FASTKD1 - FAST kinase domains 1 Gene

Homo sapiens

Gene ID: 79675 | Gene type: protein coding

About FASTKD1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:169,528,508-169,573,865 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in heart (RPKM 4.3), duodenum (RPKM 3.9) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mitochondrial RNA metabolic process and regulation of mitochondrial mRNA stability. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

FASTKD1 Products(5)

mRNA	Protein	Name
NM_001281476.3	NP_001268405.1	FAST kinase domain-containing protein 1, mitochondrial isoform 2
NM_001322046.2	NP_001308975.1	FAST kinase domain-containing protein 1, mitochondrial isoform 1
NM_001322048.2	NP_001308977.1	FAST kinase domain-containing protein 1, mitochondrial isoform 3
NM_001322049.2	NP_001308978.1	FAST kinase domain-containing protein 1, mitochondrial isoform 4
NM_024622.6	NP_078898.3	FAST kinase domain-containing protein 1, mitochondrial isoform 1

FASTKD1 Protein Structure

FAST_1

FAST_2

RAP

0
200
400
600
800
847 a.a.

Protein Preferred Names

Protein Names

FAST kinase domain-containing protein 1, mitochondrial

FASTKD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FASTKD1	Q53R41	EIF2S3	Homo sapiens	P41091	Y2H Array	32814053
Intra	FASTKD1	Q53R41	EIF2S3	Homo sapiens	P41091	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	EIF2S3	Homo sapiens	P41091	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	FASTKD1	Q53R41	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	FASTKD1	Q53R41	ST13	Homo sapiens	Q9P1I4	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	ST13	Homo sapiens	Q9P1I4	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	ST13	Homo sapiens	Q9P1I4	Y2H Array	32814053
Intra	FASTKD1	Q53R41	HSPA2	Homo sapiens	P54652	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	HSPA2	Homo sapiens	P54652	Y2H Array	32814053
Intra	FASTKD1	Q53R41	HSPA2	Homo sapiens	P54652	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	P4HB	Homo sapiens	P07237	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	P4HB	Homo sapiens	P07237	Y2H Array	32814053
Intra	FASTKD1	Q53R41	P4HB	Homo sapiens	P07237	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	FASTKD1	Q53R41	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	FASTKD1	Q53R41	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	FASTKD1	Q53R41	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	FASTKD1	Q53R41	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	FASTKD1	Q53R41	GRN	Homo sapiens	P28799	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glaucoma 1, Open Angle, B

GLC1B

Glaucoma 1b, Primary Open Angle, Adult Onset

Mitochondrial Encephalomyopathy

Mitochondrial Encephalomyopathies

Encephalomyopathy, Mitochondrial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04757	FASTKD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FASTKD1	VGNC	VGNC:28873
Rattus norvegicus	FASTKD1	RGD	RGD:1563531
Canis familiaris	FASTKD1	VGNC	VGNC:40738
Felis catus	FASTKD1	VGNC	VGNC:62154
Mus musculus	FASTKD1	MGD	MGI:2444596
Macaca mulatta	FASTKD1	VGNC	VGNC:72580

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