BTNL8 - butyrophilin like 8 Gene

Homo sapiens

Also known as BTN9.2

Gene ID: 79908 | Gene type: protein coding

About BTNL8

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,899,159-180,950,906 (from NCBI)

This gene has 11 transcripts (splice variants), 24 orthologues and 15 paralogues. Biased expression in duodenum (RPKM 27.0), small intestine (RPKM 20.3) and 3 other tissues.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

BTNL8 Products(6)

mRNA	Protein	Name
NM_001040462.3	NP_001035552.1	butyrophilin-like protein 8 isoform 2 precursor
NM_001159707.2	NP_001153179.1	butyrophilin-like protein 8 isoform 3 precursor
NM_001159708.2	NP_001153180.1	butyrophilin-like protein 8 isoform 4 precursor
NM_001159709.2	NP_001153181.1	butyrophilin-like protein 8 isoform 5
NM_001159710.2	NP_001153182.1	butyrophilin-like protein 8 isoform 6
NM_024850.3	NP_079126.1	butyrophilin-like protein 8 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTNL8 Protein Structure

V-set

PRY

SPRY

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

butyrophilin-like protein 8

B7-H5 costimulatory molecule

BTNL8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BTNL8	Q6UX41	BTNL3	Homo sapiens	Q6UXE8	Anti Tag CoIP	29339503
Intra	BTNL8	Q6UX41	TFF1	Homo sapiens	P04155	Protein Array	21982860
Intra	BTNL8	Q6UX41	TFF1	Homo sapiens	P04155	SPR	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTNL8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79382	BTNL8 Protein, Human (HEK293, hFc)	Q6UX41-1 (Q18-K238)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01678	BTNL8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BTNL8	VGNC	VGNC:110483
Rattus norvegicus	BTNL8	RGD	RGD:1587504
Others	BTNL8	NCBI

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