2. Gene
  3. NCOA4 - nuclear receptor coactivator 4 Gene

NCOA4 - nuclear receptor coactivator 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RFG; ELE1; PTC3; ARA70

Gene ID: 8031 | Gene type: protein coding

About NCOA4

Cytogenetic location: 10q11.22 Genomic coordinates (GRCh38): 10:46,005,088-46,030,623 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and is associated with 17 phenotypes. Ubiquitous expression in duodenum (RPKM 113.8), liver (RPKM 75.2) and 25 other tissues.

Summary

This gene encodes an Androgen Receptor coactivator. The encoded protein interacts with the Androgen Receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the RET tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

NCOA4 Products(5)

mRNA Protein Name
NM_001145260.2 NP_001138732.1 nuclear receptor coactivator 4 isoform 1
NM_001145261.2 NP_001138733.1 nuclear receptor coactivator 4 isoform 2
NM_001145262.2 NP_001138734.1 nuclear receptor coactivator 4 isoform 3
NM_001145263.2 NP_001138735.1 nuclear receptor coactivator 4 isoform 3
NM_005437.4 NP_005428.1 nuclear receptor coactivator 4 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within protein targeting to lysosome IDA
IDA: Inferred from direct assay
25327288 GOA
Cellular Component GO Annotation Evidence Reference Source
located in autolysosome IDA
IDA: Inferred from direct assay
25327288 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCOA4 Protein Structure

ARA70

ARA70: Nuclear coactivator (37 - 167)

ARA70

ARA70: Nuclear coactivator (198 - 332)

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  • 500
  • 614 a.a.
Protein Preferred Names Protein Names

nuclear receptor coactivator 4

70 kDa AR-activator

NCOA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NCOA4 Q13772 FTL Homo sapiens P02792
Anti Tag CoIP
33961781
Intra
NCOA4 Q13772 FTL Homo sapiens P02792
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma
Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome
Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary
Hashimoto Thyroiditis

Autoimmune Thyroiditis

Hashimoto Struma

Hashimoto'S Thyroiditis

Chronic Lymphocytic Thyroiditis

Lymphocytic Thyroiditis

Hashimoto Disease

Ht

Hashimoto'S Disease

Hashimoto'S Syndrome

Hypothyroidism, Autoimmune

Autoimmune Chronic Lymphocytic Thyroiditis

Chronic Lymphocytic Thyroiditides

Hashimoto Syndrome

Hashimotos Thyroiditis

Hashimoto Thyroiditis, Susceptibility To

Thyroiditis, Autoimmune

Lymphomatous Thyroiditis

Lymphoid Thyroiditis

Chronic Lymphadenoid Thyroiditis

Autoimmune Lymphocytic Chronic Thyroiditis

Goitre Lymphomatosa

Hashitoxicosis

Hashimoto Hypothyroidism

Lymphadenoid Goitre

Struma Lymphomatosa

Hyperthyroidism With Hashimoto Disease

Hashimoto Thyrotoxicosis

Thyrotoxicosis Due To Hashimoto Thyroiditis

Struma Lymphomatosis

Lymphadenoid Struma
Thyroid Gland Cancer

Thyroid Gland Carcinoma

Malignant Neoplasm Of Thyroid Gland

Malignant Tumour Of Thyroid Gland

Thyroid Neoplasm

Thyroid Neoplasms

Neoplasm Of Thyroid Gland

Thyroid Gland Neoplasm

Head And Neck Cancer, Thyroid

Neoplasm Of The Thyroid Gland

Cancer Of The Thyroid

Primary Malignant Neoplasm Of Thyroglossal Duct

Malignant Neoplasm Of Thyroglossal Duct

Primary Malignant Neoplasm Of Thyroid Gland

Thyroglossal Duct Cancer

Toxic Goitre Malignant Tumour

Cancerous Goitre
Benign Struma Ovarii
Multiple Endocrine Neoplasia, Type Iib

Multiple Endocrine Neoplasia Type 2b

MEN2B

Wagenmann-Froboese Syndrome

Multiple Endocrine Neoplasia Iib

Mucosal Neuroma Syndrome

Multiple Endocrine Neoplasia, Type 3

Multiple Endocrine Neoplasia, Type 2b

Men Iib

Neuromata, Mucosal, With Endocrine Tumors

Multiple Endocrine Neoplasia, Type Iii, Formerly

Men3, Formerly

Men Type Iib

Men 2b

Multiple Endocrine Neoplasia Type 3

Multiple Neoplasia 2b

Neoplasia, Endocrine, Multiple, Type Iib
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Ovarian Germ Cell Teratoma

Germ Cell Teratoma Of Ovary

Ovarian Teratoma
Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma

Follicular Adenocarcinoma

Follicular Adenocarcinoma, Well Differentiated

Follicular Carcinoma

Thyroid Adenocarcinoma

Adenocarcinoma, Follicular
Struma Ovarii
Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma

Medullary Carcinoma Of The Thyroid Gland

Ultimobranchial Thyroid Tumor

Ultimobranchial Thyroid Tumour

Thyroid Cancer, Medullary
Malignant Struma Ovarii

Struma Ovarii, Malignant
Multinodular Goiter
Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-163897 PROTAC NCOA4 degrader-1 Inhibitor 99.42% Unkown
HY-RS09092 NCOA4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-173119 SKLB-D18 / Unkown
HY-138678B (S,R,R)-VH032 / Unkown
HY-163904 (S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH / Unkown
HY-168894 CT-1 Inducer / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NCOA4 VGNC VGNC:68433
Rattus norvegicus NCOA4 RGD RGD:1563014
Mus musculus NCOA4 MGD MGI:1350932
Macaca mulatta NCOA4 VGNC VGNC:97794
Canis familiaris NCOA4 VGNC VGNC:43661
Bos taurus NCOA4 VGNC VGNC:31922