1. Gene
  2. Rps6kb1 - ribosomal protein S6 kinase B1 Gene

Rps6kb1 - ribosomal protein S6 kinase B1 Gene

Rattus norvegicus

Also known as p70 S6K-alpha

Gene ID: 83840 | Gene type: protein coding

About Rps6kb1

Primary_assembly 10: 71,323,777-71,367,908 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 155 orthologues, 7 paralogues and is associated with 17 phenotypes. Biased expression in Muscle (RPKM 16.2), Thymus (RPKM 146.) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; PDZ domain binding activity; and protein Phosphatase 2A binding activity. Involved in several processes, including long-term memory; positive regulation of skeletal muscle tissue growth; and response to peptide hormone. Located in several cellular components, including cell surface; cytosol; and perinuclear region of cytoplasm. Is active in synapse. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hyperinsulinism; muscular atrophy; obesity; and primary biliary cholangitis. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Apr 2022]

Rps6kb1 Products(1)

mRNA Protein Name
NM_031985.1 NP_114191.1 ribosomal protein S6 kinase beta-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
11574531 RGD
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
9653190 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
17446865 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
11574531 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9653190 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
11574531 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
16899564 RGD
enables ribosomal protein S6 kinase activity IMP
IMP: Inferred from mutant phenotype
11574531 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IEP
IEP: Inferred from expression pattern
16710051 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
16717100 RGD
involved in long-term memory IEP
IEP: Inferred from expression pattern
16885218 RGD
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18952604 RGD
involved in positive regulation of skeletal muscle tissue growth IMP
IMP: Inferred from mutant phenotype
16408196 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
16148030 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16148030 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11574531 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
9653190 RGD
involved in regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
18952604 RGD
involved in response to L-leucine IEP
IEP: Inferred from expression pattern
16616211 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
10913029 RGD
involved in response to electrical stimulus involved in regulation of muscle adaptation IEP
IEP: Inferred from expression pattern
15716393 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
15547464 RGD
involved in response to glucagon IEP
IEP: Inferred from expression pattern
15494402 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
14630710 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
16885218 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
15908181 RGD
involved in response to insulin IMP
IMP: Inferred from mutant phenotype
18952604 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
15389631 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17526558 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
10913029 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16616211 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
12668683 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
15698549 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
15342961 RGD
involved in response to tumor necrosis factor IMP
IMP: Inferred from mutant phenotype
18952604 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17728140 RGD
involved in skeletal muscle atrophy IEP
IEP: Inferred from expression pattern
17885021 RGD
involved in skeletal muscle contraction IEP
IEP: Inferred from expression pattern
15033970 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
16710051 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16710051 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
14623952 RGD
is active in synapse IDA
IDA: Inferred from direct assay
12711090 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6kb1 Protein Structure

STKc_p70S6K

STKc_p70S6K: cd05584 (93 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase beta-1

70 kDa ribosomal protein S6 kinase 1

P70S6K

P70S6K1

S6 kinase

S6K

S6K-beta-1

S6K1

p70 S6 kinase alpha

p70 S6KA

p70 ribosomal S6 kinase alpha

p70(S6K)-alpha

p70-S6K 1

ribosomal protein S6 kinase I

ribosomal protein S6 kinase, 70kDa, polypeptide 1

ribosomal protein S6 kinase, polypeptide 1

Rps6kb1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Rps6kb1 P67999 RPTOR Homo sapiens Q8N122
Pull Down
12150926
Intra
Rps6kb1 P67999 Ppp1r9a Rattus norvegicus O35867
Pull Down
9653190
Intra
Rps6kb1 P67999 Pdk1 Rattus norvegicus Q63065
Protein Kinase Assay
17446865
Intra
Rps6kb1 P67999 Rps6kb1 Rattus norvegicus P67999
Protein Kinase Assay
17446865
Intra
Rps6kb1 P67999 Rps6 Mus musculus P62754
Protein Kinase Assay
21986499
Intra
Rps6kb1 P67999 Mtor Mus musculus Q9JLN9
Protein Kinase Assay
12150926
Intra
Rps6kb1 P67999 Ppp1r9a Rattus norvegicus O35867
Anti Tag CoIP
9653190
Intra
Rps6kb1 P67999 Coasy Rattus norvegicus Q5XIA5
GMS
15589845
Intra
Rps6kb1 P67999 Rps6kb1 Rattus norvegicus P67999
Protein Kinase Assay
21986499
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Rps6kb1 NCBI NCBI:6198