IRAK2 - interleukin 1 receptor associated kinase 2 Gene

Homo sapiens

Also known as IRAK-2

Gene ID: 3656 | Gene type: protein coding

About IRAK2

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,164,919-10,243,745 (from NCBI)

This gene has 1 transcript (splice variant), 137 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 8.0), urinary bladder (RPKM 5.9) and 22 other tissues.

Summary

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

IRAK2 Products(1)

mRNA	Protein	Name
NM_001570.4	NP_001561.3	interleukin-1 receptor-associated kinase-like 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	17878161	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11544529	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10383454	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10383454	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	17878161	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	17878161	GOA
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	17878161	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRAK2 Protein Structure

Death

Pkinase

0
100
200
300
400
500
625 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor-associated kinase-like 2

IRAK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IRAK2	O43187	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	21988832
Intra	IRAK2	O43187	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	33961781
Intra	IRAK2	O43187	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	28514442
Intra	IRAK2	O43187	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	21903422
Intra	IRAK2	O43187	ARAF	Homo sapiens	P10398	Anti Tag CoIP	21903422
Intra	IRAK2	O43187	TARDBP	Homo sapiens	Q13148	Anti Tag CoIP	21903422
Intra	IRAK2	O43187	IRAK4	Homo sapiens	Q9NWZ3	GMS	20485341
Intra	IRAK2	O43187	IRAK4	Homo sapiens	Q9NWZ3	Pull Down	20485341
Intra	IRAK2	O43187	IRAK4	Homo sapiens	Q9NWZ3	X-Ray Diffraction	20485341
Intra	IRAK2	O43187	TIRAP	Homo sapiens	P58753	Anti Tag CoIP	11544529
Cross	IRAK2	O43187	Sarm1	Mus musculus	Q6PDS3	Anti Tag CoIP	21903422
Intra	IRAK2	O43187	STT3A	Homo sapiens	P46977	Anti Tag CoIP	21903422
Intra	IRAK2	O43187	ZC3H12A	Homo sapiens	Q5D1E8	Anti Tag CoIP	21903422
Cross	IRAK2	O43187	OPG044	Vaccinia virus	P68467	Anti Bait CoIP	18636090

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06896	IRAK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IRAK2	RGD	RGD:1309584
Felis catus	IRAK2	VGNC	VGNC:67820
Mus musculus	IRAK2	MGD	MGI:2429603
Macaca mulatta	IRAK2	VGNC	VGNC:73758
Canis familiaris	IRAK2	VGNC	VGNC:103685
Bos taurus	IRAK2	VGNC	VGNC:30266

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