FKBP6 - FKBP prolyl isomerase family member 6 (inactive) Gene

Homo sapiens

Also known as FKBP36; SPGF77

Gene ID: 8468 | Gene type: protein coding

About FKBP6

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,328,161-73,358,625 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues, 18 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 29.4).

Summary

The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

FKBP6 Products(4)

mRNA	Protein	Name
NM_001135211.3	NP_001128683.1	inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform b
NM_001281304.2	NP_001268233.1	inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform c
NM_001362789.2	NP_001349718.1	inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform d
NM_003602.5	NP_003593.3	inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26567527	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	26567527	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP6 Protein Structure

FKBP_C

0
100
200
300
327 a.a.

Protein Preferred Names

Protein Names

inactive peptidyl-prolyl cis-trans isomerase FKBP6

36 kDa FKBP

FKBP6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FKBP6	O75344	SUMO1P1	Homo sapiens	G2XKQ0	Validated Y2H	25910212
Intra	FKBP6	O75344	SUMO1P1	Homo sapiens	G2XKQ0	Y2H Array	25910212
Intra	FKBP6	O75344	SUMO1P1	Homo sapiens	G2XKQ0	Validated Y2H	25416956
Intra	FKBP6	O75344	SUMO1P1	Homo sapiens	G2XKQ0	Y2H Bait-Prey Pool	25910212
Intra	FKBP6	O75344	RAB11FIP2	Homo sapiens	Q7L804	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	RAB11FIP2	Homo sapiens	Q7L804	Validated Y2H	32296183
Intra	FKBP6	O75344	RAB11FIP2	Homo sapiens	Q7L804	Y2H Array	32296183
Intra	FKBP6	O75344	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	FKBP6	O75344	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	FKBP6	O75344	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	DLGAP4	Homo sapiens	Q9Y2H0-1	Validated Y2H	32296183
Intra	FKBP6	O75344	DLGAP4	Homo sapiens	Q9Y2H0-1	Y2H Array	32296183
Intra	FKBP6	O75344	DLGAP4	Homo sapiens	Q9Y2H0-1	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	FKBP6	O75344	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
Intra	FKBP6	O75344	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	FKBP6	O75344	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	FKBP6	O75344	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	FKBP6	O75344	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	FKBP6	O75344	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	FKBP6	O75344	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	FKBP6	O75344	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	FKBP6	O75344	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	FKBP6	O75344	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	FKBP6	O75344	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	FKBP6	O75344	OSBP	Homo sapiens	P22059	Anti Tag CoIP	33961781
Intra	FKBP6	O75344	OSBP	Homo sapiens	P22059	Anti Tag CoIP	28514442
Intra	FKBP6	O75344	OSBP	Homo sapiens	P22059	Anti Tag CoIP	25036637
Intra	FKBP6	O75344	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	KRT75	Homo sapiens	O95678	Validated Y2H	32296183
Intra	FKBP6	O75344	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	FKBP6	O75344	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	FKBP6	O75344	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	PIAS2	Homo sapiens	O75928-2	Validated Y2H	32296183
Intra	FKBP6	O75344	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	FKBP6	O75344	GAPDH	Homo sapiens	P04406	Y2H Pooling	32814053
Intra	FKBP6	O75344	GAPDH	Homo sapiens	P04406	Validated Y2H	32814053
Intra	FKBP6	O75344	GAPDH	Homo sapiens	P04406	Y2H Array	32814053
Intra	FKBP6	O75344	STUB1	Homo sapiens	Q9UNE7	Validated Y2H	32814053
Intra	FKBP6	O75344	STUB1	Homo sapiens	Q9UNE7	Y2H Array	32814053
Intra	FKBP6	O75344	STUB1	Homo sapiens	Q9UNE7	Y2H Pooling	32814053
Intra	FKBP6	O75344	ALDH3A1	Homo sapiens	P30838	Validated Y2H	32296183
Intra	FKBP6	O75344	ALDH3A1	Homo sapiens	P30838	Y2H Array	32296183
Intra	FKBP6	O75344	ALDH3A1	Homo sapiens	P30838	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	EEF1D	Homo sapiens	P29692-2	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	EEF1D	Homo sapiens	P29692-2	Validated Y2H	32296183
Intra	FKBP6	O75344	EEF1D	Homo sapiens	P29692-2	Y2H Array	32296183
Intra	FKBP6	O75344	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	FKBP6	O75344	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	FKBP6	O75344	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	CDK5RAP3	Homo sapiens	Q96JB5	Y2H Array	32296183
Intra	FKBP6	O75344	CDK5RAP3	Homo sapiens	Q96JB5	Validated Y2H	32296183
Intra	FKBP6	O75344	CDK5RAP3	Homo sapiens	Q96JB5	Validated Y2H	25910212
Intra	FKBP6	O75344	CDK5RAP3	Homo sapiens	Q96JB5	Y2H Array	31515488
Intra	FKBP6	O75344	CDK5RAP3	Homo sapiens	Q96JB5	Y2H Bait-Prey Pool	25910212
Intra	FKBP6	O75344	CDK5RAP3	Homo sapiens	Q96JB5	Y2H Array	25910212
Intra	FKBP6	O75344	CDK5RAP3	Homo sapiens	Q96JB5	Validated Y2H	25416956
Intra	FKBP6	O75344	CDK5RAP3	Homo sapiens	Q96JB5	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	TMEM9B	Homo sapiens	Q9NQ34	Validated Y2H	32296183
Intra	FKBP6	O75344	FKBP8	Homo sapiens	Q14318	Anti Tag CoIP	26567527
Intra	FKBP6	O75344	CRACR2A	Homo sapiens	Q9BSW2	Validated Y2H	32296183
Intra	FKBP6	O75344	CBS	Homo sapiens	P35520	Validated Y2H	32814053
Intra	FKBP6	O75344	CBS	Homo sapiens	P35520	Y2H Pooling	32814053
Intra	FKBP6	O75344	CBS	Homo sapiens	P35520	Y2H Array	32814053
Intra	FKBP6	O75344	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25910212
Intra	FKBP6	O75344	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25910212
Intra	FKBP6	O75344	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	FKBP6	O75344	LZTS2	Homo sapiens	Q9BRK4	Y2H Bait-Prey Pool	25910212
Intra	FKBP6	O75344	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	FKBP6	O75344	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	FKBP6	O75344	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	FKBP6	O75344	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	FKBP6	O75344	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	25910212
Intra	FKBP6	O75344	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956
Intra	FKBP6	O75344	IHO1	Homo sapiens	Q8IYA8	Y2H Bait-Prey Pool	25910212
Intra	FKBP6	O75344	IHO1	Homo sapiens	Q8IYA8	Y2H Array	25910212
Intra	FKBP6	O75344	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	25416956
Intra	FKBP6	O75344	NME7	Homo sapiens	Q9Y5B8	Y2H Pooling	16189514
Intra	FKBP6	O75344	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	FKBP6	O75344	MEOX2	Homo sapiens	P50222	Y2H Bait-Prey Pool	25910212
Intra	FKBP6	O75344	MEOX2	Homo sapiens	P50222	Validated Y2H	25910212
Intra	FKBP6	O75344	MEOX2	Homo sapiens	P50222	Y2H Array	25910212
Intra	FKBP6	O75344	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	FKBP6	O75344	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	FKBP6	O75344	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	CFP	Homo sapiens	P27918	Y2H Array	32296183
Intra	FKBP6	O75344	CFP	Homo sapiens	P27918	Y2H Prey Pooling	32296183
Intra	FKBP6	O75344	CFP	Homo sapiens	P27918	Validated Y2H	32296183
Cross	FKBP6	O75344	Usp19	Mus musculus	Q3UJD6-2	Lumier	25036637
Intra	FKBP6	O75344	ECM1	Homo sapiens	Q16610	Validated Y2H	32296183
Intra	FKBP6	O75344	ECM1	Homo sapiens	Q16610	Y2H Array	32296183
Intra	FKBP6	O75344	ECM1	Homo sapiens	Q16610	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

