Ndel1 - nudE neurodevelopment protein 1 like 1 Gene

Mus musculus

Also known as NUDEL; MITAP1; mNudel; mNudE-L; 2600006O07Rik

Gene ID: 83431 | Gene type: protein coding

About Ndel1

Summary

Enables identical protein binding activity and tubulin binding activity. Involved in several processes, including Insulin Receptor signaling pathway; lysosome localization; and regulation of plasma membrane bounded cell projection organization. Acts upstream of or within several processes, including Cytoskeleton organization; generation of neurons; and transport along microtubule. Located in several cellular components, including axon hillock; cytoskeleton; and synaptic vesicle. Part of microtubule associated complex. Is expressed in several structures, including central nervous system; craniocervical region bone; integumental system; metanephros; and sensory organ. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Ndel1 Products(3)

mRNA	Protein	Name
NM_001363304.1	NP_001350233.1	nuclear distribution protein nudE-like 1 isoform 2
NM_001363305.1	NP_001350234.1	nuclear distribution protein nudE-like 1 isoform 3
NM_023668.3	NP_076157.2	nuclear distribution protein nudE-like 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	18331715	MGI
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	18331715	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	17997972	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	11163259	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11231056	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activation of GTPase activity	IDA IDA: Inferred from direct assay	18331715	MGI
NOT involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20624590	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	18331715	MGI
acts upstream of or within central nervous system neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	15208636	MGI
acts upstream of or within centrosome localization	IMP IMP: Inferred from mutant phenotype	18331715	MGI
involved in cerebral cortex radially oriented cell migration	IMP IMP: Inferred from mutant phenotype	20624590	MGI
acts upstream of or within inner cell mass cell proliferation	IMP IMP: Inferred from mutant phenotype	16107726	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	28057765	MGI
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	27777970	MGI
acts upstream of or within microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	16107726	MGI
acts upstream of or within mitotic centrosome separation	IGI IGI: Inferred from genetic interaction	17060449	MGI
acts upstream of or within mitotic centrosome separation	IMP IMP: Inferred from mutant phenotype	17060449	MGI
acts upstream of or within neurofilament cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15208636	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	16107726	MGI
acts upstream of or within neuron projection extension	IGI IGI: Inferred from genetic interaction	19668197	MGI
involved in positive regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	27777970	MGI
acts upstream of or within radial glia-guided pyramidal neuron migration	IGI IGI: Inferred from genetic interaction	16107726	MGI
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17825401	MGI
acts upstream of or within retrograde axonal transport	IDA IDA: Inferred from direct assay	11163259	MGI
acts upstream of or within vesicle transport along microtubule	IGI IGI: Inferred from genetic interaction	16107726	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16203747	MGI
located in axon hillock	IDA IDA: Inferred from direct assay	19668197	MGI
located in cell leading edge	IDA IDA: Inferred from direct assay	18331715	MGI
located in centrosome	IDA IDA: Inferred from direct assay	11163259	MGI
part of microtubule associated complex	IDA IDA: Inferred from direct assay	11163259	MGI
located in microtubule organizing center	IGI IGI: Inferred from genetic interaction	19668197	MGI
located in neurofilament cytoskeleton	IDA IDA: Inferred from direct assay	15208636	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	18983980	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear distribution protein nudE-like 1

nuclear disribution gene E like	nuclear distribution gene E-like homolog 1
protein Nudel

Ndel1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ndel1	Q9ERR1	Ywhae	Mus musculus	P62259	Pull Down	12796778
Intra	Ndel1	Q9ERR1	Ywhae	Mus musculus	P62259	Anti Bait CoIP	12796778
Intra	Ndel1	Q9ERR1	PAFAH1B1	Homo sapiens	P43034	Anti Tag CoIP	26496610
Intra	Ndel1	Q9ERR1	Pafah1b1	Mus musculus	P63005	Y2H	11231056
Intra	Ndel1	Q9ERR1	Pafah1b1	Mus musculus	P63005	Anti Bait CoIP	12796778
Intra	Ndel1	Q9ERR1	Pafah1b1	Mus musculus	P63005	Pull Down	11231056
Intra	Ndel1	Q9ERR1	Ndel1	Mus musculus	Q9ERR1	X-Ray Diffraction	17997972
Intra	Ndel1	Q9ERR1	PAFAH1B1	Homo sapiens	P43034	Anti Bait CoIP	19927128
Intra	Ndel1	Q9ERR1	Ndel1	Mus musculus	Q9ERR1	Solution Sedimentation	17997972
Intra	Ndel1	Q9ERR1	Ndel1	Mus musculus	Q9ERR1	CD	17997972
Intra	Ndel1	Q9ERR1	Pafah1b1	Mus musculus	P63005	Pull Down	17997972
Intra	Ndel1	Q9ERR1	Pafah1b1	Mus musculus	P63005	EPR	17997972

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09107	NDEL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ndel1	NCBI	NCBI:81565

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