KIF5B - kinesin family member 5B Gene

Homo sapiens

Also known as KNS; KINH; KNS1; UKHC; HEL-S-61

Gene ID: 3799 | Gene type: protein coding

About KIF5B

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:32,009,015-32,056,425 (from NCBI)

This gene has 2 transcripts (splice variants), 290 orthologues, 41 paralogues and is associated with 71 phenotypes. Ubiquitous expression in testis (RPKM 44.1), gall bladder (RPKM 42.8) and 25 other tissues.

Summary

Enables identical protein binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including lysosome localization; natural killer cell mediated cytotoxicity; and positive regulation of protein localization to plasma membrane. Located in centriolar satellite; cytosol; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]

KIF5B Products(1)

mRNA	Protein	Name
NM_004521.3	NP_004512.1	kinesin-1 heavy chain

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17013387	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	28426968	GOA
enables microtubule motor activity	IDA IDA: Inferred from direct assay	28426968	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome localization	IMP IMP: Inferred from mutant phenotype	20386726	GOA
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	22172677	GOA
involved in natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	24088571	GOA
involved in positive regulation of potassium ion transport	IDA IDA: Inferred from direct assay	19675065	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19675065	GOA
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	19675065	GOA
involved in vesicle transport along microtubule	IDA IDA: Inferred from direct assay	28426968	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in vesicle	IDA IDA: Inferred from direct assay	20682791	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF5B Protein Structure

Kinesin

0
200
400
600
800
963 a.a.

Protein Preferred Names

Protein Names

kinesin-1 heavy chain

conventional kinesin heavy chain

Related Diseases

Diseases

Alias

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Histiocytosis

Chronic Histiocytosis X	Hand Schuller Christian Disease
Hand-Schüller-Christian Disease	Histiocytic Syndrome
Histiocytosis, Langerhans-Cell

Lung Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Neuroendocrine Carcinoma Of Lung	Pulmonary Combined Large Cell Neuroendocrine Carcinoma
Combined Large Cell Lung Neuroendocrine Carcinoma

Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe	Malignant Neoplasm Of Occipital Lobe
Tumor Of Occipital Lobe

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Spastic Paraplegia 10, Autosomal Dominant

SPG10	Hereditary Spastic Paraplegia 10
Autosomal Dominant Spastic Paraplegia Type 10	Spastic Paraplegia 10
Spastic Paraplegia 10 With Or Without Peripheral Neuropathy	Autosomal Dominant Spastic Paraplegia 10
Autosomal Dominant Spastic Paraplegia	Spastic Paraplegia, Autosomal Dominant
Paraplegia, Spastic, Autosomal Dominant, Type 10

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133551	WF-47-JS03	Inhibitor	99.63%	Unkown
HY-146710	RET-IN-16	Inhibitor	/	Unkown
HY-RS07290	KIF5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KIF5B	RGD	RGD:621559
Bos taurus	KIF5B	VGNC	VGNC:30606
Felis catus	KIF5B	VGNC	VGNC:67945
Mus musculus	KIF5B	MGD	MGI:1098268
Canis familiaris	KIF5B	VGNC	VGNC:42408
Macaca mulatta	KIF5B	VGNC	VGNC:74020

Name
Email *

	Sorry, but the email address you supplied was invalid.