2. Gene
  3. BRD3 - bromodomain containing 3 Gene

BRD3 - bromodomain containing 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ORFX; RING3L

Gene ID: 8019 | Gene type: protein coding

About BRD3

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:134,030,305-134,068,548 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues, 11 paralogues and is associated with 77 phenotypes. Ubiquitous expression in endometrium (RPKM 8.0), brain (RPKM 7.5) and 25 other tissues.

Summary

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

BRD3 Products(8)

mRNA Protein Name
NM_007371.4 NP_031397.1 bromodomain-containing protein 3
XM_047423904.1 XP_047279860.1 bromodomain-containing protein 3 isoform X1
XM_047423903.1 XP_047279859.1 bromodomain-containing protein 3 isoform X1
XM_047423905.1 XP_047279861.1 bromodomain-containing protein 3 isoform X2
XM_047423906.1 XP_047279862.1 bromodomain-containing protein 3 isoform X2
XM_011519052.3 XP_011517354.1 bromodomain-containing protein 3 isoform X1
XM_017015165.3 XP_016870654.1 bromodomain-containing protein 3 isoform X2
XM_006717291.4 XP_006717354.1 bromodomain-containing protein 3 isoform X1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
18406326 GOA
enables lncRNA binding IDA
IDA: Inferred from direct assay
32895492 GOA
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
22464331 GOA
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
32895492 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20195357 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endodermal cell differentiation IDA
IDA: Inferred from direct assay
32895492 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
32895492 GOA
involved in protein localization to chromatin IDA
IDA: Inferred from direct assay
29567837 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18406326 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
32895492 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25593309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD3 Protein Structure

Bromodomain

Bromodomain: Bromodomain (46 - 126)

Bromodomain

Bromodomain: Bromodomain (315 - 403)

  • 0
  • 200
  • 400
  • 600
  • 726 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 3

RING3-like protein

BRD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BRD3 Q15059 MYC Homo sapiens P01106
Display Tech
20195357
Intra
BRD3 Q15059 MYC Homo sapiens P01106
TAP
20195357
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Foodborne Botulism

Botulism

Botulism Poisoning

Intoxication With Clostridium Botulinum Toxin

Wound Botulism

Food Poisoning Due To Clostridium Botulinum

Infection Due To Clostridium Botulinum

Infant Botulism

Intoxication Botulism

Botulism, Infantile

Clostridium Botulinum Poisoning

Botulism Nos
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Infant Botulism

Infant Intestinal Botulism

Infant Intestinal Toxemia Botulism

Infant Intestinal Toxin-Mediated Botulism

Infantile Botulism

Botulism, Infantile
Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc
Wound Botulism

Cutaneous Infectious Botulism

Cutaneous Toxin-Mediated Botulism

Inoculation Botulism

Skin Infectious Botulism

Skin Toxin-Mediated Botulism
Bladder Sarcoma

Sarcoma Of Bladder

Sarcoma Of The Urinary Bladder
Intestinal Botulism

Intestinal Colonization Botulism

Intestinal Toxemia Botulism

Intestinal Toxin-Mediated Botulism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100972 ARV-771 Inhibitor 99.87% Unkown
HY-136570 GSK778 Inhibitor 98.93% Unkown
HY-136571 GSK046 Inhibitor 99.65% Unkown
HY-141438 SIM1 Inhibitor 99.57% Unkown
HY-101519 BETd-260 Inhibitor 99.59% Unkown
HY-112429 HJB97 Inhibitor 98.05% Unkown
HY-138563 GSK973 Inhibitor 99.97% Unkown
HY-120000 MS402 Inhibitor 99.62% Unkown
HY-114504 RVX-297 Inhibitor 95.00% Unkown
HY-130622 LT052 Inhibitor 98.77% Unkown
HY-112610 CF53 Inhibitor 99.78% Unkown
HY-145264 OARV-771 Inhibitor 98.33% Unkown
HY-114416 GS-626510 Inhibitor 99.80% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-170390 AB3067 Degrader / Unkown
HY-170380 XY221 Inhibitor / Unkown
HY-168634 SJ46421 Inhibitor / Unkown
HY-169170 PARP1/BRD4-IN-3 Inhibitor / Unkown
HY-168635 SJ46420 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BRD3 VGNC VGNC:60167
Mus musculus BRD3 MGD MGI:1914632
Bos taurus BRD3 VGNC VGNC:26558
Macaca mulatta BRD3 VGNC VGNC:70281
Canis familiaris BRD3 VGNC VGNC:103661
Rattus norvegicus BRD3 RGD RGD:1308925
Others BRD3 NCBI