Mtor - mechanistic target of rapamycin kinase Gene

Mus musculus

Also known as FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; 2610315D21Rik

Gene ID: 56717 | Gene type: protein coding

About Mtor

Chromosome 4: 148,533,068-148,642,140 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 64 phenotypes. Ubiquitous expression in testis adult (RPKM 23.), kidney adult (RPKM 12.8) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human mTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mtor Products(1)

mRNA	Protein	Name
NM_020009.2	NP_064393.2	serine/threonine-protein kinase mTOR

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12150926	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11707573	MGI
enables ribosome binding	IDA IDA: Inferred from direct assay	21045808	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in 'de novo' pyrimidine nucleobase biosynthetic process	IDA IDA: Inferred from direct assay	23429704	MGI
involved in T-helper 1 cell lineage commitment	IMP IMP: Inferred from mutant phenotype	26410627	MGI
involved in TOR signaling	IGI IGI: Inferred from genetic interaction	26160071	MGI
involved in TOR signaling	IMP IMP: Inferred from mutant phenotype	15485918	MGI
involved in behavioral response to pain	IGI IGI: Inferred from genetic interaction	31874168	MGI
acts upstream of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	18347059	MGI
involved in cardiac cell development	IMP IMP: Inferred from mutant phenotype	23342106	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within cell projection organization	IMP IMP: Inferred from mutant phenotype	16286931	MGI
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	16915281	MGI
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	21258367	MGI
acts upstream of or within energy reserve metabolic process	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within germ cell development	IDA IDA: Inferred from direct assay	12140361	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	25139234	MGI
involved in inflammatory response	IGI IGI: Inferred from genetic interaction	31874168	MGI
acts upstream of macroautophagy	IMP IMP: Inferred from mutant phenotype	16714284	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	25139234	MGI
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	21258367	MGI
acts upstream of or within negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	18347059	MGI
acts upstream of or within negative regulation of cell size	IGI IGI: Inferred from genetic interaction	15185396	MGI
acts upstream of or within negative regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	16714284	MGI
involved in neuronal action potential	IGI IGI: Inferred from genetic interaction	31874168	MGI
acts upstream of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	25411504	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	24011591	MGI
acts upstream of or within peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18347059	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	11707573	MGI
acts upstream of or within positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	15467718	MGI
acts upstream of or within positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	15467718	MGI
acts upstream of or within positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	15467718	MGI
acts upstream of or within positive regulation of myotube differentiation	IGI IGI: Inferred from genetic interaction	19704009	MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	25411504	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	15467718	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	15467718	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	15467718	MGI
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	24011591	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	29750810	MGI
involved in regulation of locomotor rhythm	IMP IMP: Inferred from mutant phenotype	29750810	MGI
acts upstream of or within regulation of membrane permeability	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within regulation of myelination	IMP IMP: Inferred from mutant phenotype	24101522	MGI
involved in regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	19440205	MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	25139234	MGI
acts upstream of or within regulation of protein kinase activity	IGI IGI: Inferred from genetic interaction	15185396	MGI
acts upstream of or within regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	17556672	MGI
acts upstream of or within response to amino acid	IDA IDA: Inferred from direct assay	15467718	MGI
involved in response to heat	IGI IGI: Inferred from genetic interaction	31874168	MGI
acts upstream of or within response to insulin	IDA IDA: Inferred from direct assay	15467718	MGI
acts upstream of or within ruffle organization	IDA IDA: Inferred from direct assay	15467718	MGI
acts upstream of or within voluntary musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	25139234	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with PML body	IDA IDA: Inferred from direct assay	16915281	MGI
part of TORC1 complex	IDA IDA: Inferred from direct assay	12718876	MGI
located in cytosol	IDA IDA: Inferred from direct assay	16915281	MGI
located in dendrite	IDA IDA: Inferred from direct assay	23836929	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18347059	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mtor Protein Structure

TEL1

HEAT

0
400
800
1200
1600
2000
2400
2549 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase mTOR

FK506 binding protein 12-rapamycin associated protein 1	FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP-rapamycin associated protein (FRAP)	FKBP12-rapamycin complex-associated protein
angiopoietin-like factor CDT6	mammalian target of rapamycin
mechanistic target of rapamycin (serine/threonine kinase)	rapamycin target protein 1

