1. Gene
  2. RAF1 - Raf-1 proto-oncogene, serine/threonine kinase Gene

RAF1 - Raf-1 proto-oncogene, serine/threonine kinase Gene

Homo sapiens

Also known as NS5; CRAF; Raf-1; c-Raf; CMD1NN

Gene ID: 5894 | Gene type: protein coding

About RAF1

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,583,601-12,664,117 (from NCBI)

This gene has 74 transcripts (splice variants), 221 orthologues, 23 paralogues and is associated with 85 phenotypes. Ubiquitous expression in bone marrow (RPKM 34.4), heart (RPKM 32.5) and 25 other tissues.

Summary

This gene is the cellular homolog of viral Raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, Apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

RAF1 Products(16)

mRNA Protein Name
NM_001354693.3 NP_001341622.1 RAF proto-oncogene serine/threonine-protein kinase isoform d
NM_001354695.3 NP_001341624.1 RAF proto-oncogene serine/threonine-protein kinase isoform f
NM_001354689.3 NP_001341618.1 RAF proto-oncogene serine/threonine-protein kinase isoform a
NM_001354690.3 NP_001341619.1 RAF proto-oncogene serine/threonine-protein kinase isoform b
NM_002880.4 NP_002871.1 RAF proto-oncogene serine/threonine-protein kinase isoform b
XM_047448651.1 XP_047304607.1 RAF proto-oncogene serine/threonine-protein kinase isoform X2
NM_001354691.3 NP_001341620.1 RAF proto-oncogene serine/threonine-protein kinase isoform c
NR_148941.3
XM_011533974.3 XP_011532276.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1
NM_001354694.3 NP_001341623.1 RAF proto-oncogene serine/threonine-protein kinase isoform e
XM_017006966.1 XP_016862455.1 RAF proto-oncogene serine/threonine-protein kinase isoform X2
NR_148942.3
NR_148940.3
XM_047448649.1 XP_047304605.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1
XM_047448650.1 XP_047304606.1 RAF proto-oncogene serine/threonine-protein kinase isoform X1
NM_001354692.3 NP_001341621.1 RAF proto-oncogene serine/threonine-protein kinase isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23509299 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17979178 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7644510 GOA
enables protein kinase activity EXP
EXP: Inferred from Experiment
9446616 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
19667065 GOA
NOT enables small GTPase binding IPI
IPI: Inferred from physical interaction
12194967 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
15385642 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
19667065 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
9765203 GOA
involved in negative regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
19667065 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
10644344 GOA
involved in positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
19667065 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IPI
IPI: Inferred from physical interaction
17724343 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17724343 GOA
located in cytosol IDA
IDA: Inferred from direct assay
16009725 GOA
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
16009725 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17724343 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAF1 Protein Structure

RBD

RBD: Raf-like Ras-binding domain (56 - 130)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (139 - 185)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (351 - 605)

  • 0
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  • 500
  • 600
  • 648 a.a.
Protein Preferred Names Protein Names

