1. Gene
  2. CALD1 - caldesmon 1 Gene

CALD1 - caldesmon 1 Gene

Homo sapiens

Also known as CDM; HCAD; LCAD; h-CD; H-CAD; L-CAD; NAG22

Gene ID: 800 | Gene type: protein coding

About CALD1

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,745,467-134,970,729 (from NCBI)

This gene has 24 transcripts (splice variants), 236 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 170.6), prostate (RPKM 164.0) and 23 other tissues.

Summary

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to CA(2+)-calmodulin, actin, tropomyosin, Myosin, and Phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated Myosin MgATPase, and serves as a mediating factor for CA(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CALD1 Products(5)

mRNA Protein Name
NM_004342.7 NP_004333.1 caldesmon isoform 2
NM_033138.4 NP_149129.2 caldesmon isoform 1
NM_033139.4 NP_149130.1 caldesmon isoform 4
NM_033140.4 NP_149131.1 caldesmon isoform 5
NM_033157.4 NP_149347.2 caldesmon isoform 3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALD1 Protein Structure

Caldesmon

Caldesmon: Caldesmon (31 - 362)

Caldesmon

Caldesmon: Caldesmon (405 - 781)

  • 0
  • 200
  • 400
  • 600
  • 793 a.a.
Protein Preferred Names Protein Names

caldesmon

testis secretory sperm-binding protein Li 227n

CALD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CALD1 Q05682 SPTAN1 Homo sapiens Q13813 35271311
Intra
CALD1 Q05682 SPTAN1 Homo sapiens Q13813 30021884
Intra
CALD1 Q05682 TINF2 Homo sapiens Q9BSI4 21044950
Intra
CALD1 Q05682 TINF2 Homo sapiens Q9BSI4 21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

CALD1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81556 Caldesmon/CDM Antibody (YA1301) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P82587 Caldesmon Antibody (YA2332) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Adenomyoma
Cellular Leiomyoma
Angiomyoma

Vascular Leiomyoma

Cutaneous Leiomyosarcoma

Leiomyosarcoma Of The Skin

Glomangiomatosis
Peritoneal Benign Neoplasm
Vulvar Leiomyoma
Diffuse Peritoneal Leiomyomatosis

Disseminated Peritoneal Leiomyomatosis

Leiomyomatosis Peritonealis Disseminata

Dpl

Lpd

Leiomyomatosis Peritonealis Disseminate

Conventional Leiomyosarcoma
Vulvar Benign Neoplasm
Vulvar Leiomyosarcoma
Vulvar Sarcoma

Sarcoma Of Vulva

Vulva Sarcoma

Bartholin'S Duct Cyst

Bartholin Duct Cyst

Bartholin'S Cyst

Cyst Of Bartholin'S Gland Duct

Cyst Of Bartholin'S Gland

Vulvovaginal Cyst

Cyst Of Bartholin Gland Duct

Pulmonary Vein Leiomyosarcoma

Leiomyosarcoma Of The Pulmonary Vein

Liver Leiomyosarcoma

Leiomyosarcoma Of The Liver

Glomangiomyoma
Benign Perivascular Tumor

Benign Pericytic Neoplasm

Vaginal Endometrial Stromal Tumor
Central Nervous System Leiomyosarcoma

Leiomyosarcoma Of The Cns

Fallopian Tube Leiomyoma
Urethra Leiomyoma

Leiomyoma Of The Urethra

Urethral Leiomyoma

Gallbladder Leiomyosarcoma

Leiomyosarcoma Of The Gallbladder

Glomangioma
Myxoid Leiomyosarcoma

Leiomyosarcoma, Myxoid

Vagina Leiomyosarcoma

Leiomyosarcoma Of The Vagina

Vaginal Leiomyosarcoma

Vagina Leiomyoma

Leiomyoma Of Vagina

Breast Fibrosarcoma

Fibrosarcoma Of The Breast

Bizarre Leiomyoma

Atypical Leiomyoma

Pleomorphic Leiomyoma

Symplastic Leiomyoma

Intravascular Angioleiomyoma
Glomangiosarcoma

Malignant Glomus Neoplasm

Glomus Tumor, Malignant

Atypical Polypoid Adenomyoma
Intravascular Fasciitis

Intravascular Pseudosarcomatous Fasciitis

Skin Sarcoma

Cutaneous Sarcoma

Retroperitoneal Leiomyosarcoma
Perivascular Tumor

Malignant Perivascular Cancer

Heart Leiomyosarcoma

Leiomyosarcoma Of Heart

Cardiac Leiomyosarcoma

Colon Leiomyosarcoma

Colonic Leiomyosarcoma

Breast Leiomyosarcoma

Leiomyosarcoma Of The Breast

Vagina Sarcoma

Sarcoma Of The Vagina

Vaginal Sarcoma

Breast Leiomyoma
Inflammatory Leiomyosarcoma
Testicular Fibroma
Vaginal Endometrial Stromal Sarcoma
Perivascular Epithelioid Cell Tumor

