TRAPPC6A - trafficking protein particle complex subunit 6A Gene

Homo sapiens

Also known as TRS33

Gene ID: 79090 | Gene type: protein coding

About TRAPPC6A

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,162,933-45,178,237 (from NCBI)

Ubiquitous expression in kidney (RPKM 18.2), spleen (RPKM 12.2) and 25 other tissues.

Summary

This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

TRAPPC6A Products(4)

mRNA	Protein	Name
NM_001270891.2	NP_001257820.1	trafficking protein particle complex subunit 6A isoform 2
NM_001270892.2	NP_001257821.1	trafficking protein particle complex subunit 6A isoform 3
NM_001270893.2	NP_001257822.1	trafficking protein particle complex subunit 6A isoform 4
NM_024108.3	NP_077013.1	trafficking protein particle complex subunit 6A isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAPPC6A Protein Structure

TRAPP

0
100
159 a.a.

Protein Preferred Names

Protein Names

trafficking protein particle complex subunit 6A

TRAPP complex subunit 6A

TRAPPC6A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Y2H Array	25416956
Intra	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Y2H Prey Pooling	25416956
Intra	TRAPPC6A	O75865	HEL-S-101	Homo sapiens	V9HW27	Validated Y2H	25416956
Intra	TRAPPC6A	O75865	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Array	25416956
Intra	TRAPPC6A	O75865	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Prey Pooling	25416956
Cross	TRAPPC6A	O75865	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Cross	TRAPPC6A	O75865	Hoxa1	Mus musculus	P09022	Y2H	23088713
Intra	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Prey Pooling	25416956
Intra	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Pull Down	16828797
Intra	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Array	31515488
Intra	TRAPPC6A	O75865	TRAPPC3	Homo sapiens	O43617	Y2H Array	25416956
Intra	TRAPPC6A	O75865	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda	X-Linked Spondyloepiphyseal Dysplasia Tarda
SEDT	Sed Tarda, X-Linked
Spondyloepiphyseal Dysplasia, Late	Spondyloepiphyseal Dysplasia Tarda X-Linked
Sed	X Linked Spondyloepiphyseal Dysplasia Tarda
X-Linked Spondyloepiphyseal Dysplasia	Late Onset Spondyloepiphyseal Dysplasia
Sed Tarda	X-Linked Sed
X-Linked Sedt	Dysplasia, Spondyloepiphyseal, Tarda
Spondyloepiphyseal Dysplasia

Developmental And Epileptic Encephalopathy 84

DEE84	Jamuar Syndrome
Eiee84	Developmental And Epileptic Encephalopathy, 84
Epileptic Encephalopathy, Early Ifantile, 84	Early Infantile Epileptic Encephalopathy 84
Epileptic Encephalopathy, Early Infantile, 84	Encephalopathy, Epileptic, Early Infantile, Type 84

Developmental And Epileptic Encephalopathy 28

DEE28	Epileptic Encephalopathy, Early Infantile, 28
Eiee28	Developmental And Epileptic Encephalopathy, 28
Early Infantile Epileptic Encephalopathy 28	Encephalopathy, Epileptic, Early Infantile, Type 28

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14993	TRAPPC6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRAPPC6A	VGNC	VGNC:36292
Felis catus	TRAPPC6A	VGNC	VGNC:66514
Macaca mulatta	TRAPPC6A	VGNC	VGNC:79374
Mus musculus	TRAPPC6A	MGD	MGI:1914341
Canis familiaris	TRAPPC6A	VGNC	VGNC:47785
Rattus norvegicus	TRAPPC6A	RGD	RGD:1591735

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