RAF proto-oncogene serine/threonine-protein kinase

C-Raf proto-oncogene, serine/threonine kinase

Oncogene RAF1

proto-oncogene c-RAF

raf proto-oncogene serine/threonine protein kinase

v-raf-1 murine leukemia viral oncogene homolog 1

v-raf-1 murine leukemia viral oncogene-like protein 1

RAF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RAF1 P04049 PAK2 Homo sapiens Q13177
Protein Kinase Assay
16837009
Intra RAF1 P04049 PAK2 Homo sapiens Q13177
NMR
16837009
Intra RAF1 P04049 MLF2 Homo sapiens Q15773
Anti Tag CoIP
37045861
Intra RAF1 P04049 MAP2K2 Homo sapiens P36507
Y2H
21988832
Intra RAF1 P04049 PPP2R5C Homo sapiens Q13362
Phosphatase Assay
16239230
Intra RAF1 P04049 PPP2R5C Homo sapiens Q13362
Anti Tag CoIP
16239230
Cross RAF1 P04049 RAS2 Saccharomyces cerevisiae P01120
Pull Down
21457714
Intra RAF1 P04049 RCAN1 Homo sapiens P53805-2
Pull Down
15935327
Intra RAF1 P04049 PAQR3 Homo sapiens Q6TCH7
Anti Tag CoIP
17724343
Intra RAF1 P04049 CDC37 Homo sapiens Q16543
Anti Tag CoIP
37045861
Intra RAF1 P04049 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra RAF1 P04049 CDC37 Homo sapiens Q16543
Anti Tag CoIP
31980649
Intra RAF1 P04049 CDC37 Homo sapiens Q16543
TAP
17979178
Intra RAF1 P04049 HSP90AA1 Homo sapiens P07900
Pull Down
32707033
Intra RAF1 P04049 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
31980649
Intra RAF1 P04049 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
37045861
Intra RAF1 P04049 YWHAH Homo sapiens Q04917
Anti Tag CoIP
37045861
Intra RAF1 P04049 YWHAH Homo sapiens Q04917
Anti Tag CoIP
31980649
Intra RAF1 P04049 YWHAH Homo sapiens Q04917
Anti Tag CoIP
25852190
Intra RAF1 P04049 YWHAH Homo sapiens Q04917
Anti Tag CoIP
26496610
Intra RAF1 P04049 YWHAH Homo sapiens Q04917
TAP
17979178
Intra RAF1 P04049 YWHAH Homo sapiens Q04917
Pull Down
32707033
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Anti Tag CoIP
37045861
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Peptide Array
8601312
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Y2H
8085158
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Pull Down
7939632
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Pull Down
10887173
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Anti Tag CoIP
31980649
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
TAP
17979178
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Biochemical
11697890
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Pull Down
32707033
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Anti Tag CoIP
35271311
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Pull Down
16306228
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
Anti Tag CoIP
25852190
Intra RAF1 P04049 YWHAZ Homo sapiens P63104
CoIP
20052757
Intra RAF1 P04049 HRAS Homo sapiens P01112
FRET
18273062
Intra RAF1 P04049 HRAS Homo sapiens P01112
GMS
18073111
Intra RAF1 P04049 HRAS Homo sapiens P01112
Anti Tag CoIP
19063885
Intra RAF1 P04049 HRAS Homo sapiens P01112
Y2H
12620389
Intra RAF1 P04049 HRAS Homo sapiens P01112
Y2H
19696784
Intra RAF1 P04049 HRAS Homo sapiens P01112
Pull Down
20178605
Intra RAF1 P04049 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
Intra RAF1 P04049 HSP90AB1 Homo sapiens P08238
TAP
17979178
Intra RAF1 P04049 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra RAF1 P04049 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra RAF1 P04049 HSP90AB1 Homo sapiens P08238
Anti Bait CoIP
16330544
Intra RAF1 P04049 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
37045861
Intra RAF1 P04049 PKM Homo sapiens P14618
Y2H
12620389
Intra RAF1 P04049 HSPA5 Homo sapiens P11021
Anti Bait CoIP
18064632
Intra RAF1 P04049 TIMM50 Homo sapiens Q3ZCQ8
Anti Tag CoIP
31980649
Intra RAF1 P04049 TIMM50 Homo sapiens Q3ZCQ8
Anti Tag CoIP
37045861
Intra RAF1 P04049 TIMM50 Homo sapiens Q3ZCQ8
Anti Tag CoIP
25852190
Intra RAF1 P04049 TIMM50 Homo sapiens Q3ZCQ8
Y2H
12620389
Intra RAF1 P04049 BAG2 Homo sapiens O95816
Anti Tag CoIP
37045861
Intra RAF1 P04049 BAG2 Homo sapiens O95816
Lumier
25036637
Intra RAF1 P04049 BAG2 Homo sapiens O95816
Anti Tag CoIP
31980649
Intra RAF1 P04049 YWHAE Homo sapiens P62258
Anti Tag CoIP
31980649
Intra RAF1 P04049 YWHAE Homo sapiens P62258
Pull Down
32707033