Pecoma

Perivascular Epithelioid Cell Neoplasms

Neoplasm With Perivascular Epithelioid Cell Differentiation

Myoma

Muscle Benign Neoplasm

Myomatous Neoplasm

Neoplasms, Muscle Tissue

Benign Neoplasm Of The Muscle

Muscle Neoplasm

Muscle Tissue Neoplasm

Myomatous Tumor

Neoplasm Of Muscle

Muscle Neoplasms

Myomas

Vaginal Benign Neoplasm
Subareolar Duct Papillomatosis

Adenoma Of The Nipple

Nipple Benign Neoplasm

Tumor Of Nipple

Lung Leiomyosarcoma

Pulmonary Leiomyosarcoma

Retroperitoneal Sarcoma
Small Intestine Leiomyoma

Leiomyoma, Small Bowel

Leiomyoma Of Small Intestine

Breast Myofibroblastoma
Intravenous Leiomyomatosis

Leiomyomatosis

Conventional Fibrosarcoma
Myofibroma

Lipoleiomyoma

Uterine Fibroids

Solitary Myofibromatosis

Myolipoma

Mixed Endometrial Stromal And Smooth Muscle Tumor

Stromomyoma

Mixed Endometrial Stromal And Smooth Muscle Neoplasm

Ureter Leiomyoma

Ureteral Leiomyoma

Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone

Fallopian Tube Benign Neoplasm
Kidney Leiomyosarcoma

Leiomyosarcoma Of Kidney

Epithelioid Leiomyosarcoma

Leiomyosarcoma Epithelioid

Leiomyosarcoma, Epithelioid

Subungual Glomus Tumor

Subungual Glomus Tumour

Deep Leiomyoma
Cervical Polyp

Cervix Adenomatous Polyp

Prostate Embryonal Rhabdomyosarcoma

Embryonal Rhabdomyosarcoma Of The Prostate

Endobronchial Leiomyoma
Gastric Leiomyoma

Leiomyoma Of The Stomach

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor

Mesenchymal Tumor

Mesenchymal Tumors

Lung Leiomyoma

Pulmonary Leiomyoma

Leiomyoma Of Lung

Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel

Smooth Muscle Connective Tissue Tumor

Leiomyosarcoma Of Small Intestine

Uterus Perivascular Epithelioid Cell Tumor

Uterine Corpus Pecoma

Cervical Adenoma Malignum

Cervical Mucinous Adenocarcinoma, Minimal Deviation Variant

Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors

Spindle Cell Lipoma
Muscle Cancer

Myosarcoma

Malignant Neoplasm Of Muscle

Malignant Tumor Of Muscle

Malignant Tumor Of The Muscle

Muscle Neoplasms

Myomatous Neoplasm

Esophagus Sarcoma

Esophageal Sarcoma

Pseudosarcomatous Fibromatosis

Nodular Fasciitis

Pseudosarcomatous Fasciitis

Fasciitis - Nodular

Fasciitis Nodular

Ovary Leiomyosarcoma

Leiomyosarcoma Of Ovary

Glomus Tumor

Glomus Neoplasm

Glomus Tumour

Connective Tissue Benign Neoplasm

Soft Tissue Neoplasms

Mesenchymal Tissue Neoplasm

Neoplasm Of Soft Tissue

Neoplasm Of Soft Tissues

Soft Tissue Benign Neoplasm

Tumor Of The Soft Tissue

Soft Tissue Neoplasm

Smooth Muscle Tumor
Sarcomatoid Squamous Cell Skin Carcinoma

Spindle Cell Squamous Cell Carcinoma

Spindle Cell Squamous Cell Carcinoma

Spindle Cell Squamous Cell Skin Carcinoma

Spindle Cell Squamous Carcinoma Of Skin

Squamous Cell Carcinoma, Sarcomatoid

Hemangiopericytoma, Malignant

Hemangiopericytoma

Haemangiopericytic Meningioma

Malignant Hemangiopericytoma

Solitary Fibrous Tumor

Ovarian Melanoma
Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Spindle Cell Synovial Sarcoma

