HSPA2 - heat shock protein family A (Hsp70) member 2 Gene

Homo sapiens

Also known as HSP70-2; HSP70-3

Gene ID: 3306 | Gene type: protein coding

About HSPA2

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,535,905-64,543,237 (from NCBI)

This gene has 3 transcripts (splice variants), 334 orthologues and 13 paralogues.

Summary

Enables disordered domain specific binding activity; Enzyme binding activity; and unfolded protein binding activity. Involved in negative regulation of inclusion body assembly and protein refolding. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

HSPA2 Products(2)

mRNA	Protein	Name
NM_001387931.1	NP_001374860.1	heat shock-related 70 kDa protein 2
NM_021979.4	NP_068814.2	heat shock-related 70 kDa protein 2

HSPA2 Protein Structure

HSP70

0
100
200
300
400
500
600
639 a.a.

Protein Preferred Names

Protein Names

heat shock-related 70 kDa protein 2

epididymis secretory sperm binding protein

HSPA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPA2	P54652	WBP1L	Homo sapiens	Q9NX94	Y2H Pooling	32814053
Intra	HSPA2	P54652	WBP1L	Homo sapiens	Q9NX94	Validated Y2H	32814053
Intra	HSPA2	P54652	WBP1L	Homo sapiens	Q9NX94	Y2H Array	32814053
Intra	HSPA2	P54652	LARP4B	Homo sapiens	Q92615	Y2H Pooling	32814053
Intra	HSPA2	P54652	LARP4B	Homo sapiens	Q92615	Validated Y2H	32814053
Intra	HSPA2	P54652	LARP4B	Homo sapiens	Q92615	Y2H Array	32814053
Intra	HSPA2	P54652	SPATA12	Homo sapiens	Q7Z6I5	Validated Y2H	32814053
Intra	HSPA2	P54652	SPATA12	Homo sapiens	Q7Z6I5	Y2H Array	32814053
Intra	HSPA2	P54652	SPATA12	Homo sapiens	Q7Z6I5	Y2H Pooling	32814053
Intra	HSPA2	P54652	DNAJA3	Homo sapiens	Q96EY1-3	Y2H Pooling	32814053
Intra	HSPA2	P54652	DNAJA3	Homo sapiens	Q96EY1-3	Validated Y2H	32814053
Intra	HSPA2	P54652	DNAJA3	Homo sapiens	Q96EY1-3	Y2H Array	32814053
Intra	HSPA2	P54652	CD209	Homo sapiens	Q9NNX6-10	Validated Y2H	32814053
Intra	HSPA2	P54652	CD209	Homo sapiens	Q9NNX6-10	Y2H Array	32814053
Intra	HSPA2	P54652	CD209	Homo sapiens	Q9NNX6-10	Y2H Pooling	32814053
Intra	HSPA2	P54652	ZNF341	Homo sapiens	Q9BYN7-2	Validated Y2H	32814053
Intra	HSPA2	P54652	ZNF341	Homo sapiens	Q9BYN7-2	Y2H Pooling	32814053
Intra	HSPA2	P54652	ZNF341	Homo sapiens	Q9BYN7-2	Y2H Array	32814053
Intra	HSPA2	P54652	SERTAD4	Homo sapiens	Q9NUC0	Validated Y2H	32814053
Intra	HSPA2	P54652	SERTAD4	Homo sapiens	Q9NUC0	Y2H Array	32814053
Intra	HSPA2	P54652	SERTAD4	Homo sapiens	Q9NUC0	Y2H Pooling	32814053
Intra	HSPA2	P54652	ZNF829	Homo sapiens	Q3KNS6-3	Y2H Array	32814053