Mtor Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Mtor	Q9JLN9	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	24036451
Intra	Mtor	Q9JLN9	Eif3f	Mus musculus	Q9DCH4	Pull Down	16541103
Intra	Mtor	Q9JLN9	Rictor	Mus musculus	Q6QI06	Anti Bait CoIP	20801936
Intra	Mtor	Q9JLN9	Rictor	Mus musculus	Q6QI06	Anti Tag CoIP	18566586
Intra	Mtor	Q9JLN9	Rictor	Mus musculus	Q6QI06	Anti Bait CoIP	21045808
Intra	Mtor	Q9JLN9	Rictor	Mus musculus	Q6QI06	Density Sedimentation	21045808
Intra	Mtor	Q9JLN9	Rictor	Mus musculus	Q6QI06	Anti Bait CoIP	18664580
Intra	Mtor	Q9JLN9	Rptor	Mus musculus	Q8K4Q0	Anti Bait CoIP	21045808
Intra	Mtor	Q9JLN9	Rptor	Mus musculus	Q8K4Q0	Anti Tag CoIP	20801936
Intra	Mtor	Q9JLN9	Rptor	Mus musculus	Q8K4Q0	Anti Bait CoIP	23966835
Intra	Mtor	Q9JLN9	Rptor	Mus musculus	Q8K4Q0	Density Sedimentation	21045808
Intra	Mtor	Q9JLN9	Rptor	Mus musculus	Q8K4Q0	Anti Bait CoIP	18664580
Intra	Mtor	Q9JLN9	Rptor	Mus musculus	Q8K4Q0	Anti Bait CoIP	20801936

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10219	Rapamycin	Inhibitor	99.94%	Yes
HY-B0627	Metformin	Inhibitor	99.98%	Yes
HY-10218	Everolimus	Inhibitor	99.85%	Yes
HY-17471A	Metformin hydrochloride	Inhibitor	99.98%	Yes
HY-Y0252	L-Proline	Activator	≥98.0%	Unkown
HY-50910	Temsirolimus	Inhibitor	99.56%	Yes
HY-N0486	L-Leucine	Activator	99.79%	Unkown
HY-N0281	Daphnetin	Inhibitor	99.86%	Unkown
HY-B0766	Bicyclol		99.91%	Unkown
HY-B0319	Tioconazole	Inhibitor	99.90%	Unkown
HY-17471AR	Metformin (hydrochloride) (Standard)	Inhibitor	99.97%	Unkown
HY-B0725A	Doxepin		/	Unkown
HY-B1232A	Metyrapone Tartrate	Modulator	/	Unkown
HY-10218R	Everolimus (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (40)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10219G	Rapamycin (GMP)	Inhibitor	/	Phase 4
HY-B0627A	Metformin (glycinate)	Inhibitor	/	Phase 4
HY-50673	Dactolisib	Inhibitor	99.94%	Phase 3
HY-10681	Gedatolisib	Inhibitor	99.68%	Phase 3
HY-15174	Dactolisib Tosylate	Inhibitor	99.87%	Phase 3
HY-50908	Ridaforolimus	Inhibitor	99.75%	Phase 3
HY-139142B	Simufilam hydrochloride	Inhibitor	99.77%	Phase 3
HY-B1787	Sulindac sulfone	Inhibitor	98.10%	Phase 3
HY-13328	Sapanisertib	Inhibitor	99.66%	Phase 2
HY-139609	Camonsertib	Inhibitor	99.75%	Phase 2
HY-N0112	Dihydromyricetin	Inhibitor	98.10%	Phase 2
HY-114384	NV-5138	Activator	≥98.0%	Phase 2
HY-15247	Vistusertib	Inhibitor	99.32%	Phase 2
HY-19962	Paxalisib	Inhibitor	99.63%	Phase 2
HY-15177	PF-04691502	Inhibitor	99.91%	Phase 2
HY-12513	Samotolisib	Inhibitor	99.27%	Phase 2
HY-114384B	NV-5138 hydrochloride	Activator	≥98.0%	Phase 2
HY-13246	Apitolisib	Inhibitor	99.29%	Phase 2
HY-12868	Bimiralisib	Inhibitor	99.80%	Phase 2
HY-15900	Voxtalisib	Inhibitor	99.02%	Phase 2
HY-16956	Onatasertib	Inhibitor	99.13%	Phase 2
HY-13334A	BGT226	Inhibitor	99.51%	Phase 2
HY-N9481	Lipoteichoic acid	Inhibitor	/	Phase 2
HY-10423	OSI-027	Inhibitor	99.95%	Phase 2
HY-13334	BGT226 maleate	Inhibitor	99.92%	Phase 2
HY-13691	MKC-1	Inhibitor	99.78%	Phase 2
HY-10422	AZD-8055	Inhibitor	99.60%	Phase 1
HY-132168	RMC-5552	Inhibitor	98.10%	Phase 1
HY-10297	Omipalisib	Inhibitor	99.94%	Phase 1
HY-16962	CC-115	Inhibitor	99.82%	Phase 1
HY-12036	GSK1059615	Inhibitor	≥99.0%	Phase 1
HY-16585	VS-5584	Inhibitor	99.14%	Phase 1
HY-16962A	CC-115 hydrochloride	Inhibitor	98.03%	Phase 1
HY-14581	Palomid 529	Inhibitor	99.37%	Phase 1
HY-15248	GDC-0349	Inhibitor	98.02%	Phase 1
HY-126077	MTI-31	Inhibitor	99.98%	Phase 1
HY-11080	PKI-179	Inhibitor	≥98.0%	Phase 1
HY-137315	TML-6	Inhibitor	99.01%	Phase 1
HY-11080A	PKI-179 hydrochloride	Inhibitor	99.66%	Phase 1
HY-124036	DS-7423	Inhibitor	99.75%	Phase 1