FKBP6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83175	FKBP6 Antibody (YA2920)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 2

Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss	EDSKSCL2
Edskmh	Ehlers-Danlos Syndrome Kyphoscoliotic Type 2
Kyphoscoliotic Ehlers-Danlos Syndrome Due To Fkbp22 Deficiency	Ehlers-Danlos Syndrome With Kyphoscoliosis, Myopathy, And Deafness
Ehlers-Danlos Syndrome With Kyphoscoliosis, Myopathy, And Hearing Loss	Fkbp14-Related Eds
Fkbp22-Deficient Eds	Kyphoscoliotic Eds Due To Fkbp22 Deficiency
Keds-Fkbp14	Ehlers-Danlos Syndrome, With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss
Ehlers-Danlos Syndrome, Kyphoscoliotic, Type 2

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Supravalvular Aortic Stenosis

SVAS	Supravalvar Aortic Stenosis
Supravalvar Aortic Stenosis, Eisenberg Type	Aortic Supravalvular Stenosis
Aortic Stenosis, Supravalvular	Supra-Valvular Aortic Stenosis
Stenosis, Aortic Supravalvular	Stenosis, Supravalvular Aortic
Supravalvular Stenosis, Aortic	Aortic Stenosis Supravalvular

Williams-Beuren Region Duplication Syndrome

7q11.23 Duplication Syndrome	7q11.23 Microduplication Syndrome
Chromosome 7q11.23 Duplication Syndrome	Wbs Duplication Syndrome
Somerville-Van Der Aa Syndrome	Dup(7)(Q11.23)
Trisomy 7q11.23	William-Beuren Region Duplication Syndrome
Chromosome 7q11.23 Duplication

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Chromosome 17q12 Deletion Syndrome

17q12 Microdeletion Syndrome	Del(17)(Q12)
Monosomy 17q12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04966	FKBP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FKBP6	RGD	RGD:1308926
Macaca mulatta	FKBP6	VGNC	VGNC:72666
Mus musculus	FKBP6	MGD	MGI:2137612
Felis catus	FKBP6	VGNC	VGNC:62282
Bos taurus	FKBP6	VGNC	VGNC:29025
Canis familiaris	FKBP6	VGNC	VGNC:40892

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