Intra RAF1 P04049 YWHAE Homo sapiens P62258
Anti Tag CoIP
35271311
Intra RAF1 P04049 YWHAE Homo sapiens P62258
Anti Tag CoIP
37045861
Intra RAF1 P04049 YWHAE Homo sapiens P62258
Anti Tag CoIP
25852190
Intra RAF1 P04049 CCT3 Homo sapiens P49368
Anti Tag CoIP
37045861
Intra RAF1 P04049 CCT3 Homo sapiens P49368
Y2H
12620389
Intra RAF1 P04049 CCT3 Homo sapiens P49368
Anti Tag CoIP
31980649
Intra RAF1 P04049 STUB1 Homo sapiens Q9UNE7
Anti Tag CoIP
37045861
Intra RAF1 P04049 YWHAB Homo sapiens P31946
Anti Tag CoIP
31980649
Intra RAF1 P04049 YWHAB Homo sapiens P31946
Pull Down
32707033
Intra RAF1 P04049 YWHAB Homo sapiens P31946
Anti Tag CoIP
37045861
Intra RAF1 P04049 YWHAB Homo sapiens P31946
Anti Tag CoIP
35271311
Intra RAF1 P04049 YWHAB Homo sapiens P31946
Y2H
12620389
Intra RAF1 P04049 YWHAB Homo sapiens P31946
Anti Bait CoIP
7644510
Intra RAF1 P04049 YWHAB Homo sapiens P31946
Anti Tag CoIP
25852190
Intra RAF1 P04049 YWHAG Homo sapiens P61981
Anti Tag CoIP
31980649
Intra RAF1 P04049 YWHAG Homo sapiens P61981
Biochemical
11697890
Intra RAF1 P04049 YWHAG Homo sapiens P61981
Anti Tag CoIP
25852190
Intra RAF1 P04049 YWHAG Homo sapiens P61981
Pull Down
32707033
Intra RAF1 P04049 YWHAG Homo sapiens P61981
Anti Tag CoIP
37045861
Intra RAF1 P04049 YWHAQ Homo sapiens P27348
Anti Tag CoIP
31980649
Intra RAF1 P04049 YWHAQ Homo sapiens P27348
Pull Down
32707033
Intra RAF1 P04049 YWHAQ Homo sapiens P27348
Pull Down
7760835
Intra RAF1 P04049 YWHAQ Homo sapiens P27348
Biochemical
11697890
Intra RAF1 P04049 YWHAQ Homo sapiens P27348
Anti Tag CoIP
25852190
Intra RAF1 P04049 YWHAQ Homo sapiens P27348
Anti Tag CoIP
37045861
Intra RAF1 P04049 KRAS Homo sapiens P01116
Anti Tag CoIP
31980649
Intra RAF1 P04049 KRAS Homo sapiens P01116
Anti Tag CoIP
25852190
Intra RAF1 P04049 KRAS Homo sapiens P01116-2
Pull Down
20802526
Intra RAF1 P04049 KRAS Homo sapiens P01116-2
FRET
20080631
Intra RAF1 P04049 KRAS Homo sapiens P01116-2
Anti Tag CoIP
20802526
Intra RAF1 P04049 SFN Homo sapiens P31947
Anti Tag CoIP
25852190
Intra RAF1 P04049 SFN Homo sapiens P31947
Anti Tag CoIP
31980649
Intra RAF1 P04049 KSR1 Homo sapiens Q8IVT5
Anti Tag CoIP
37045861
Intra RAF1 P04049 KSR1 Homo sapiens Q8IVT5
Anti Bait CoIP
24929361
Intra RAF1 P04049 RB1 Homo sapiens P06400
Anti Bait CoIP
21139044
Intra RAF1 P04049 RAP1A Homo sapiens P62834
X-Ray Diffraction
7791872
Intra RAF1 P04049 NFATC3 Homo sapiens Q12968
Anti Bait CoIP
24330068
Intra RAF1 P04049 CPS1 Homo sapiens P31327
Y2H
12620389
Intra RAF1 P04049 OIP5 Homo sapiens O43482
Y2H
12620389
Cross RAF1 P04049 Lox Mus musculus P28301
Pull Down
21536655
Cross RAF1 P04049 Kras Mus musculus P32883
Pull Down
19164755
Cross RAF1 P04049 NS5A Hepacivirus hominis O39474
Anti Bait CoIP
16405965
Intra RAF1 P04049 PIN1 Homo sapiens Q13526
Anti Tag CoIP
20179161
Intra RAF1 P04049 PEBP1 Homo sapiens P30086
Anti Bait CoIP
17097642
Intra RAF1 P04049 PEBP1 Homo sapiens P30086
Peptide Array
17097642
Intra RAF1 P04049 PEBP1 Homo sapiens P30086
SPR
17097642
Intra RAF1 P04049 PEBP1 Homo sapiens P30086
Anti Tag CoIP
17097642
Intra RAF1 P04049 NRAS Homo sapiens P01111
Y2H Prey Pooling
32296183
Intra RAF1 P04049 NRAS Homo sapiens P01111
Pull Down
18641128
Intra RAF1 P04049 NRAS Homo sapiens P01111
Anti Tag CoIP
31980649
Intra RAF1 P04049 NRAS Homo sapiens P01111
FRET
20080631
Intra RAF1 P04049 NRAS Homo sapiens P01111
Y2H Array
32296183
Intra RAF1 P04049 CDC25A Homo sapiens P30304
Anti Bait CoIP
7644510
Intra RAF1 P04049 APP Homo sapiens P05067
Validated Y2H
32814053
Intra RAF1 P04049 APP Homo sapiens P05067
Y2H Array
32814053
Intra RAF1 P04049 APP Homo sapiens P05067
Y2H Pooling
32814053
Intra RAF1 P04049 CASP8 Homo sapiens Q14790
Y2H Pooling
32814053
Intra RAF1 P04049 CASP8 Homo sapiens Q14790
Validated Y2H
32814053
Intra RAF1 P04049 CASP8 Homo sapiens Q14790
Y2H Array
32814053
Intra RAF1 P04049 PEBP4 Homo sapiens Q96S96
Pull Down
19197339
Intra RAF1 P04049 STK3 Homo sapiens Q13188
Pull Down
24929361
Intra RAF1 P04049 STK3 Homo sapiens Q13188
Peptide Array
24929361
Intra RAF1 P04049 STK3 Homo sapiens Q13188
Anti Tag CoIP
24929361
Intra RAF1 P04049 STK3 Homo sapiens Q13188
Anti Bait CoIP
24929361
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cardiofaciocutaneous Syndrome 1