Pre-clinical Phase

Bioactive Molecules (246)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0795	MHY1485	Activator	99.93%	Unkown
HY-13003	Torin 1	Inhibitor	99.28%	Unkown
HY-N0109	Salidroside	Activator	99.90%	Unkown
HY-13002	Torin 2	Inhibitor	99.65%	Unkown
HY-10115	PI-103	Inhibitor	99.82%	Unkown
HY-U00434	3BDO	Activator	99.93%	Unkown
HY-111373	RapaLink-1	Inhibitor	99.92%	Unkown
HY-122022	JR-AB2-011	Inhibitor	98.15%	Unkown
HY-10474	Torkinib	Inhibitor	99.03%	Unkown
HY-100542	D-α-Hydroxyglutaric acid disodium	Inhibitor	≥98.0%	Unkown
HY-N0189	Aloe emodin	Inhibitor	98.32%	Unkown
HY-124719	hSMG-1 inhibitor 11j	Inhibitor	99.82%	Unkown
HY-13610A	N1,N11-Diethylnorspermine tetrahydrochloride	Inhibitor	≥98.0%	Unkown
HY-N0270	Ononin	Inhibitor	99.96%	Unkown
HY-124798	Rheb inhibitor NR1	Inhibitor	99.03%	Unkown
HY-N0787	Cryptochlorogenic acid	Inhibitor	99.87%	Unkown
HY-W012722	4-Methyl-2-oxopentanoic acid	Inhibitor	99.51%	Unkown
HY-N0047	Polyphyllin I	Inhibitor	99.89%	Unkown
HY-50710	KU-0063794	Inhibitor	99.55%	Unkown
HY-N0022	Isoacteoside	Inhibitor	99.73%	Unkown
HY-155747	FDW028	Inhibitor	99.51%	Unkown
HY-116522	AR420626		98.29%	Unkown
HY-124760	hSMG-1 inhibitor 11e	Inhibitor	99.81%	Unkown
HY-134904	RMC-6272	Inhibitor	95.54%	Unkown
HY-N0486S1	L-Leucine-13C	Activator	99.4%	Unkown
HY-N0486S9	L-Leucine-d3	Activator	99.93%	Unkown
HY-N6602	α-Solanine	Inhibitor	99.89%	Unkown
HY-10044	WYE-132	Inhibitor	99.90%	Unkown
HY-D0195	Acesulfame potassium	Activator	99.38%	Unkown
HY-18353	mTOR inhibitor-3	Inhibitor	99.09%	Unkown
HY-N0447	8-Gingerol	Modulator	99.82%	Unkown
HY-10683	PKI-402	Inhibitor	98.43%	Unkown
HY-13431	KU-0060648	Inhibitor	99.62%	Unkown
HY-10372	PP121	Inhibitor	98.67%	Unkown
HY-115449	Chromeceptin	p53 Inhibitor	99.80%	Unkown
HY-N6626	Pyraclostrobin		99.91%	Unkown
HY-110228	Metformin-d6 hydrochloride	Inhibitor	98.79%	Unkown
HY-W142080	α-Methyl-DL-tryptophan	Inhibitor	99.92%	Unkown
HY-N6996	Methyl Eugenol	Inhibitor	99.79%	Unkown
HY-W592871	10-Hydroxy-2-decenoic acid		99.99%	Unkown
HY-12763	GNE-317	Inhibitor	99.14%	Unkown
HY-146751	PI3K/Akt/mTOR-IN-2	Inhibitor	99.93%	Unkown
HY-N1462	Atractyloside potassium salt	Inhibitor	99.93%	Unkown
HY-10115A	PI-103 Hydrochloride	Inhibitor	98.55%	Unkown
HY-100222	CZ415	Inhibitor	98.39%	Unkown
HY-107365	PQR530	Inhibitor	99.98%	Unkown