Intra	HSPA2	P54652	ZNF829	Homo sapiens	Q3KNS6-3	Y2H Pooling	32814053
Intra	HSPA2	P54652	ZNF829	Homo sapiens	Q3KNS6-3	Validated Y2H	32814053
Intra	HSPA2	P54652	ZKSCAN3	Homo sapiens	Q9BRR0	Validated Y2H	32814053
Intra	HSPA2	P54652	ZKSCAN3	Homo sapiens	Q9BRR0	Y2H Array	32814053
Intra	HSPA2	P54652	ZKSCAN3	Homo sapiens	Q9BRR0	Y2H Pooling	32814053
Intra	HSPA2	P54652	TRIM38	Homo sapiens	O00635	Y2H Array	25416956
Intra	HSPA2	P54652	PLEKHG4	Homo sapiens	Q58EX7-2	Y2H Array	32814053
Intra	HSPA2	P54652	PLEKHG4	Homo sapiens	Q58EX7-2	Validated Y2H	32814053
Intra	HSPA2	P54652	PLEKHG4	Homo sapiens	Q58EX7-2	Y2H Pooling	32814053
Intra	HSPA2	P54652	UBE2A	Homo sapiens	P49459	Validated Y2H	32814053
Intra	HSPA2	P54652	UBE2A	Homo sapiens	P49459	Y2H Pooling	32814053
Intra	HSPA2	P54652	UBE2A	Homo sapiens	P49459	Y2H Array	32814053
Intra	HSPA2	P54652	DPF1	Homo sapiens	Q92782-2	Validated Y2H	32814053
Intra	HSPA2	P54652	DPF1	Homo sapiens	Q92782-2	Y2H Array	32814053
Intra	HSPA2	P54652	DPF1	Homo sapiens	Q92782-2	Y2H Pooling	32814053
Intra	HSPA2	P54652	ZNF124	Homo sapiens	Q15973	Y2H Pooling	32814053
Intra	HSPA2	P54652	ZNF124	Homo sapiens	Q15973	Validated Y2H	32814053
Intra	HSPA2	P54652	ZNF124	Homo sapiens	Q15973	Y2H Array	32814053
Intra	HSPA2	P54652	HSF2	Homo sapiens	Q03933	Lumier	25036637
Intra	HSPA2	P54652	OTUD7B	Homo sapiens	Q6GQQ9-2	Validated Y2H	32814053
Intra	HSPA2	P54652	OTUD7B	Homo sapiens	Q6GQQ9-2	Y2H Array	32814053
Intra	HSPA2	P54652	OTUD7B	Homo sapiens	Q6GQQ9-2	Y2H Pooling	32814053
Intra	HSPA2	P54652	TMEM61	Homo sapiens	Q8N0U2	Y2H Pooling	32814053
Intra	HSPA2	P54652	TMEM61	Homo sapiens	Q8N0U2	Validated Y2H	32814053
Intra	HSPA2	P54652	TMEM61	Homo sapiens	Q8N0U2	Y2H Array	32814053
Intra	HSPA2	P54652	PRR3	Homo sapiens	P79522	Validated Y2H	32814053
Intra	HSPA2	P54652	PRR3	Homo sapiens	P79522	Y2H Array	32814053
Intra	HSPA2	P54652	PRR3	Homo sapiens	P79522	Y2H Pooling	32814053
Intra	HSPA2	P54652	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	HSPA2	P54652	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	HSPA2	P54652	HSPBP1	Homo sapiens	Q9NZL4	Validated Y2H	25416956
Intra	HSPA2	P54652	HSPBP1	Homo sapiens	Q9NZL4	Y2H Array	16713569
Intra	HSPA2	P54652	HSPBP1	Homo sapiens	Q9NZL4	Y2H Pooling	16189514
Intra	HSPA2	P54652	SSB	Homo sapiens	P05455	Validated Y2H	32814053
Intra	HSPA2	P54652	SSB	Homo sapiens	P05455	Y2H Array	32814053
Intra	HSPA2	P54652	SSB	Homo sapiens	P05455	Y2H Pooling	32814053
Intra	HSPA2	P54652	NEUROD1	Homo sapiens	Q13562	Validated Y2H	32814053