Cardiofaciocutaneous Syndrome

Cfc Syndrome

Cardio-Facio-Cutaneous Syndrome

CFC1

Cfcs

Cardio-Facial-Cutaneous Syndrome

Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

Cardiofaciocutaneous Syndrome, Type 1

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma

Pancreatic Adenocarcinoma

Adenocarcinoma Of Pancreas

Adenocarcinoma Of The Pancreas

Pancreas Adenocarcinoma

Malignant Exocrine Neoplasm

Primary Pancreatic Adenocarcinoma

Adenocarcinoma Of Islet Cell Of Pancreas

Islet Cell Adenocarcinoma Of Unspecified Site

Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma

Familial Medullary Thyroid Carcinoma

MTC

Fmtc

Mtc1

Thyroid Cancer, Medullary

Medullary Thyroid Cancer

Thyroid Carcinoma, Medullary

Familial Mtc

Thyroid Carcinoma Medullary

Carcinoma, Thyroid, Medullary, Familial

Medullary Carcinoma Of Thyroid

Medullary Carcinoma With Amyloid Stroma, Unspecified Site

Medullary Carcinoma With Amyloid Stroma Of Thyroid

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category

Retinitis Pigmentosa 74

RP74

Retinitis Pigmentosa, Type 74

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach

Stomach Adenocarcinoma

Adenocarcinoma Gastric

Intestinal Type Adenocarcinoma Of Unspecified Site

Diffuse Type Adenocarcinoma Of Unspecified Site

Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Noonan Syndrome 5

NS5

Noonan Syndrome, Type 5

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma

Grade I Astrocytic Tumor

Piloid Astrocytoma

Leopard Syndrome 2

LPRD2

Noonan Syndrome With Multiple Lentigines 2

Leopard Syndrome, Type 2

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy

Familial Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy 1

CMH1

Hypertrophic Cardiomyopathy 19

CMH

Ventricular Hypertrophy, Hereditary

Ash

Hypertrophic Subaortic Stenosis, Idiopathic

Cardiomyopathy, Familial Hypertrophic

Cardiomyopathy, Hypertrophic, 1, Digenic

Cardiomyopathy, Familial Hypertrophic 1

Hcm

Hereditary Ventricular Hypertrophy

Hypertrophic Cardiomyopathy

Cardiomyopathy, Hypertrophic, 1

Familial Asymmetric Septal Hypertrophy

Heritable Hypertrophic Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Fhc

Cardiomyopathy, Hypertrophic, Familial, Type 1

Cardiomyopathy, Hypertrophic, Familial

Cardiomyopathy, Dilated, 1nn

CMD1NN

Dilated Cardiomyopathy 1nn

Cardiomyopathy, Dilated 1nn

Cardiomyopathy, Dilated, Type 1nn

Noonan Syndrome And Noonan-Related Syndrome
Lung Adenoma

Adenoma Of Lung

Pulmonary Adenoma

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Chlamydia

Chlamydial Infection

Chlamydia Trachomatis Infectious Disease

Chlamydial Disease

Chlamydia Infections

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

CMM1

Melanoma, Cutaneous Malignant

Cmm

Melanoma, Malignant

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Neuroendocrine Tumor

Neuroendocrine Neoplasm

Neuroendocrine Tumors

Carcinoma, Neuroendocrine

Neurofibromatosis, Type I

Von Recklinghausen Disease

Neurofibromatosis 1

Neurofibromatosis, Type 1

NF1

Neurofibromatosis, Peripheral Type

Neurofibromatosis Type I

Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

Familial Spinal Neurofibromatosis

Fsnf

Peripheral Neurofibromatosis

Von Recklinghausen'S Neurofibromatosis

Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

Neurofibromatosis Peripheral Type

