L3MBTL2 - L3MBTL histone methyl-lysine binding protein 2 Gene

Homo sapiens

Also known as L3MBT; H-l(3)mbt-l

Gene ID: 83746 | Gene type: protein coding

About L3MBTL2

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,205,312-41,231,271 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 7.9), testis (RPKM 7.9) and 25 other tissues.

Summary

Enables methylated histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

L3MBTL2 Products(1)

mRNA	Protein	Name
NM_031488.5	NP_113676.2	lethal(3)malignant brain tumor-like protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone binding	IPI IPI: Inferred from physical interaction	17540172	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	19233876	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

L3MBTL2 Protein Structure

MBT

0
200
400
600
705 a.a.

Protein Preferred Names

Protein Names

lethal(3)malignant brain tumor-like protein 2

H-l(3)mbt-like protein 2

L3MBTL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	L3MBTL2	Q969R5	TEKT1	Homo sapiens	Q969V4	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	TEKT1	Homo sapiens	Q969V4	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	TEKT1	Homo sapiens	Q969V4	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	26871637
Intra	L3MBTL2	Q969R5	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	26871637
Intra	L3MBTL2	Q969R5	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	26871637
Intra	L3MBTL2	Q969R5	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	TBC1D9B	Homo sapiens	Q66K14-2	Validated Y2H	25416956
Intra	L3MBTL2	Q969R5	TBC1D9B	Homo sapiens	Q66K14-2	Y2H Array	25416956
Intra	L3MBTL2	Q969R5	TBC1D9B	Homo sapiens	Q66K14-2	Y2H Prey Pooling	25416956
Intra	L3MBTL2	Q969R5	PHF10	Homo sapiens	Q8WUB8-2	Y2H Prey Pooling	25416956
Intra	L3MBTL2	Q969R5	PHF10	Homo sapiens	Q8WUB8-2	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	PHF10	Homo sapiens	Q8WUB8-2	Y2H Array	25416956
Intra	L3MBTL2	Q969R5	PHF10	Homo sapiens	Q8WUB8-2	Validated Y2H	25416956
Intra	L3MBTL2	Q969R5	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	NRF1	Homo sapiens	Q16656-4	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	NRF1	Homo sapiens	Q16656-4	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZNF467	Homo sapiens	Q7Z7K2	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	ZNF467	Homo sapiens	Q7Z7K2	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	RBAK	Homo sapiens	Q9NYW8	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	RBAK	Homo sapiens	Q9NYW8	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	RBAK	Homo sapiens	Q9NYW8	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	TBC1D9B	Homo sapiens	A1L3A9	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	TBC1D9B	Homo sapiens	A1L3A9	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	BIVM	Homo sapiens	Q86UB2	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	BIVM	Homo sapiens	Q86UB2	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	SSUH2	Homo sapiens	Q9Y2M2-2	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	SSUH2	Homo sapiens	Q9Y2M2-2	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	SSUH2	Homo sapiens	Q9Y2M2-2	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZFY	Homo sapiens	P08048	Y2H Prey Pooling	26871637
Intra	L3MBTL2	Q969R5	ZFY	Homo sapiens	P08048	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZFY	Homo sapiens	P08048	Validated Y2H	26871637
Intra	L3MBTL2	Q969R5	ZFY	Homo sapiens	P08048	Y2H Array	26871637
