NELFE - negative elongation factor complex member E Gene

Homo sapiens

Also known as RD; RDP; RDBP; D6S45; NELF-E

Gene ID: 7936 | Gene type: protein coding

About NELFE

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,952,087-31,958,971 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 193 orthologues. Ubiquitous expression in testis (RPKM 52.1), ovary (RPKM 20.1) and 25 other tissues.

Summary

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]

NELFE Products(1)

mRNA	Protein	Name
NM_002904.6	NP_002895.3	negative elongation factor E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	27256882	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	14701750	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	27256882	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12612062	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	12612062	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NELF complex	IDA IDA: Inferred from direct assay	12612062	GOA
part of NELF complex	IPI IPI: Inferred from physical interaction	12612062	GOA
located in chromatin	IDA IDA: Inferred from direct assay	14701750	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	27256882	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12612062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NELFE Protein Structure

RRM_1

0
100
200
300
380 a.a.

Protein Preferred Names

Protein Names

negative elongation factor E

RD RNA-binding protein

NELFE Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92-2	Y2H Prey Pooling	32296183
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92-2	Y2H Array	32296183
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92-2	Validated Y2H	32296183
Intra	NELFE	P18615	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	NELFE	P18615	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	NELFE	P18615	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	NELFE	P18615	CCDC57	Homo sapiens	Q2TAC2	Y2H Prey Pooling	25416956
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92	Anti Tag CoIP	12612062
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92	Y2H Array	20211142
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92	Anti Tag CoIP	26496610
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92	Anti Tag CoIP	33961781
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92	Y2H	14667819
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92	Anti Tag CoIP	28514442
Intra	NELFE	P18615	NELFB	Homo sapiens	Q8WX92	TAP	24981860
Intra	NELFE	P18615	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	NELFE	P18615	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	NELFE	P18615	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

NELFE Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81620	NELFE Antibody (YA1365)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Immunodeficiency 12

Combined Immunodeficiency Due To Malt1 Deficiency	IMD12
Immunodeficiency, Type 12

Hairy Tongue

Overgrowth Of Filiform Papillae

Tongue, Hairy

Benign Pleural Mesothelioma

Mesothelioma Of Pleura	Benign Neoplasm Of Mesothelial Tissue Of Pleura
Pleural Malignant Mesothelioma

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09203	NELFE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NELFE	RGD	RGD:1303325
Macaca mulatta	NELFE	VGNC	VGNC:83437
Bos taurus	NELFE	VGNC	VGNC:32002
Felis catus	NELFE	VGNC	VGNC:63774
Mus musculus	NELFE	MGD	MGI:102744

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