 mM 0.2096 mL 1.0478 mL 2.0956 mL 5.2389 mL
    20 mM 0.1572 mL 0.7858 mL 1.5717 mL 3.9292 mL
    25 mM 0.1257 mL 0.6287 mL 1.2573 mL 3.1434 mL
    30 mM 0.1048 mL 0.5239 mL 1.0478 mL 2.6195 mL
    40 mM 0.0786 mL 0.3929 mL 0.7858 mL 1.9646 mL
    50 mM 0.0629 mL 0.3143 mL 0.6287 mL 1.5717 mL
    60 mM 0.0524 mL 0.2619 mL 0.5239 mL 1.3097 mL
    80 mM 0.0393 mL 0.1965 mL 0.3929 mL 0.9823 mL
    100 mM 0.0314 mL 0.1572 mL 0.3143 mL 0.7858 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Meclofenamic acid sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Meclofenamic acid6385-02-0MeclofenamateGap Junction ProteinEndogenous MetaboliteFat Mass and Obesity-associated Protein (FTO)Anti-inflammatoryAntitumorPC9H292haSMCsProstate tumorInhibitorinhibitorinhibit

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