USP10 - ubiquitin specific peptidase 10 Gene

Homo sapiens

Also known as UBPO

Gene ID: 9100 | Gene type: protein coding

About USP10

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,700,000-84,779,922 (from NCBI)

This gene has 19 transcripts (splice variants), 216 orthologues and 71 paralogues. Ubiquitous expression in placenta (RPKM 15.2), lymph node (RPKM 13.4) and 25 other tissues.

Summary

Ubiquitin is a highly conserved protein that is covalently linked to Other proteins to regulate their function and degradation. This gene encodes a member of the Ubiquitin-Specific Protease family of cysteine proteases. The Enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound Androgen Receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and Others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

USP10 Products(2)

mRNA	Protein	Name
NM_001272075.2	NP_001259004.1	ubiquitin carboxyl-terminal hydrolase 10 isoform 1
NM_005153.3	NP_005144.2	ubiquitin carboxyl-terminal hydrolase 10 isoform 2

USP10 Protein Structure

UCH

0
200
400
600
798 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 10

deubiquitinating enzyme 10

USP10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP10	Q14694	G3BP2	Homo sapiens	Q9UN86	Validated Y2H	25416956
Intra	USP10	Q14694	G3BP2	Homo sapiens	Q9UN86	Y2H Array	25416956
Intra	USP10	Q14694	G3BP2	Homo sapiens	Q9UN86	Anti Tag CoIP	33961781
Intra	USP10	Q14694	G3BP2	Homo sapiens	Q9UN86	Y2H Array	29892012
Intra	USP10	Q14694	G3BP2	Homo sapiens	Q9UN86	Anti Tag CoIP	19615732
Intra	USP10	Q14694	G3BP2	Homo sapiens	Q9UN86	Anti Tag CoIP	33495715
Intra	USP10	Q14694	G3BP1	Homo sapiens	Q13283	Anti Tag CoIP	33961781
Intra	USP10	Q14694	G3BP1	Homo sapiens	Q13283	BiFC	21455491
Intra	USP10	Q14694	G3BP1	Homo sapiens	Q13283	Anti Tag CoIP	19615732
Intra	USP10	Q14694	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	USP10	Q14694	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	USP10	Q14694	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	USP10	Q14694	G3BP2	Homo sapiens	Q9UN86-2	Validated Y2H	32296183
Intra	USP10	Q14694	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	USP10	Q14694	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	USP10	Q14694	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	USP10	Q14694	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	USP10	Q14694	ZC3H12A	Homo sapiens	Q5D1E8	Anti Tag CoIP	24270572
Intra	USP10	Q14694	ZC3H12A	Homo sapiens	Q5D1E8	Anti Bait CoIP	24270572

Cross: Cross-species interaction Intra: Intraspecies interaction

USP10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82617	USP10 Antibody (YA2362)	WB, IHC-F, IHC-P, ICC/IF, IP	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12990	Spautin-1		99.54%	Unkown
HY-153886	Wu-5		99.34%	Unkown
HY-163622	USP10-IN-3	Inducer	98.00%	Unkown
HY-RS15521	USP10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	USP10	VGNC	VGNC:36710
Mus musculus	USP10	MGD	MGI:894652
Macaca mulatta	USP10	VGNC	VGNC:103881
Canis familiaris	USP10	VGNC	VGNC:48178
Rattus norvegicus	USP10	RGD	RGD:1561965
Others	USP10	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.