Intra	HSPA2	P54652	NEUROD1	Homo sapiens	Q13562	Y2H Array	32814053
Intra	HSPA2	P54652	NEUROD1	Homo sapiens	Q13562	Y2H Pooling	32814053
Intra	HSPA2	P54652	FGF21	Homo sapiens	Q9NSA1	Validated Y2H	32814053
Intra	HSPA2	P54652	FGF21	Homo sapiens	Q9NSA1	Y2H Array	32814053
Intra	HSPA2	P54652	FGF21	Homo sapiens	Q9NSA1	Y2H Pooling	32814053
Intra	HSPA2	P54652	FGF21	Homo sapiens	Q9NSA1	Lumier	32814053
Intra	HSPA2	P54652	TSPAN2	Homo sapiens	O60636	Y2H Array	32814053
Intra	HSPA2	P54652	TSPAN2	Homo sapiens	O60636	Y2H Pooling	32814053
Intra	HSPA2	P54652	TSPAN2	Homo sapiens	O60636	Validated Y2H	32814053
Intra	HSPA2	P54652	SPATS1	Homo sapiens	Q496A3	Y2H Pooling	32814053
Intra	HSPA2	P54652	SPATS1	Homo sapiens	Q496A3	Validated Y2H	32814053
Intra	HSPA2	P54652	SPATS1	Homo sapiens	Q496A3	Y2H Array	32814053
Intra	HSPA2	P54652	SOCS6	Homo sapiens	O14544	Validated Y2H	32814053
Intra	HSPA2	P54652	SOCS6	Homo sapiens	O14544	Y2H Pooling	32814053
Intra	HSPA2	P54652	SOCS6	Homo sapiens	O14544	Y2H Array	32814053
Intra	HSPA2	P54652	MAP3K5	Homo sapiens	Q99683	Y2H Array	32814053
Intra	HSPA2	P54652	MAP3K5	Homo sapiens	Q99683	Y2H Pooling	32814053
Intra	HSPA2	P54652	MAP3K5	Homo sapiens	Q99683	Validated Y2H	32814053
Intra	HSPA2	P54652	ARL6IP4	Homo sapiens	Q66PJ3-4	Validated Y2H	32814053
Intra	HSPA2	P54652	ARL6IP4	Homo sapiens	Q66PJ3-4	Y2H Array	32814053
Intra	HSPA2	P54652	ARL6IP4	Homo sapiens	Q66PJ3-4	Y2H Pooling	32814053
Intra	HSPA2	P54652	ASH2L	Homo sapiens	Q9UBL3	Y2H Pooling	32814053
Intra	HSPA2	P54652	ASH2L	Homo sapiens	Q9UBL3	Validated Y2H	32814053
Intra	HSPA2	P54652	ASH2L	Homo sapiens	Q9UBL3	Y2H Array	32814053
Intra	HSPA2	P54652	INCA1	Homo sapiens	Q0VD86	Y2H Pooling	32814053
Intra	HSPA2	P54652	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32814053
Intra	HSPA2	P54652	INCA1	Homo sapiens	Q0VD86	Y2H Array	32814053
Intra	HSPA2	P54652	POLR3F	Homo sapiens	Q9H1D9	Y2H Array	32814053
Intra	HSPA2	P54652	POLR3F	Homo sapiens	Q9H1D9	Validated Y2H	32814053
Intra	HSPA2	P54652	POLR3F	Homo sapiens	Q9H1D9	Y2H Pooling	32814053
Intra	HSPA2	P54652	POLA2	Homo sapiens	Q14181	Validated Y2H	32814053
Intra	HSPA2	P54652	POLA2	Homo sapiens	Q14181	Y2H Array	32814053
Intra	HSPA2	P54652	POLA2	Homo sapiens	Q14181	Y2H Pooling	32814053
Intra	HSPA2	P54652	BAHD1	Homo sapiens	Q8TBE0	Y2H Pooling	32814053
Intra	HSPA2	P54652	BAHD1	Homo sapiens	Q8TBE0	Validated Y2H	32814053
Intra	HSPA2	P54652	BAHD1	Homo sapiens	Q8TBE0	Y2H Array	32814053
Intra	HSPA2	P54652	FOSL1	Homo sapiens	P15407	Validated Y2H	32814053