HY-N0656A	(+)-Usnic acid	Inhibitor	99.63%	Unkown
HY-N0107	Cyclovirobuxine D	Inhibitor	≥98.0%	Unkown
HY-N2541	Gymnemic acid I	Inhibitor	98.84%	Unkown
HY-15521	ETP-46464	Inhibitor	99.55%	Unkown
HY-156671	RMC-4998	Inhibitor	96.33%	Unkown
HY-N0486S8	L-Leucine-13C6,15N	Activator	99.90%	Unkown
HY-W016412	Coenzyme Q0	Inhibitor	99.88%	Unkown
HY-12808	STF-118804	Inhibitor	99.72%	Unkown
HY-100026	PQR620	Inhibitor	98.01%	Unkown
HY-12034	WYE-354	Inhibitor	98.04%	Unkown
HY-15272	WAY-600	Inhibitor	99.75%	Unkown
HY-112914	mTOR inhibitor-1	Inhibitor	98.82%	Unkown
HY-N6843	Arnicolide D	Inhibitor	99.69%	Unkown
HY-100398	PF-04979064	Inhibitor	99.54%	Unkown
HY-W130610	Stearamide	Activator	≥97.0%	Unkown
HY-10811	GNE-493	Inhibitor	99.81%	Unkown
HY-114414	HDACs/mTOR Inhibitor 1	Inhibitor	99.01%	Unkown
HY-159480	AD1058	Inhibitor	98.11%	Unkown
HY-N6950	Hederacolchiside A1	Modulator	≥99.0%	Unkown
HY-N0486S3	L-Leucine-15N	Activator	≥98.0%	Unkown
HY-10219S	Rapamycin-d3	Inhibitor	95.48%	Unkown
HY-100470	NSC781406	Inhibitor	99.97%	Unkown
HY-111508	PI3K/mTOR Inhibitor-2	Inhibitor	99.10%	Unkown
HY-131344	mTOR inhibitor-8	Inhibitor	98.14%	Unkown
HY-132902	DEPTOR-IN-1	Inhibitor	99.09%	Unkown
HY-N0486S	L-Leucine-d10	Activator	≥99.0%	Unkown
HY-W058849	MT 63-78	Inhibitor	98.50%	Unkown
HY-128333	PI3K/mTOR Inhibitor-4	Inhibitor	97.00%	Unkown
HY-118717	mTOR inhibitor WYE-28	Inhibitor	99.75%	Unkown
HY-11042	GNE-477	Inhibitor	98.75%	Unkown
HY-137175	TMBIM6 antagonist-1	Antagonist	99.60%	Unkown
HY-109046	Tulrampator		99.39%	Unkown
HY-N0486S2	L-Leucine-13C6	Activator	≥98.0%	Unkown
HY-110109	ETP-45658	Inhibitor	98.97%	Unkown
HY-136660	PQR626	Inhibitor	98.05%	Unkown
HY-151622	PI3K/mTOR Inhibitor-11	Inhibitor	98.74%	Unkown
HY-163199	ASCT2-IN-2	Inhibitor	99.10%	Unkown
HY-N2217	Rotundic acid	Inhibitor	99.41%	Unkown
HY-N1050	Zederone	Inhibitor	99.61%	Unkown
HY-13806	XL388	Inhibitor	99.74%	Unkown
HY-163198	ASCT2-IN-1	Inhibitor	98.21%	Unkown
HY-107363	FT-1518	Inhibitor	98.62%	Unkown
HY-15271	WYE-687	Inhibitor	98.05%	Unkown
HY-124582	NEO214	Activator	≥98.0%	Unkown
HY-12652	AZD3147	Inhibitor	99.93%	Unkown
HY-162382	KTC1101	Inhibitor	98.09%	Unkown
HY-122665	HTH-01-091	Inhibitor	98.64%	Unkown
HY-101776A	Desmethyl-VS-5584 hydrochloride	Inhibitor	98.63%	Unkown
HY-10219GL	Rapamycin (GMP Like)	Inhibitor	98.8%	Unkown
HY-N9942	Physalin A	Inhibitor	99.22%	Unkown
