IHO1 - interactor of HORMAD1 1 Gene

Homo sapiens

Also known as CT74; LELA1; CCDC36

Gene ID: 339834 | Gene type: protein coding

About IHO1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,191,309-49,258,106 (from NCBI)

This gene has 5 transcripts (splice variants) and 117 orthologues. Biased expression in testis (RPKM 12.6), fat (RPKM 1.6) and 1 other tissue.

Summary

Predicted to be involved in gamete generation; meiosis I cell cycle process; and regulation of homologous chromosome segregation. Predicted to be active in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Apr 2022]

IHO1 Products(2)

mRNA	Protein	Name
NM_001135197.2	NP_001128669.1	interactor of HORMAD1 protein 1
NM_178173.4	NP_835467.2	interactor of HORMAD1 protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interactor of HORMAD1 protein 1

cancer/testis antigen 74

IHO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IHO1	Q8IYA8	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	IQUB	Homo sapiens	Q8NA54	Y2H Array	31515488
Intra	IHO1	Q8IYA8	IQUB	Homo sapiens	Q8NA54	Y2H Array	25416956
Intra	IHO1	Q8IYA8	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	RUNX1T1	Homo sapiens	Q06455-4	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	NGB	Homo sapiens	Q9NPG2	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	NGB	Homo sapiens	Q9NPG2	Y2H Array	25416956
Intra	IHO1	Q8IYA8	NGB	Homo sapiens	Q9NPG2	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	PRKAB2	Homo sapiens	O43741	Validated Y2H	27107012
Intra	IHO1	Q8IYA8	COX5B	Homo sapiens	P10606	Y2H	21516116
Intra	IHO1	Q8IYA8	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	IHO1	Q8IYA8	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	IHO1	Q8IYA8	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	IHO1	Q8IYA8	PRR34	Homo sapiens	Q9NV39	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	FAM124B	Homo sapiens	Q9H5Z6-2	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	RABGEF1	Homo sapiens	Q9UJ41-4	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	KLC3	Homo sapiens	Q6P597	Y2H Array	25416956
Intra	IHO1	Q8IYA8	KLC3	Homo sapiens	Q6P597	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	ZKSCAN3	Homo sapiens	Q9BRR0	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	FANCL	Homo sapiens	Q9NW38	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	FANCL	Homo sapiens	Q9NW38	Y2H Array	25416956
Intra	IHO1	Q8IYA8	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	IHO1	Q8IYA8	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	IHO1	Q8IYA8	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	IHO1	Q8IYA8	USP20	Homo sapiens	Q9Y2K6	Y2H Array	25416956
Intra	IHO1	Q8IYA8	USP20	Homo sapiens	Q9Y2K6	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	KLHL11	Homo sapiens	Q9NVR0	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	DYNLL1	Homo sapiens	P63167	Y2H Array	25416956
Intra	IHO1	Q8IYA8	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	HEXIM2	Homo sapiens	Q96MH2	Y2H Array	25416956
Intra	IHO1	Q8IYA8	STK25	Homo sapiens	O00506	Y2H Array	25416956
Intra	IHO1	Q8IYA8	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	IHO1	Q8IYA8	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	IHO1	Q8IYA8	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	NEK6	Homo sapiens	Q9HC98	Y2H Array	25416956
Intra	IHO1	Q8IYA8	GYS1	Homo sapiens	P13807	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	GYS1	Homo sapiens	P13807	Y2H Array	25416956
Intra	IHO1	Q8IYA8	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	EXOC8	Homo sapiens	Q8IYI6	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	DYNLL2	Homo sapiens	Q96FJ2	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	DYNLL2	Homo sapiens	Q96FJ2	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	DYNLL2	Homo sapiens	Q96FJ2	Y2H Array	25416956
Intra	IHO1	Q8IYA8	USP2	Homo sapiens	O75604	Y2H Array	25416956
Intra	IHO1	Q8IYA8	ABI2	Homo sapiens	Q9NYB9	Y2H	21516116
Intra	IHO1	Q8IYA8	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	IHO1	Q8IYA8	ABI2	Homo sapiens	Q9NYB9	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	FAM124A	Homo sapiens	Q86V42	Y2H Array	25416956
Intra	IHO1	Q8IYA8	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	FKBP6	Homo sapiens	O75344	Y2H Array	25416956
Intra	IHO1	Q8IYA8	FKBP6	Homo sapiens	O75344	Y2H Array	29892012
Intra	IHO1	Q8IYA8	FKBP6	Homo sapiens	O75344	Y2H Array	31515488
Intra	IHO1	Q8IYA8	AQP1	Homo sapiens	P29972	Y2H Prey Pooling	25416956
Intra	IHO1	Q8IYA8	MAGOHB	Homo sapiens	Q96A72	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
Intra	IHO1	Q8IYA8	CFAP206	Homo sapiens	Q8IYR0	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	KIF9	Homo sapiens	Q9HAQ2	Y2H Prey Pooling	32296183
Intra	IHO1	Q8IYA8	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	IHO1	Q8IYA8	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Infertility

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06655	IHO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IHO1	MGD	MGI:3612242
Felis catus	IHO1	VGNC	VGNC:60498
Bos taurus	IHO1	VGNC	VGNC:26893
Macaca mulatta	IHO1	VGNC	VGNC:110359
Rattus norvegicus	IHO1	RGD	RGD:1596869
Canis familiaris	IHO1	VGNC	VGNC:38836

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