FYCO1 - FYVE and coiled-coil domain autophagy adaptor 1 Gene

Homo sapiens

Also known as CATC2; RUFY3; ZFYVE7; CTRCT18

Gene ID: 79443 | Gene type: protein coding

About FYCO1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,917,903-45,995,824 (from NCBI)

This gene has 5 transcripts (splice variants), 286 orthologues, 1 paralogue and is associated with 5 phenotypes. Ubiquitous expression in heart (RPKM 22.7), endometrium (RPKM 12.6) and 25 other tissues.

Summary

The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the Kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020]

FYCO1 Products(11)

mRNA	Protein	Name
NM_001386421.1	NP_001373350.1	FYVE and coiled-coil domain-containing protein 1 isoform 1
NM_001386422.1	NP_001373351.1	FYVE and coiled-coil domain-containing protein 1 isoform 1
NM_001386423.1	NP_001373352.1	FYVE and coiled-coil domain-containing protein 1 isoform 2
NM_001386424.1	NP_001373353.1	FYVE and coiled-coil domain-containing protein 1 isoform 3
NM_001386425.1	NP_001373354.1	FYVE and coiled-coil domain-containing protein 1 isoform 4
NM_001386426.1	NP_001373355.1	FYVE and coiled-coil domain-containing protein 1 isoform 5
NM_001386427.1	NP_001373356.1	FYVE and coiled-coil domain-containing protein 1 isoform 6
NM_001386428.1	NP_001373357.1	FYVE and coiled-coil domain-containing protein 1 isoform 7
NM_001386429.1	NP_001373358.1	FYVE and coiled-coil domain-containing protein 1 isoform 8
NM_001386430.1	NP_001373359.1	FYVE and coiled-coil domain-containing protein 1 isoform 9
NM_024513.4	NP_078789.2	FYVE and coiled-coil domain-containing protein 1 isoform 1

FYCO1 Protein Structure

RUN

FYVE

0
300
600
900
1200
1478 a.a.

Protein Preferred Names

Protein Names

FYVE and coiled-coil domain-containing protein 1

FYVE and coiled-coil domain containing 1

FYCO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	FYCO1	Q9BQS8	P0DTD1-PRO_0000449630	SARS-CoV-2	P0DTD1-PRO_0000449630	Y2H Array	36217030
Intra	FYCO1	Q9BQS8	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	FYCO1	Q9BQS8	KIF5B	Homo sapiens	P33176	Pull Down	25855459
Intra	FYCO1	Q9BQS8	KIF5B	Homo sapiens	P33176	Anti Tag CoIP	25855459
Intra	FYCO1	Q9BQS8	KIF5B	Homo sapiens	P33176	Anti Tag CoIP	20562859
Intra	FYCO1	Q9BQS8	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	FYCO1	Q9BQS8	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	FYCO1	Q9BQS8	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	FYCO1	Q9BQS8	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	FYCO1	Q9BQS8	KLC2	Homo sapiens	Q9H0B6	Pull Down	25855459
Intra	FYCO1	Q9BQS8	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	FYCO1	Q9BQS8	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924
Intra	FYCO1	Q9BQS8	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cataract 18

Cataract, Autosomal Recessive Congenital 2	Catc2
CTRCT18	Autosomal Recessive Congenital Cataract 2
Cataract 18, Autosomal Recessive	Cataract 18 Autosomal Recessive
Cataract, Type 18

Cataract 44

CTRCT44	Total Early-Onset Cataract
Cataract 44 And Hypotrichosis	Cataract And Hypotrichosis
Cataract, Type 44

Early-Onset Nuclear Cataract

Inclusion Body Myositis

Ibm	Sporadic Inclusion Body Myositis
Inflammatory Myopathy	Myositis, Inclusion Body
Inflammatory Myopathies	Sibm
Myositis Inclusion Body	Nonaka Myopathy
Inclusion Body Myopathy, Autosomal Recessive	Inclusion Body Myopathy, Autosomal Dominant
Myositis	Inclusion Body Myopathy, Sporadic

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Myositis

Idiopathic Inflammatory Myopathy	Idiopathic Inflammatory Myositis
Iim	Imm
Idiopathic Inflammatory Myopathies	Myopathy, Familial Idiopathic Inflammatory
Inflammatory Disorder Of Muscle	Idiopathic Inflammatory Myopathy, Familial
Inflammatory Myopathy, Idiopathic	Myopathies Idiopathic Inflammatory
Familial Idiopathic Inflammatory Myopathy

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Deprivation Amblyopia

Disuse Amblyopia

Stimulus Deprivation Amblyopia

Combined Cellular And Humoral Immune Defects With Granulomas

Combined Immunodeficiency With Skin Granulomas	CCHIDG
Cid Due To Rag 1/2 Deficiency	Combined Immunodeficiency Due To Rag 1/2 Deficiency
Combined Immunodeficiency With Granulomatosis	CHIDG
Immune Defects, Combined Cellular And Humoral With Granulomas

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05173	FYCO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FYCO1	VGNC	VGNC:72722
Felis catus	FYCO1	VGNC	VGNC:80049
Rattus norvegicus	FYCO1	RGD	RGD:1309069
Canis familiaris	FYCO1	VGNC	VGNC:41026
Bos taurus	FYCO1	VGNC	VGNC:29162
Mus musculus	FYCO1	MGD	MGI:107277

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