Von Recklinghausen Syndrome

Neurofibromatosis Type 1

Von Recklinghausen Neuropathy

Nf1 - [Neurofibromatosis Type 1]

Recklinghausen Disease

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Adenoid Cystic Carcinoma

Adenocystic Carcinoma

Cribriform Carcinoma

Cylindroma

Carcinoma Adenoid Cystic

Carcinoma, Adenoid Cystic

Adenoid Cystic Carcinoma Of Salivary Gland

Eccrine Dermal Cylindroma

Carcinoma, Cribriform

Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Pulmonic Stenosis

Congenital Pulmonary Valvar Stenosis

Congenital Stenosis Of Pulmonary Valve

Valvular Pulmonic Stenosis

Pulmonary Valve Stenosis

Pulmonary Stenosis

Congenital Pulmonary Valve Stricture

Congenital Pulmonary Valve Stenosis

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Lentigines

Lentigo

Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma

Noonan Syndrome 3

NS3

Noonan Syndrome, Type 3

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy, Hypertrophic, Familial

Familial Hypertrophic Cardiomyopathy

Cardiomyopathy Hypertrophic Obstructive

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Melanoma In Congenital Melanocytic Nevus

Malignant Melanoma In Congenital Melanocytic Nevus

Melanocytic Nevi

Nevi Melanocytic

Erythrocytosis, Familial, 3

ECYT3

Familial Erythrocytosis 3

Erythrocytosis, Familial, Type 3

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary

Skin Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Skin

Epidermoid Skin Carcinoma

Squamous Cell Carcinoma Of The Skin

Squamous Cell Epithelioma Of Skin

Cutaneous Squamous Cell Carcinoma

Scc - [Squamous Cell Carcinoma] Of Skin

Respiratory System Benign Neoplasm
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Larynx

Squamous Cell Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Head And Neck

Pseudo-Turner Syndrome

Noonan Syndrome

Kidney Cancer

Renal Cancer

Renal Carcinoma

Kidney Neoplasm

Malignant Neoplasm Of Kidney Except Pelvis

Malignant Tumour Of Kidney

Kidney Neoplasms

Cancer, Kidney

Cancer, Renal

Malignant Neoplasm Of Kidney

Renal Cell Carcinoma

Skin Melanoma

Cutaneous Melanoma

Malignant Ear Melanoma

Malignant Lip Melanoma

Malignant Lower Limb Melanoma

Malignant Melanoma Of Ear And/Or External Auricular Canal

Malignant Melanoma Of Skin Of Lower Limb

Malignant Melanoma Of Skin Of Trunk Except Scrotum

Malignant Melanoma Of Skin Of Upper Limb

Malignant Neck Melanoma

Malignant Scalp Melanoma

Malignant Trunk Melanoma

Malignant Upper Limb Melanoma

Melanoma, Cutaneous Malignant

Melanoma

Malignant Melanoma Of Skin

Melanoma Nos

Malignant Mole, Meaning Melanoma Of Unspecified Site

Melanoma Of Unspecified Site

Cutaneous Malignant Melanoma

Mm - [Malignant Melanoma]

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Costello Syndrome

Faciocutaneoskeletal Syndrome

Fcs Syndrome

Congenital Myopathy With Excess Of Muscle Spindles

CSTLO

CMEMS

Fcss

Myopathy, Congenital, With Excess Of Muscle Spindles

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Pilomyxoid Astrocytoma
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Acneiform Dermatitis

Dermatitis Acneiform

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus RAF1 MGD MGI:97847
Rattus norvegicus RAF1 RGD RGD:3531
Felis catus RAF1 VGNC VGNC:69220
Canis familiaris RAF1 VGNC VGNC:45325
Macaca mulatta RAF1 VGNC VGNC:76649
Others RAF1 NCBI