NECTIN4 - nectin cell adhesion molecule 4 Gene

Homo sapiens

Also known as LNIR; PRR4; EDSS1; PVRL4; nectin-4

Gene ID: 81607 | Gene type: protein coding

About NECTIN4

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,070,998-161,089,558 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues, 14 paralogues and is associated with 3 phenotypes. Biased expression in skin (RPKM 30.6), esophagus (RPKM 23.7) and 7 other tissues.

Summary

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

NECTIN4 Products(1)

mRNA	Protein	Name
NM_030916.3	NP_112178.2	nectin-4 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22902367	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECTIN4 Protein Structure

V-set

C2-set_2

0
100
200
300
400
510 a.a.

Protein Preferred Names

Protein Names

nectin-4

Ig superfamily receptor LNIR

NECTIN4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NECTIN4	Q96NY8	NECTIN1	Homo sapiens	Q15223	Protein Array	21982860
Intra	NECTIN4	Q96NY8	NECTIN4	Homo sapiens	Q96NY8	SPR	22902367
Intra	NECTIN4	Q96NY8	NECTIN4	Homo sapiens	Q96NY8	X-Ray Diffraction	22902367
Intra	NECTIN4	Q96NY8	EIF2B3	Homo sapiens	Q9NR50	Anti Tag CoIP	33961781
Intra	NECTIN4	Q96NY8	EIF2B1	Homo sapiens	Q14232	Anti Tag CoIP	33961781
Cross	NECTIN4	Q96NY8	H	measles virus	Q786F2	SPR	22048310
Intra	NECTIN4	Q96NY8	EIF2B3	Homo sapiens	Q9NR50	Anti Tag CoIP	28514442
Intra	NECTIN4	Q96NY8	EIF2B1	Homo sapiens	Q14232	Anti Tag CoIP	28514442
Intra	NECTIN4	Q96NY8	EIF2B2	Homo sapiens	P49770	Anti Tag CoIP	33961781
Intra	NECTIN4	Q96NY8	EIF2B2	Homo sapiens	P49770	Anti Tag CoIP	28514442
Intra	NECTIN4	Q96NY8	NECTIN4	Homo sapiens	Q96NY8	Solution Sedimentation	22902367
Cross	NECTIN4	Q96NY8	H	measles virus	Q786F2	Far-WB	22048310
Intra	NECTIN4	Q96NY8	TIGIT	Homo sapiens	Q495A1	Protein Array	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NECTIN4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70616	Nectin-4 Protein, Human (HEK293, His)	Q96NY8-1 (G32-V351)	≥95%
HY-P72401	Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi)	Q96NY8-1 (G32-V351)	≥95%
HY-P78181	Nectin-4 Protein IgV domain, Human (Biotinylated, HEK293, His-Avi)	Q96NY8-1 (G32-L146)	≥95%
HY-P78373	Nectin-4 Protein, Human (HEK293, Fc)	Q96NY8-1 (G32-S349)	≥95%
HY-P78374	Nectin-4 Protein, Human (HEK293, His-Avi)	Q96NY8-1 (G32-V351)	≥95%
HY-P78375	Nectin-4 Protein, Human (IgV, HEK293, His-Avi)	Q96NY8-1 (G32-L146)	≥95%

Related Diseases

Diseases

Alias

Ectodermal Dysplasia-Syndactyly Syndrome 1

EDSS1	Ectodermal Dysplasia-Syndactyly Syndrome
Edss	Dysplasia, Ectodermal, Syndactyly Syndrome, Type 1

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7	Zlotogora-Ogur Syndrome
CLPED1	Ectodermal Dysplasia, Margarita Island Type
Ed4	Cleft Lip-Palate-Ectodermal Dysplasia Syndrome
Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome	Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate
Ectodermal Dysplasia 4	Ectodermal Dysplasia Margarita Type
Ectodermal Dysplasia, Type 4	Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly
Margarita Type Of Ectodermal Dysplasia	Zlotogora-Zilberman-Tenenbaum Syndrome
Ectd4	Ectodermal Dysplasia 4, Hair/Nail Type
EDMI	Ectodermal Dysplasia Type 4
Margarita Island Ectodermal Dysplasia	Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate
Non-Syndromic Orofacial Cleft 7	OFC7
Non-Syndromic Cleft Lip/Palate 7	Non-Syndromic Cleft Lip With Or Without Cleft Palate 7

Skin Angiosarcoma

Angiosarcoma Of Skin	Hemangiosarcoma Of The Skin
Haemangiosarcoma Of Skin	Lymphangiosarcoma Of Skin
Cutaneous Angiosarcoma	Malignant Haemangioendothelioma Of Skin

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Testicular Fibroma

Chromosome 2q35 Duplication Syndrome

Syndactyly	Syndactyly Type 1
Sdty1	Zygodactyly
Syndactyly, Type I	Sd1
Syndactyly, Type 1, With Or Without Craniosynostosis	Symphalangism
Non-Syndromic Syndactyly	Symphalangy
Webbing Of Digits	Syndactyly, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99016A	Enfortumab vedotin-ejfv	Inhibitor	99.28%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99016	Enfortumab	Inhibitor	99.90%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99016B	Enfortumab vedotin-ejfv (solution)	Inhibitor	99.78%	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147271	Mal-PEG8-Val-Ala-PAB-Exatecan	Inhibitor	99.48%	Unkown
HY-RS09177	NECTIN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990977	Bulumtatug		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NECTIN4	VGNC	VGNC:63766
Macaca mulatta	NECTIN4	VGNC	VGNC:106415
Bos taurus	NECTIN4	VGNC	VGNC:55633
Canis familiaris	NECTIN4	VGNC	VGNC:43719
Rattus norvegicus	NECTIN4	RGD	RGD:1559826
Mus musculus	NECTIN4	MGD	MGI:1918990
Others	NECTIN4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.