HY-143510	RMC-4627		99.20%	Unkown
HY-125927	8-Aminoadenosine	Inhibitor	99.94%	Unkown
HY-141805	MHY-1685	Inhibitor	99.84%	Unkown
HY-W348485	WRX606	Inhibitor	95.65%	Unkown
HY-145931	CC214-2	Inhibitor	98.41%	Unkown
HY-10812	GNE-490	Inhibitor	96.29%	Unkown
HY-134903	(32-Carbonyl)-RMC-5552	Inhibitor	95.41%	Unkown
HY-N2590	Lupenone		99.74%	Unkown
HY-N2303	Eriocalyxin B	Inhibitor	99.93%	Unkown
HY-171047	Autophagy inducer 7	Inhibitor	/	Unkown
HY-114267	Cbz-B3A	Inhibitor	≥98.0%	Unkown
HY-153120A	PI3K/mTOR Inhibitor-13 sodium	Inhibitor	98.13%	Unkown
HY-111065	OXA-01	Inhibitor	/	Unkown
HY-147284	PI3K-IN-37	Inhibitor	≥99.0%	Unkown
HY-N0486S12	L-Leucine-d2	Activator	≥99.0%	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	98.19%	Unkown
HY-N4315	Pomiferin	Inhibitor	98.98%	Unkown
HY-N3628	Coronarin A	Inhibitor	≥98.0%	Unkown
HY-157169	IBL-302	Inhibitor	98.21%	Unkown
HY-155066	FD274	Inhibitor	99.45%	Unkown
HY-118712	mTOR inhibitor WYE-23	Inhibitor	/	Unkown
HY-15271A	WYE-687 dihydrochloride	Inhibitor	≥98.0%	Unkown
HY-162143	SKI-349	Inhibitor	99.58%	Unkown
HY-P1823	C-Reactive Protein (CRP) (174-185)	Modulator	99.88%	Unkown
HY-10620	PI3K-IN-22	Inhibitor	99.50%	Unkown
HY-109633	PI3K-IN-18	Inhibitor	≥99.0%	Unkown
HY-122665A	HTH-01-091 TFA	Inhibitor	99.48%	Unkown
HY-P3072	Mastoparan 17	Control	98.15%	Unkown
HY-N5136	25(R,S)-Ruscogenin	Inhibitor	99.83%	Unkown
HY-10219S1	Rapamycin-13C,d3	Inhibitor	97.05%	Unkown
HY-U00326	PI3Kα/mTOR-IN-1	Inhibitor	99.30%	Unkown
HY-151137	HSP90/mTOR-IN-1	Inhibitor	/	Unkown
HY-112602	PI3K/mTOR Inhibitor-1	Inhibitor	/	Unkown
HY-111370	mTOR inhibitor-2	Inhibitor	/	Unkown
HY-10218S	Everolimus-d4	Inhibitor	97.88%	Unkown
HY-N0486S4	L-Leucine-d7	Activator	/	Unkown
HY-170670	DQ661	Inhibitor	/	Unkown
HY-147613	PI3K/mTOR Inhibitor-6	Inhibitor	/	Unkown
HY-162993	HN2210	Inhibitor	/	Unkown
HY-147913	PI3K/Akt/mTOR-IN-3	Inhibitor	/	Unkown
HY-15901	LGB321	Inhibitor	/	Unkown
HY-N0486S10	L-Leucine-18O2	Activator	/	Unkown
HY-162147	Nur77 modulator 3	Inhibitor	99.01%	Unkown
HY-144295	PI3Kα-IN-5	Inhibitor	/	Unkown
HY-173141	mTOR inhibitor-26	Inhibitor	/	Unkown
HY-147285	PI3K/mTOR Inhibitor-9	Inhibitor	/	Unkown
HY-N0109R	Salidroside (Standard)	Activator	/	Unkown
HY-N0486S11	L-Leucine-d1	Activator	/	Unkown
HY-169407	AKT-IN-24	Inhibitor	/	Unkown
HY-N0486S7	L-Leucine-1-13C,15N	Activator	≥98.0%	Unkown
