2. Gene
  3. VMP1 - vacuole membrane protein 1 Gene

VMP1 - vacuole membrane protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EPG3; TANGO5; TMEM49

Gene ID: 81671 | Gene type: protein coding

About VMP1

Cytogenetic location: 17q23.1 Genomic coordinates (GRCh38): 17:59,707,654-59,842,255 (from NCBI)

This gene has 17 transcripts (splice variants), 264 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 60.7), appendix (RPKM 49.2) and 25 other tissues.

Summary

This gene encodes a transmembrane protein that plays a key regulatory role in the process of Autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers Autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]

VMP1 Products(10)

mRNA Protein Name
NM_001329394.2 NP_001316323.1 vacuole membrane protein 1 isoform 1
NM_001329395.2 NP_001316324.1 vacuole membrane protein 1 isoform 2
NM_001329396.2 NP_001316325.1 vacuole membrane protein 1 isoform 3
NM_001329397.2 NP_001316326.1 vacuole membrane protein 1 isoform 4
NM_001329398.2 NP_001316327.1 vacuole membrane protein 1 isoform 5
NM_001329399.2 NP_001316328.1 vacuole membrane protein 1 isoform 6
NM_001329400.2 NP_001316329.1 vacuole membrane protein 1 isoform 7
NM_001329401.2 NP_001316330.1 vacuole membrane protein 1 isoform 8
NM_001329402.2 NP_001316331.1 vacuole membrane protein 1 isoform 9
NM_030938.5 NP_112200.2 vacuole membrane protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phospholipid scramblase activity IDA
IDA: Inferred from direct assay
33850023 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17724469 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
28890335 GOA
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
30093494 GOA
involved in autophagosome membrane docking IDA
IDA: Inferred from direct assay
28890335 GOA
involved in autophagy IDA
IDA: Inferred from direct assay
28890335 GOA
involved in cell junction assembly IMP
IMP: Inferred from mutant phenotype
17724469 GOA
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
17724469 GOA
involved in lipoprotein transport IMP
IMP: Inferred from mutant phenotype
31526472 GOA
involved in mitochondrion-endoplasmic reticulum membrane tethering IDA
IDA: Inferred from direct assay
28890335 GOA
involved in organelle localization by membrane tethering IDA
IDA: Inferred from direct assay
28890335 GOA
involved in positive regulation of ATPase-coupled calcium transmembrane transporter activity IDA
IDA: Inferred from direct assay
28890335 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17724469 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
28890335 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vacuole membrane protein 1

ectopic P-granules autophagy protein 3 homolog

VMP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra VMP1 Q96GC9 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra VMP1 Q96GC9 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra VMP1 Q96GC9 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra VMP1 Q96GC9 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra VMP1 Q96GC9 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra VMP1 Q96GC9 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra VMP1 Q96GC9 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra VMP1 Q96GC9 SLC39A9 Homo sapiens Q9NUM3
Y2H Prey Pooling
32296183
Intra VMP1 Q96GC9 SLC39A9 Homo sapiens Q9NUM3
Y2H Array
32296183
Intra VMP1 Q96GC9 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra VMP1 Q96GC9 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra VMP1 Q96GC9 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra VMP1 Q96GC9 BECN1 Homo sapiens Q14457
Anti Bait CoIP
23316280
Intra VMP1 Q96GC9 BECN1 Homo sapiens Q14457
Anti Tag CoIP
23316280
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pancreatitis

Mumps Pancreatitis
Acute Pancreatitis

Pancreatitis

Pancreatitis, Acute Necrotizing

Pancreatitis Nos

Acute Pancreas Inflammation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15665 VMP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus VMP1 RGD RGD:70367
Canis familiaris VMP1 VGNC VGNC:49873
Macaca mulatta VMP1 VGNC VGNC:104673
Mus musculus VMP1 MGD MGI:1923159
Bos taurus VMP1 VGNC VGNC:36806
Felis catus VMP1 VGNC VGNC:66951