Synovial Sarcoma With Spindle Cell Components

Synovial Sarcoma, Monophasic Fibrous

Synovial Sarcoma, Spindle Cell

Uterine Corpus Sarcoma

Sarcoma Of Corpus Uteri

Sarcoma Of Uterus

Sarcoma Of The Corpus Uteri

Uterine Sarcoma

Sarcoma, Nos Of Uterus

Endometrial Stromal Nodule
Sarcomatous Intrahepatic Cholangiocarcinoma

Sarcomatoid Intrahepatic Cholangiocarcinoma

Reproductive Organ Benign Neoplasm
Bone Leiomyosarcoma
Benign Peritoneal Mesothelioma

Mesothelioma Of Peritoneum

Benign Neoplasm Of Mesothelial Tissue Of Peritoneum

Infiltrating Angiolipoma

Angiolipoma, Infiltrating

Uterine Benign Neoplasm
Lung Combined Type Small Cell Carcinoma

Combined Small Cell Carcinoma Of The Lung

Combined Type Small Cell Carcinoma Of Lung

Malignant Mesenchymoma

Malignant Mesenchymal Tumor

Mesenchymoma, Malignant

Sarcoma

Rat Malignant Renal Mesenchymal Tumor

Gastric Leiomyosarcoma

Leiomyosarcoma Of Stomach

Scrotum Neoplasm

Malignant Tumour Of Scrotum

Malignant Scrotal Neoplasm

Malignant Tumor Of Scrotum

Neoplasm Of Scrotum

Scrotal Ca

Scrotal Tumor

Scrotum Cancer

Cancer Of Scrotum

Malignant Neoplasm Of Scrotum

Scrotal Cancer

Malignant Scrotal Tumour

Malignant Neoplasm Of Skin Of Scrotum

Primary Malignant Neoplasm Of Scrotum

Liver Sarcoma

Hepatic Sarcoma

Sarcoma Of Liver

Spindle Cell Rhabdomyosarcoma
Bladder Leiomyoma

Leiomyoma Of The Urinary Bladder

Vascular Cancer

Blood Vessel Tumors

Malignant Vascular Neoplasm

Renal Vein Leiomyosarcoma

Vascular Neoplasms

Blood Vessel Neoplasm

Blood Vessel Tumor

Blood Vessel Tumour Disorder

Haemangiomatous Tumour

Leiomyosarcoma Of The Renal Vein

Malignant Great Vessel Tumor

Malignant Tumor Of Pulmonary Artery

Malignant Tumor Of Pulmonary Vein

Malignant Vascular Tumor

Neoplasm Of Great Vessel

Pulmonary Artery Malignant Neoplasm

Pulmonary Vein Malignant Neoplasm

Vascular Tissue Neoplasm

Vascular Tumors

Blood Vessel Cancer

Neoplasms, Vascular Tissue

Malignant Neoplasm Of Great Vessels

Myxofibrosarcoma

Fibromyxosarcoma

Fibromyxoid Sarcoma

Myxoid Malignant Fibrous Histiocytoma

Dermatofibrosarcoma Protuberans, Myxoid

Sarcomatosis
Extraosseous Osteosarcoma

Extraskeletal Osteosarcoma

Extraskeletal Osteogenic Sarcoma

Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin

Dermis Tumor

Dermis Tumour

Neoplasm Of Dermis

Tumor Of Dermis

Tumour Of Dermis

Urethral Benign Neoplasm

Urethral Neoplasms

Neoplasm Of Urethra

Neoplasm. Urethra

Urethral Neoplasm

Urethral Carcinoma

Malignant Neoplasm Of Urethra

Infantile Myofibromatosis

Lipofibromatosis

Myofibromatosis

Pericytoma With T(7;12)
Adenosarcoma

Mullerian Adenosarcoma

Heart Sarcoma

Cardiac Sarcoma

Sarcoma Of Heart

Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma

Spindle Cell Sarcoma

Sarcoma

Sarcoma Spindle Cell

Sarcoma, Spindle Cell

Sarcoma - Category

Adult Fibrosarcoma
Fibrous Histiocytoma

Benign Fibrous Histiocytoma

Histiocytoma, Benign Fibrous

Fibroxanthoma

Histiocytoma Fibrous

Pulmonary Artery Leiomyosarcoma

Leiomyosarcoma Of The Pulmonary Artery

Prolapse Of Urethra

Urethrocele

Bartholin'S Gland Disease

Bartholin Gland Disease

Cutaneous Fibrous Histiocytoma

Dermatofibroma

Fibrohistiocytic Tumor

Benign Cutaneous Fibrous Histiocytoma

Fibrous Histiocytoma Of Skin

Fibrous Xanthoma Of Skin

Pleomorphic Fibroma

