1. Gene
  2. ZFP91 - ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Gene

ZFP91 - ZFP91 zinc finger protein, atypical E3 ubiquitin ligase Gene

Homo sapiens

Also known as PZF; DSM8; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757

Gene ID: 80829 | Gene type: protein coding

About ZFP91

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:58,579,063-58,621,550 (from NCBI)

This gene has 1 transcript (splice variant), 235 orthologues and 36 paralogues. Broad expression in testis (RPKM 63.1), bone marrow (RPKM 24.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

ZFP91 Products(2)

mRNA Protein Name
NM_001197051.2 NP_001183980.1 E3 ubiquitin-protein ligase ZFP91 isoform 2
NM_053023.5 NP_444251.1 E3 ubiquitin-protein ligase ZFP91 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20682767 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of NF-kappaB-inducing kinase activity IDA
IDA: Inferred from direct assay
20682767 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
20682767 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFP91 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (386 - 409)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (430 - 453)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 570 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase ZFP91

RING-type E3 ubiquitin transferase ZFP91

ZFP91 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZFP91 Q96JP5 UBE2I Homo sapiens Q7KZS0 32296183
Intra
ZFP91 Q96JP5 UBE2I Homo sapiens Q7KZS0 32296183
Intra
ZFP91 Q96JP5 UBE2I Homo sapiens Q7KZS0 32296183
Intra
ZFP91 Q96JP5 ZNF526 Homo sapiens Q8TF50 32296183
Intra
ZFP91 Q96JP5 ZNF526 Homo sapiens Q8TF50 32296183
Intra
ZFP91 Q96JP5 ZNF526 Homo sapiens Q8TF50 32296183
Intra
ZFP91 Q96JP5 TP53BP2 Homo sapiens Q05BL1 32296183
Intra
ZFP91 Q96JP5 TP53BP2 Homo sapiens Q05BL1 32296183
Intra
ZFP91 Q96JP5 TP53BP2 Homo sapiens Q05BL1 32296183
Intra
ZFP91 Q96JP5 POU6F2 Homo sapiens P78424 32296183
Intra
ZFP91 Q96JP5 POU6F2 Homo sapiens P78424 32296183
Intra
ZFP91 Q96JP5 POU6F2 Homo sapiens P78424 32296183
Intra
ZFP91 Q96JP5 ZFP41 Homo sapiens Q8N8Y5 32296183
Intra
ZFP91 Q96JP5 ZFP41 Homo sapiens Q8N8Y5 32296183
Intra
ZFP91 Q96JP5 ZFP41 Homo sapiens Q8N8Y5 32296183
Intra
ZFP91 Q96JP5 AGR2 Homo sapiens O95994 32296183
Intra
ZFP91 Q96JP5 AGR2 Homo sapiens O95994 32296183
Intra
ZFP91 Q96JP5 AGR2 Homo sapiens O95994 32296183
Intra
ZFP91 Q96JP5 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
ZFP91 Q96JP5 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
ZFP91 Q96JP5 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
ZFP91 Q96JP5 PICK1 Homo sapiens Q9NRD5 32296183
Intra
ZFP91 Q96JP5 PICK1 Homo sapiens Q9NRD5 32296183
Intra
ZFP91 Q96JP5 PICK1 Homo sapiens Q9NRD5 32296183
Intra
ZFP91 Q96JP5 FAM9A Homo sapiens Q8IZU1 32296183
Intra
ZFP91 Q96JP5 FAM9A Homo sapiens Q8IZU1 32296183
Intra
ZFP91 Q96JP5 FAM9A Homo sapiens Q8IZU1 32296183
Intra
ZFP91 Q96JP5 TSPYL2 Homo sapiens Q9H2G4 32296183
Intra
ZFP91 Q96JP5 TSPYL2 Homo sapiens Q9H2G4 32296183
Intra
ZFP91 Q96JP5 TSPYL2 Homo sapiens Q9H2G4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Duane-Radial Ray Syndrome

Okihiro Syndrome

DRRS

Dr Syndrome

Duane Anomaly With Radial Ray Abnormalities And Deafness

Acrorenoocular Syndrome

Acrorenocular Syndrome

Duane Anomaly With Radial Abnormalities And Deafness

Acro-Renal-Ocular Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus ZFP91 MGD MGI:104854
Rattus norvegicus ZFP91 RGD RGD:628736
Macaca mulatta ZFP91 VGNC VGNC:101428