NUF2 - NUF2 component of NDC80 kinetochore complex Gene

Homo sapiens

Also known as CDCA1; CT106; NUF2R

Gene ID: 83540 | Gene type: protein coding

About NUF2

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:163,321,954-163,355,759 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 1 paralogue. Biased expression in testis (RPKM 23.0), bone marrow (RPKM 9.4) and 11 other tissues.

Summary

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

NUF2 Products(2)

mRNA	Protein	Name
NM_031423.4	NP_113611.2	kinetochore protein Nuf2
NM_145697.3	NP_663735.2	kinetochore protein Nuf2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	18455984	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14699129	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in attachment of spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	18455984	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ndc80 complex	IDA IDA: Inferred from direct assay	14699129	GOA
part of Ndc80 complex	IPI IPI: Inferred from physical interaction	18455984	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	15961401	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	24530301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUF2 Protein Structure

Nuf2

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

kinetochore protein Nuf2

NDC80 kinetochore complex component NUF2

NUF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUF2	Q9BZD4	EXOC1	Homo sapiens	Q9NV70	Y2H	17043677
Intra	NUF2	Q9BZD4	CENPE	Homo sapiens	Q02224	IF	17535814
Intra	NUF2	Q9BZD4	CENPE	Homo sapiens	Q02224	Anti Bait CoIP	17535814
Intra	NUF2	Q9BZD4	CENPE	Homo sapiens	Q02224	Pull Down	17535814
Intra	NUF2	Q9BZD4	CENPE	Homo sapiens	Q02224	Anti Tag CoIP	17535814
Intra	NUF2	Q9BZD4	CENPE	Homo sapiens	Q02224	Y2H	17535814
Intra	NUF2	Q9BZD4	NDC80	Homo sapiens	O14777	MAPPIT	25416956
Intra	NUF2	Q9BZD4	NDC80	Homo sapiens	O14777	Pull Down	15961401
Intra	NUF2	Q9BZD4	NDC80	Homo sapiens	O14777	Anti Tag CoIP	35271311
Intra	NUF2	Q9BZD4	NDC80	Homo sapiens	O14777	Anti Tag CoIP	26496610
Intra	NUF2	Q9BZD4	NDC80	Homo sapiens	O14777	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

NUF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81710	Nuf2 Antibody (YA1455)	WB	Human

Related Diseases

Diseases

Alias

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09676	NUF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NUF2	VGNC	VGNC:75405
Canis familiaris	NUF2	VGNC	VGNC:44038
Bos taurus	NUF2	VGNC	VGNC:32344
Felis catus	NUF2	VGNC	VGNC:63916
Mus musculus	NUF2	MGD	MGI:1914227
Rattus norvegicus	NUF2	RGD	RGD:1307952

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