Intra	HSPA2	P54652	FOSL1	Homo sapiens	P15407	Y2H Array	32814053
Intra	HSPA2	P54652	FOSL1	Homo sapiens	P15407	Y2H Pooling	32814053
Intra	HSPA2	P54652	ASB9	Homo sapiens	Q96DX5	Validated Y2H	32814053
Intra	HSPA2	P54652	ASB9	Homo sapiens	Q96DX5	Y2H Array	32814053
Intra	HSPA2	P54652	ASB9	Homo sapiens	Q96DX5	Y2H Pooling	32814053
Intra	HSPA2	P54652	CHMP7	Homo sapiens	Q8WUX9	Y2H Pooling	32814053
Intra	HSPA2	P54652	CHMP7	Homo sapiens	Q8WUX9	Validated Y2H	32814053
Intra	HSPA2	P54652	CHMP7	Homo sapiens	Q8WUX9	Y2H Array	32814053
Intra	HSPA2	P54652	MIP	Homo sapiens	P30301	Validated Y2H	32814053
Intra	HSPA2	P54652	MIP	Homo sapiens	P30301	Y2H Array	32814053
Intra	HSPA2	P54652	MIP	Homo sapiens	P30301	Y2H Pooling	32814053
Intra	HSPA2	P54652	AK8	Homo sapiens	Q96MA6	Y2H Array	32814053
Intra	HSPA2	P54652	AK8	Homo sapiens	Q96MA6	Y2H Pooling	32814053
Intra	HSPA2	P54652	AK8	Homo sapiens	Q96MA6	Validated Y2H	32814053
Intra	HSPA2	P54652	ZNF296	Homo sapiens	Q8WUU4	Validated Y2H	32814053
Intra	HSPA2	P54652	ZNF296	Homo sapiens	Q8WUU4	Y2H Array	32814053
Intra	HSPA2	P54652	ZNF296	Homo sapiens	Q8WUU4	Y2H Pooling	32814053
Intra	HSPA2	P54652	TAF8	Homo sapiens	Q7Z7C8-2	Y2H Pooling	32814053
Intra	HSPA2	P54652	TAF8	Homo sapiens	Q7Z7C8-2	Validated Y2H	32814053
Intra	HSPA2	P54652	TAF8	Homo sapiens	Q7Z7C8-2	Y2H Array	32814053
Intra	HSPA2	P54652	RANGRF	Homo sapiens	Q9HD47-3	Validated Y2H	32814053
Intra	HSPA2	P54652	RANGRF	Homo sapiens	Q9HD47-3	Y2H Pooling	32814053
Intra	HSPA2	P54652	RANGRF	Homo sapiens	Q9HD47-3	Y2H Array	32814053
Intra	HSPA2	P54652	PSMF1	Homo sapiens	Q92530	Validated Y2H	32814053
Intra	HSPA2	P54652	PSMF1	Homo sapiens	Q92530	Y2H Array	32814053
Intra	HSPA2	P54652	PSMF1	Homo sapiens	Q92530	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

HSPA2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83311	HspA2 Antibody (YA3056)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Visceral Leishmaniasis

Kala-Azar	Leishmaniasis, Visceral
Infection By Visceral Leishmaniasis	Leishmaniasis Visceral
Sahib Disease	Ponos
Burdwan Fever	Mard El Bicha
Sirkari Disease	Indian Visceral Leishmaniasis
Dumdum Fever	Visceral Leishmaniasis Due To Leishmania Donovani

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152153	GRP78-IN-3	Inhibitor	99.98%	Unkown
HY-RS06427	HSPA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HSPA2	VGNC	VGNC:50533
Rattus norvegicus	HSPA2	RGD	RGD:620664
Mus musculus	HSPA2	MGD	MGI:96243
Felis catus	HSPA2	VGNC	VGNC:80953

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