2. Gene
  3. VPS25 - vacuolar protein sorting 25 homolog Gene

VPS25 - vacuolar protein sorting 25 homolog Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DERP9; EAP20; FAP20

Gene ID: 84313 | Gene type: protein coding

About VPS25

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,773,449-42,779,599 (from NCBI)

This gene has 6 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in esophagus (RPKM 14.2), colon (RPKM 12.6) and 25 other tissues.

Summary

This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]

VPS25 Products(1)

mRNA Protein Name
NM_032353.4 NP_115729.1 vacuolar protein-sorting-associated protein 25
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14505570 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
14519844 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of epidermal growth factor-activated receptor activity IMP
IMP: Inferred from mutant phenotype
16973552 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ESCRT II complex IDA
IDA: Inferred from direct assay
16973552 GOA
part of ESCRT II complex IPI
IPI: Inferred from physical interaction
18539118 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16973552 GOA
located in cytosol IDA
IDA: Inferred from direct assay
17010938 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
16371348 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16371348 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS25 Protein Structure

ESCRT-II

ESCRT-II: ESCRT-II complex subunit (9 - 146)

  • 0
  • 100
  • 176 a.a.
Protein Preferred Names Protein Names

vacuolar protein-sorting-associated protein 25

ELL-associated protein of 20 kDa

VPS25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra VPS25 Q9BRG1 CHMP6 Homo sapiens Q96FZ7
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 CHMP6 Homo sapiens Q96FZ7
Y2H
16730941
Intra VPS25 Q9BRG1 CHMP6 Homo sapiens Q96FZ7
Y2H Array
32296183
Intra VPS25 Q9BRG1 ASPG Homo sapiens Q86U10
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 ASPG Homo sapiens Q86U10
Y2H Array
32296183
Intra VPS25 Q9BRG1 SEPTIN14 Homo sapiens Q6ZU15
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 SEPTIN14 Homo sapiens Q6ZU15
Y2H Array
32296183
Intra VPS25 Q9BRG1 CRLF3 Homo sapiens Q8IUI8
Y2H Prey Pooling
25416956
Intra VPS25 Q9BRG1 CRLF3 Homo sapiens Q8IUI8
Validated Y2H
25416956
Intra VPS25 Q9BRG1 CRLF3 Homo sapiens Q8IUI8
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 CRLF3 Homo sapiens Q8IUI8
Y2H Array
32296183
Intra VPS25 Q9BRG1 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra VPS25 Q9BRG1 VPS36 Homo sapiens Q86VN1
Anti Tag CoIP
33961781
Intra VPS25 Q9BRG1 VPS36 Homo sapiens Q86VN1
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 VPS36 Homo sapiens Q86VN1
Y2H Array
32296183
Intra VPS25 Q9BRG1 VPS36 Homo sapiens Q86VN1
Anti Tag CoIP
35271311
Intra VPS25 Q9BRG1 SYCE1 Homo sapiens Q8N0S2
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 SYCE1 Homo sapiens Q8N0S2
Y2H Array
32296183
Intra VPS25 Q9BRG1 B9D2 Homo sapiens Q9BPU9
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 B9D2 Homo sapiens Q9BPU9
Y2H Array
32296183
Intra VPS25 Q9BRG1 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra VPS25 Q9BRG1 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra VPS25 Q9BRG1 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra VPS25 Q9BRG1 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 BEND5 Homo sapiens Q7L4P6
Validated Y2H
25416956
Intra VPS25 Q9BRG1 TADA2A Homo sapiens O75478
Y2H Array
32296183
Intra VPS25 Q9BRG1 TADA2A Homo sapiens O75478
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
Intra VPS25 Q9BRG1 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
Intra VPS25 Q9BRG1 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra VPS25 Q9BRG1 SPG21 Homo sapiens Q9NZD8
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 SPG21 Homo sapiens Q9NZD8
Y2H Array
32296183
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Anti Tag CoIP
35271311
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Y2H
21516116
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Y2H Array
31515488
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Y2H Prey Pooling
25416956
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Validated Y2H
25416956
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Y2H Array
32296183
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Y2H Array
25416956
Intra VPS25 Q9BRG1 SNF8 Homo sapiens Q96H20
Anti Tag CoIP
33961781
Intra VPS25 Q9BRG1 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra VPS25 Q9BRG1 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra VPS25 Q9BRG1 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra VPS25 Q9BRG1 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra VPS25 Q9BRG1 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Intra VPS25 Q9BRG1 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7

Ftd3

Frontotemporal Dementia, Chromosome 3-Linked

Amyotrophic Lateral Sclerosis, Chmp2b-Related

Chromosome 3-Linked Frontotemporal Dementia

FTDALS7

Chmp2b-Related Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 17, Formerly

Als17, Formerly

Amyotrophic Lateral Sclerosis Type 17

Dtm1

Ftd-3

Ftd-Chmp2b

Als17

Amyotrophic Lateral Sclerosis 17

Sclerosis, Lateral, Amyotrophic, Type 17

Dementia, Frontotemporal, Chromosome 3-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15678 VPS25 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VPS25 MGD MGI:106354
Felis catus VPS25 VGNC VGNC:99572
Bos taurus VPS25 VGNC VGNC:36813
Macaca mulatta VPS25 VGNC VGNC:79685
Rattus norvegicus VPS25 RGD RGD:1584685