HY-W339757	Dioctanoylphosphatidic acid sodium		/	Unkown
HY-170912	Topo I/II-IN-2	Inhibitor	/	Unkown
HY-154910	CC214-1	Inhibitor	/	Unkown
HY-141476	PI3K/mTOR Inhibitor-3	Inhibitor	/	Unkown
HY-169100	Antiproliferative agent-57		/	Unkown
HY-172175	HYS-072	Inhibitor	/	Unkown
HY-15269	PP30	Inhibitor	/	Unkown
HY-10116	PI-540	Inhibitor	/	Unkown
HY-101955	(2S,6S)-Hydroxynorketamine hydrochloride	Activator	/	Unkown
HY-15901A	LGB321 monohydrochloride	Inhibitor	/	Unkown
HY-RS08810	MTOR Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-155376	mTOR inhibitor-14	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-P5984A	Thioether-cyclized helix B peptide, CHBP TFA	Inhibitor	/	Unkown
HY-150061	NVP-BBD130	Inhibitor	/	Unkown
HY-153120	PI3K/mTOR Inhibitor-13	Inhibitor	/	Unkown
HY-123849	SN32976	Inhibitor	/	Unkown
HY-137996	Dehydrovomifoliol	Inhibitor	/	Unkown
HY-172259	Toyaburgine	Inhibitor	/	Unkown
HY-161856	Antifungal agent 106	Inhibitor	/	Unkown
HY-N6626R	Pyraclostrobin (Standard)		/	Unkown
HY-168609	CRI9	Inhibitor	/	Unkown
HY-127067	Yuanhuadin	Inhibitor	/	Unkown
HY-163511	PI3K/Akt/mTOR-IN-4	Inhibitor	/	Unkown
HY-152238	PI3K/mTOR Inhibitor-12	Inhibitor	/	Unkown
HY-N0486S13	L-Leucine-15N,d10		/	Unkown
HY-146016	PI3K/mTOR Inhibitor-5	Inhibitor	/	Unkown
HY-151915	ATR-IN-20	Inhibitor	/	Unkown
HY-147614	PI3K/mTOR Inhibitor-7	Inhibitor	/	Unkown
HY-13610	N1,N11-Diethylnorspermine	Inhibitor	/	Unkown
HY-128027	eCF309	Inhibitor	98.2%	Unkown
HY-156432	ALK-IN-26	Inhibitor	99.87%	Unkown
HY-168893	K882	Inhibitor	/	Unkown
HY-170405	YB-3–17	Inhibitor	/	Unkown
HY-N1338	Royleanone	Inhibitor	/	Unkown
HY-N12124	Monascuspiloin	Inhibitor	/	Unkown
HY-160548	mTOR inhibitor-18	Inhibitor	/	Unkown
HY-N0486S5	L-Leucine-2-13C	Activator	/	Unkown
HY-15281	QL-IX-55	Inhibitor	/	Unkown
HY-15268	PP487	Inhibitor	/	Unkown
HY-161509	PT-88	Inhibitor	/	Unkown
HY-101776	Desmethyl-VS-5584	Inhibitor	/	Unkown
HY-13847	GNE-555	Inhibitor	/	Unkown
HY-N0486S6	L-Leucine-2-13C,15N	Activator	/	Unkown
HY-168884	AV457	Inhibitor	/	Unkown
HY-155721	22-(4′-py)-JA	Inhibitor	/	Unkown
HY-172678	PUC-10	Inhibitor	/	Unkown
HY-168919	KRASG12C IN-16	Inhibitor	/	Unkown
HY-144449	mTOR/HDAC6-IN-1	Inhibitor	/	Unkown
HY-RS08812	Mtor Rat Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-169121	DA-143	Inhibitor	/	Unkown
HY-108959	D-87503	Inhibitor	/	Unkown
