2. Gene
  3. ZKSCAN3 - zinc finger with KRAB and SCAN domains 3 Gene

ZKSCAN3 - zinc finger with KRAB and SCAN domains 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZF47; Zfp47; ZFP306; ZNF306; ZNF309; zfp-47; ZSCAN13; ZSCAN35; dJ874C20.1; dJ874C20.1.

Gene ID: 80317 | Gene type: protein coding

About ZKSCAN3

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:28,349,878-28,369,172 (from NCBI)

This gene has 3 transcripts (splice variants), 38 orthologues and 31 paralogues. Ubiquitous expression in thyroid (RPKM 1.5), ovary (RPKM 1.5) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of cellular senescence; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZKSCAN3 Products(3)

mRNA Protein Name
NM_001242894.2 NP_001229823.1 zinc finger protein with KRAB and SCAN domains 3 isoform 1
NM_001242895.2 NP_001229824.1 zinc finger protein with KRAB and SCAN domains 3 isoform 2
NM_024493.4 NP_077819.2 zinc finger protein with KRAB and SCAN domains 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
18940803 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
23434374 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18940803 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18940803 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
18940803 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23434374 GOA
Biological Process GO Annotation Evidence Reference Source
involved in lysosome organization IMP
IMP: Inferred from mutant phenotype
23434374 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23434374 GOA
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
23434374 GOA
involved in negative regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
23434374 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18940803 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18940803 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23434374 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18940803 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZKSCAN3 Protein Structure

SCAN

SCAN: SCAN domain (42 - 134)

KRAB

KRAB: KRAB box (217 - 253)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (328 - 351)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (356 - 381)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (385 - 408)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (412 - 436)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (495 - 519)

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  • 500
  • 538 a.a.
Protein Preferred Names Protein Names

zinc finger protein with KRAB and SCAN domains 3

zinc finger and SCAN domain-containing protein 13

ZKSCAN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZKSCAN3 Q9BRR0 FKBP1A Homo sapiens Q0VDC6
Y2H Pooling
32814053
Intra
ZKSCAN3 Q9BRR0 FKBP1A Homo sapiens Q0VDC6
Validated Y2H
32814053
Intra
ZKSCAN3 Q9BRR0 FKBP1A Homo sapiens Q0VDC6
Y2H Array
32814053
Intra
ZKSCAN3 Q9BRR0 SARS1 Homo sapiens P49591
Validated Y2H
32814053
Intra
ZKSCAN3 Q9BRR0 SARS1 Homo sapiens P49591
Y2H Array
32814053
Intra
ZKSCAN3 Q9BRR0 SARS1 Homo sapiens P49591
Y2H Pooling
32814053
Intra
ZKSCAN3 Q9BRR0 EIF2S3 Homo sapiens P41091
Validated Y2H
32814053
Intra
ZKSCAN3 Q9BRR0 EIF2S3 Homo sapiens P41091
Y2H Array
32814053
Intra
ZKSCAN3 Q9BRR0 EIF2S3 Homo sapiens P41091
Y2H Pooling
32814053
Intra
ZKSCAN3 Q9BRR0 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
ZKSCAN3 Q9BRR0 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
ZKSCAN3 Q9BRR0 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
ZKSCAN3 Q9BRR0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ZKSCAN3 Q9BRR0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ZKSCAN3 Q9BRR0 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
ZKSCAN3 Q9BRR0 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
ZKSCAN3 Q9BRR0 MDM4 Homo sapiens O15151
Y2H Array
32296183
Intra
ZKSCAN3 Q9BRR0 MDM4 Homo sapiens O15151
Y2H Prey Pooling
32296183
Intra
ZKSCAN3 Q9BRR0 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
ZKSCAN3 Q9BRR0 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
ZKSCAN3 Q9BRR0 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
ZKSCAN3 Q9BRR0 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
ZKSCAN3 Q9BRR0 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
ZKSCAN3 Q9BRR0 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
ZKSCAN3 Q9BRR0 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
ZKSCAN3 Q9BRR0 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
ZKSCAN3 Q9BRR0 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Intra
ZKSCAN3 Q9BRR0 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra
ZKSCAN3 Q9BRR0 PDE4DIP Homo sapiens Q5VU43-2
Y2H Array
32296183
Intra
ZKSCAN3 Q9BRR0 PDE4DIP Homo sapiens Q5VU43-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Non-Invasive Bladder Papillary Urothelial Neoplasm

Bladder Papillary Neoplasm Of Low Malignant Potential

Bladder Punlmp

Papillary Urothelial Neoplasm Of Low Malignant Potential

Papillary Transitional Cell Neoplasm Of Low Malignant Potential
Ureteral Benign Neoplasm

Neoplasm Of Ureter

Ureteral Tumor

Cancer Of The Ureter

Malignant Tumour Of Ureter

Ureteric Cancer

Primary Malignant Neoplasm Of Ureter
Alzheimer Disease 4

AD4

Alzheimer Disease-4

Alzheimer'S Disease 4

Alzheimer Disease, Familial, 4

Alzheimer Disease, Familial4

Alzheimer'S Disease 4, Early Onset

Alzheimer Disease, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16082 ZKSCAN3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZKSCAN3 VGNC VGNC:78938
Rattus norvegicus ZKSCAN3 RGD RGD:1305753
Mus musculus ZKSCAN3 MGD MGI:1919989