2. Gene
  3. CHMP6 - charged multivesicular body protein 6 Gene

CHMP6 - charged multivesicular body protein 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as VPS20

Gene ID: 79643 | Gene type: protein coding

About CHMP6

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,991,841-81,000,133 (from NCBI)

This gene has 4 transcripts (splice variants) and 259 orthologues. Ubiquitous expression in kidney (RPKM 3.0), colon (RPKM 3.0) and 25 other tissues.

Summary

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]

CHMP6 Products(1)

mRNA Protein Name
NM_024591.5 NP_078867.2 charged multivesicular body protein 6
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14505570 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16973552 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome maturation IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in autophagy IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in late endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in midbody abscission IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in multivesicular body sorting pathway IDA
IDA: Inferred from direct assay
16554368 GOA
involved in negative regulation of epidermal growth factor-activated receptor activity IMP
IMP: Inferred from mutant phenotype
16973552 GOA
involved in nuclear membrane reassembly IMP
IMP: Inferred from mutant phenotype
26040713 GOA
involved in nucleus organization IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in plasma membrane repair IDA
IDA: Inferred from direct assay
24482116 GOA
NOT involved in regulation of exosomal secretion IMP
IMP: Inferred from mutant phenotype
22660413 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
18606141 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
IDA: Inferred from direct assay
17984323 GOA
involved in viral budding from plasma membrane IDA
IDA: Inferred from direct assay
24878737 GOA
involved in viral budding via host ESCRT complex IDA
IDA: Inferred from direct assay
24878737 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ESCRT III complex IDA
IDA: Inferred from direct assay
24878737 GOA
located in amphisome membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in autophagosome membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
16973552 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
26040712 GOA
located in kinetochore microtubule IDA
IDA: Inferred from direct assay
26040712 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in midbody IDA
IDA: Inferred from direct assay
26040712 GOA
located in multivesicular body membrane IDA
IDA: Inferred from direct assay
16554368 GOA
part of nuclear pore IDA
IDA: Inferred from direct assay
26040713 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
24878737 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP6 Protein Structure

Snf7

Snf7: Snf7 (18 - 177)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

charged multivesicular body protein 6

chromatin-modifying protein 6

CHMP6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CHMP6 Q96FZ7 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
CHMP6 Q96FZ7 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
CHMP6 Q96FZ7 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
CHMP6 Q96FZ7 TOR1A Homo sapiens O14656-2
Y2H Array
32814053
Intra
CHMP6 Q96FZ7 TOR1A Homo sapiens O14656-2
Y2H Pooling
32814053
Intra
CHMP6 Q96FZ7 TOR1A Homo sapiens O14656-2
Validated Y2H
32814053
Intra
CHMP6 Q96FZ7 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
Intra
CHMP6 Q96FZ7 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
Intra
CHMP6 Q96FZ7 SMN1 Homo sapiens Q16637
Y2H Array
32814053
Intra
CHMP6 Q96FZ7 VPS25 Homo sapiens Q9BRG1
Validated Y2H
32296183
Intra
CHMP6 Q96FZ7 VPS25 Homo sapiens Q9BRG1
Anti Tag CoIP
33961781
Intra
CHMP6 Q96FZ7 VPS25 Homo sapiens Q9BRG1
Pull Down
16856878
Cross: Cross-species interaction Intra: Intraspecies interaction

CHMP6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83695 CHMP6 Antibody WB, IHC-P Human, Mouse
HY-P83696 Cytochrome P450 4A/CYP4A11 Antibody (YA3431) WB, IHC-P, IP Human, Mouse, Rat

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02647 CHMP6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CHMP6 MGD MGI:3583942
Rattus norvegicus CHMP6 RGD RGD:1565325
Canis familiaris CHMP6 VGNC VGNC:51941
Felis catus CHMP6 VGNC VGNC:98880
Bos taurus CHMP6 VGNC VGNC:27305
Macaca mulatta CHMP6 VGNC VGNC:71100
Others CHMP6 NCBI