HY-161857	Akt/mTOR-IN-1	Inhibitor	/	Unkown
HY-N1244	Sarmentosin	Inhibitor	/	Unkown
HY-144687	ATM Inhibitor-4	Inhibitor	/	Unkown
HY-159517	PI3K/Akt/mTOR-IN-5	Inhibitor	/	Unkown
HY-113038	D-α-Hydroxyglutaric acid	Inhibitor	/	Unkown
HY-115869	RMC-4529	Inhibitor	/	Unkown
HY-RS08811	Mtor Mouse Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-159577	Nic-15	Modulator	/	Unkown
HY-N2517	Dihydroevocarpine	Inhibitor	99.62%	Unkown
HY-18953	mTOR inhibitor-23	Inhibitor	/	Unkown
HY-168333	5-HT6 inverse agonist 1	Inhibitor	/	Unkown
HY-156445	PI3K/mTOR Inhibitor-14	Inhibitor	/	Unkown
HY-154957	mTOR inhibitor-11	Inhibitor	/	Unkown
HY-170656	PI3K/mTOR Inhibitor-17	Inhibitor	/	Unkown
HY-141701	mTOR/HDAC-IN-1	Inhibitor	/	Unkown
HY-N10754	Aschantin	Inhibitor	/	Unkown
HY-154958	mTOR inhibitor-12	Inhibitor	/	Unkown
HY-144686	ATM Inhibitor-3	Inhibitor	/	Unkown
HY-118704	P-2281	Inhibitor	99.81%	Unkown
HY-125535	OSU-53	Inhibitor	/	Unkown
HY-146200	PI3K/mTOR Inhibitor-8	Inhibitor	/	Unkown
HY-169022	4-FPBUA	Inhibitor	/	Unkown
HY-P5984	Thioether-cyclized helix B peptide, CHBP	Inhibitor	/	Unkown
HY-139832	MCX 28	Inhibitor	/	Unkown
HY-P10323	T7 Peptide	Inhibitor	/	Unkown
HY-121726	3HOI-BA-01	Inhibitor	/	Unkown
HY-137315S	TML-6-d3		/	Unkown
HY-169960	2DII	Inhibitor	/	Unkown
HY-162023	mTOR inhibitor-10	Inhibitor	/	Unkown
HY-164385	NSC126405	Inhibitor	/	Unkown
HY-116191	WJD008	Inhibitor	/	Unkown
HY-112903A	YW3-56 hydrochloride	Inhibitor	/	Unkown
HY-155475	mTORC1-IN-2	Inhibitor	/	Unkown
HY-164384	DFX117	Inhibitor	/	Unkown
HY-10218S1	Everolimus-13C2,d4	Inhibitor	/	Unkown
HY-50673A	Dactolisib hydrochloride	Inhibitor	/	Unkown
HY-N13176	Stellettin B	Inhibitor	/	Unkown
HY-N0112S	Dihydromyricetin-d4	Inhibitor	/	Unkown
HY-W019868	1-O-Hexadecyl-2-O-acetyl-sn-glycerol	Inhibitor	/	Unkown
HY-162025	mTOR inhibitor-17	Inhibitor	/	Unkown
HY-W654330	Pyraclostrobin-d6		/	Unkown
HY-155211	mTOR inhibitor-13	Inhibitor	/	Unkown
HY-164662	mTOR inhibitor-24	Inhibitor	/	Unkown
HY-171229	1-Acetyl-DHAP	Substrate	/	Unkown
HY-N15267	Ovalitenone	Inhibitor	/	Unkown
HY-117923	PF-06465603	Inhibitor	/	Unkown
HY-162024	mTOR inhibitor-16	Inhibitor	/	Unkown
HY-W779800	D-α-Hydroxyglutaric acid-13C5 disodium	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mtor	NCBI	NCBI:2475

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