Intra	L3MBTL2	Q969R5	ZFY	Homo sapiens	P08048	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	ZNF829	Homo sapiens	Q3KNS6-3	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZNF829	Homo sapiens	Q3KNS6-3	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	FAM217B	Homo sapiens	Q9NTX9	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	FAM217B	Homo sapiens	Q9NTX9	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	FAM217B	Homo sapiens	Q9NTX9	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	EIF4ENIF1	Homo sapiens	Q9NRA8	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	EIF4ENIF1	Homo sapiens	Q9NRA8	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	MEAF6	Homo sapiens	Q9HAF1	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	MEAF6	Homo sapiens	Q9HAF1	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	25416956
Intra	L3MBTL2	Q969R5	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
Intra	L3MBTL2	Q969R5	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	25416956
Intra	L3MBTL2	Q969R5	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	HDAC3	Homo sapiens	O15379	Pull Down	20385135
Intra	L3MBTL2	Q969R5	HDAC3	Homo sapiens	O15379	Anti Bait CoIP	20385135
Intra	L3MBTL2	Q969R5	HDAC3	Homo sapiens	O15379	Anti Tag CoIP	20385135
Intra	L3MBTL2	Q969R5	HDAC3	Homo sapiens	O15379	Y2H	20385135
Intra	L3MBTL2	Q969R5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	CCDC106	Homo sapiens	Q9BWC9	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	CCDC106	Homo sapiens	Q9BWC9	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	CCDC106	Homo sapiens	Q9BWC9	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZFP64	Homo sapiens	Q9NTW7	Y2H Prey Pooling	26871637
Intra	L3MBTL2	Q969R5	ZFP64	Homo sapiens	Q9NTW7	Validated Y2H	26871637
Intra	L3MBTL2	Q969R5	ZFP64	Homo sapiens	Q9NTW7	Y2H Array	26871637
Intra	L3MBTL2	Q969R5	PAICS	Homo sapiens	P22234	Validated Y2H	25416956
Intra	L3MBTL2	Q969R5	PAICS	Homo sapiens	P22234	Validated Y2H	26871637
Intra	L3MBTL2	Q969R5	PAICS	Homo sapiens	P22234	Y2H Array	26871637
Intra	L3MBTL2	Q969R5	PAICS	Homo sapiens	P22234	Y2H Prey Pooling	26871637
Intra	L3MBTL2	Q969R5	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	L3MBTL2	Q969R5	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	L3MBTL2	Q969R5	TSPYL	Homo sapiens	Q6FI91	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	TSPYL	Homo sapiens	Q6FI91	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	GKAP1	Homo sapiens	Q5VSY0	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	GKAP1	Homo sapiens	Q5VSY0	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZBTB48	Homo sapiens	P10074	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	ZBTB48	Homo sapiens	P10074	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	STAC3	Homo sapiens	Q96MF2	Y2H Prey Pooling	26871637
Intra	L3MBTL2	Q969R5	STAC3	Homo sapiens	Q96MF2	Validated Y2H	26871637
Intra	L3MBTL2	Q969R5	STAC3	Homo sapiens	Q96MF2	Y2H Array	26871637
Intra	L3MBTL2	Q969R5	STAC3	Homo sapiens	Q96MF2	Validated Y2H	25416956
Intra	L3MBTL2	Q969R5	TNNI1	Homo sapiens	P19237	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	TNNI1	Homo sapiens	P19237	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	MAX	Homo sapiens	P61244	Pull Down	25609649
Intra	L3MBTL2	Q969R5	MAX	Homo sapiens	P61244	TAP	25609649
Intra	L3MBTL2	Q969R5	MAX	Homo sapiens	P61244	Anti Tag CoIP	33961781
Intra	L3MBTL2	Q969R5	MAX	Homo sapiens	P61244	TAP	24981860
Intra	L3MBTL2	Q969R5	MAX	Homo sapiens	P61244	TAP	27705803
Intra	L3MBTL2	Q969R5	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	L3MBTL2	Q969R5	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	L3MBTL2	Q969R5	TRIM50	Homo sapiens	Q86XT4	Y2H Prey Pooling	32296183
Intra	L3MBTL2	Q969R5	TRIM50	Homo sapiens	Q86XT4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Idh-Mutant Anaplastic Astrocytoma

Idh-Wildtype Anaplastic Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07485	L3MBTL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	L3MBTL2	VGNC	VGNC:42558
Felis catus	L3MBTL2	VGNC	VGNC:63182
Macaca mulatta	L3MBTL2	VGNC	VGNC:74074
Bos taurus	L3MBTL2	VGNC	VGNC:30763
Mus musculus	L3MBTL2	MGD	MGI:2443584
Rattus norvegicus	L3MBTL2	RGD	RGD:1308569

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