Sclerosing Angioma

Sclerosing Angioma Of Skin

Fibrous Histiocytoma

Congenital Granular Cell Tumor
Vaginal Cancer

Malignant Neoplasm Of Vagina

Vaginal Neoplasms

Malignant Tumor Of Vagina

Malignant Vaginal Tumor

Neoplasm Of Vagina

Vagina Neoplasm

Vaginal Tumor

Vaginal Carcinoma

Vaginal Malignant Epithelial Tumor

Vaginal Neoplasm

Malignant Vaginal Neoplasm

Vagina Carcinoma

Vaginal Neoplasia

Cancer Of Vagina

Malignant Tumour Of Vagina

Carcinoma Of Vagina

Primary Malignant Neoplasm Of Vagina

Vagina Wall Cancer

Vaginal Wall Cancer

Mixed Cell Type Cancer

Malignant Mixed Neoplasm

Malignant Mixed Tumor

Mixed Neoplasm

Mixed Tumor, Malignant

Malignant Mixed Cancer

Mixed Tumor

Malignant Mixed Tumor, Not Otherwise Specified

Mixed Salivary Gland Tumor

Mixed Tumor, Not Otherwise Specified

Lipomatosis, Multiple

Lipoma

Familial Multiple Lipomatosis

Lipomatosis, Familial Multiple

Benign Lipomatous Tumor

Lipomatous Neoplasm

Multiple Lipomatosis

Fml

Lipo

Benign Tumor Of Adipose Tissue

Lipomatous Tumor

Tumor Of Adipose Tissue

Neoplasms, Adipose Tissue

Lipomas

Pleomorphic Liposarcoma

Pls

Liposarcoma Pleomorphic

Liposarcoma, Pleomorphic

Endobronchial Lipoma
Gastric Hemangioma

Hemangioma Of Stomach

Sweat Gland Benign Neoplasm

Neoplasm Of Sweat Gland

Sweat Gland Tumor

Tumor Of The Sweat Gland

Sweat Gland Neoplasms

Sweat Gland Neoplasm

Myxosarcoma
Heart Cancer

Malignant Neoplasm Of Heart

Heart Neoplasm

Cardiac Tumor

Malignant Cardiac Tumor

Tumour Of Heart

Heart Neoplasms

Cardiac Carcinoma

Lung Sarcoma

Pulmonary Sarcoma

Myositis Ossificans

Myisitis Ossificans

Ossification - Muscle

Dedifferentiated Liposarcoma

Ddls

Liposarcoma Dedifferentiated

Liposarcoma, Dedifferentiated

Gastric Liposarcoma

Liposarcoma Of The Stomach

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Cervical Adenosarcoma

Cervical Muellerian Adenosarcoma

Cervical Mullerian Adenosarcoma

Neurilemmoma

Schwannoma

Benign Schwannoma

Neurilemoma

Peripheral Fibroblastoma

Psammomatous Schwannoma

Neurolemmoma

Schwannomas

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor

Atypical Lipoma

Alt

Wdls

Liposarcoma, Well Differentiated

Pleomorphic Lipoma

Desmoid Tumor

Aggressive Fibromatosis

Desmoid Type Fibromatosis

Familial Infiltrative Fibromatosis

Desmoid Disorder, Hereditary

Fif

Fibromatosis, Familial Infiltrative

Deep Fibromatosis

Desmoid Fibromatosis

Hereditary Desmoid Disease

Musculoaponeurotic Fibromatosis

Desmoid-Type Fibromatosis

Fibromatosis, Aggressive

Desmoid Disease, Hereditary

Musculo-Aponeurotic Fibromatosis

Dermatofibrosarcoma Protuberans

DFSP

Dermatofibrosarcoma

Giant Cell Fibroblastoma

Metastatic Dermatofibrosarcoma Protuberans

Familial Dermatofibrosarcoma Protuberans

Darier-Ferrand Tumor

Darier-Hoffmann Tumor

Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal

Rhabdomyosarcoma Embryonal

Botryoid Rhabdomyosarcoma

Erms

Spindle Cell Rhabdomyosarcomas

Muscular Disease
Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma

Emc

Myxoid Extraosseous Chondrosarcoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris CALD1 VGNC VGNC:38666
Mus musculus CALD1 MGD MGI:88250
Macaca mulatta CALD1 VGNC VGNC:70517
Felis catus CALD1 VGNC VGNC:60322
Bos taurus CALD1 VGNC VGNC:26706
Rattus norvegicus CALD1 RGD RGD:2256