2. Gene
  3. SLC39A9 - solute carrier family 39 member 9 Gene

SLC39A9 - solute carrier family 39 member 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ZIP9; ZIP-9

Gene ID: 55334 | Gene type: protein coding

About SLC39A9

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,398,384-69,462,390 (from NCBI)

This gene has 11 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in thyroid (RPKM 15.0), kidney (RPKM 14.8) and 25 other tissues.

Summary

Predicted to enable metal ion transmembrane transporter activity. Predicted to be involved in transmembrane transport and zinc ion transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC39A9 Products(6)

mRNA Protein Name
NM_001252148.2 NP_001239077.1 zinc transporter ZIP9 isoform 2
NM_001252150.2 NP_001239079.1 zinc transporter ZIP9 isoform 3
NM_001252151.2 NP_001239080.1 zinc transporter ZIP9 isoform 4
NM_001252152.2 NP_001239081.1 zinc transporter ZIP9 isoform 4
NM_001330185.2 NP_001317114.1 zinc transporter ZIP9 isoform 5
NM_018375.5 NP_060845.2 zinc transporter ZIP9 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
28219737 GOA
enables androgen binding IDA
IDA: Inferred from direct assay
28219737 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables zinc efflux transmembrane transporter activity IDA
IDA: Inferred from direct assay
19420709 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
28219737 GOA
enables zinc ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
25014355 GOA
Biological Process GO Annotation Evidence Reference Source
involved in intracellular zinc ion homeostasis IDA
IDA: Inferred from direct assay
19420709 GOA
involved in regulation of vascular endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
34555425 GOA
involved in zinc ion transmembrane transport IDA
IDA: Inferred from direct assay
25014355 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
25014355 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
34555425 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25014355 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
25014355 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
25014355 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
19420709 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A9 Protein Structure

Zip

Zip: ZIP Zinc transporter (131 - 301)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

zinc transporter ZIP9

ZRT/IRT-like protein 9

SLC39A9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC39A9 Q9NUM3 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 ELOVL5 Homo sapiens Q9NYP7
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 ELOVL5 Homo sapiens Q9NYP7
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 ELOVL5 Homo sapiens Q9NYP7
Validated Y2H
32296183
Intra
SLC39A9 Q9NUM3 LNPEP Homo sapiens Q9UIQ6-2
Validated Y2H
32296183
Intra
SLC39A9 Q9NUM3 SLC66A1 Homo sapiens Q6ZP29-3
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 SLC66A1 Homo sapiens Q6ZP29-3
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 GPR101 Homo sapiens Q96P66
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 GPR101 Homo sapiens Q96P66
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 TRHR Homo sapiens P34981
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 TRHR Homo sapiens P34981
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 CERS3 Homo sapiens Q8IU89
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 CERS3 Homo sapiens Q8IU89
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 CBARP Homo sapiens Q8N350-4
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 CBARP Homo sapiens Q8N350-4
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 APH1A Homo sapiens Q96BI3
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 APH1A Homo sapiens Q96BI3
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Intra
SLC39A9 Q9NUM3 HERPUD2 Homo sapiens Q9BSE4
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 HERPUD2 Homo sapiens Q9BSE4
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 MFSD5 Homo sapiens Q6N075
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 MFSD5 Homo sapiens Q6N075
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 CREB3L3 Homo sapiens Q68CJ9
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 CREB3L3 Homo sapiens Q68CJ9
Y2H Prey Pooling
32296183
Intra
SLC39A9 Q9NUM3 HTR2C Homo sapiens P28335
Y2H Array
32296183
Intra
SLC39A9 Q9NUM3 HTR2C Homo sapiens P28335
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13240 SLC39A9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC39A9 VGNC VGNC:34869
Mus musculus SLC39A9 MGD MGI:1914820
Rattus norvegicus SLC39A9 RGD RGD:1311236
Canis familiaris SLC39A9 VGNC VGNC:46408
Felis catus SLC39A9 VGNC VGNC:65364
Macaca mulatta SLC39A9 VGNC VGNC:77523