TAF3 - TATA-box binding protein associated factor 3 Gene

Homo sapiens

Also known as TAF140; TAFII140; TAFII-140

Gene ID: 83860 | Gene type: protein coding

About TAF3

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:7,818,505-8,016,631 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 5.8), ovary (RPKM 3.8) and 25 other tissues.

Summary

The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]

TAF3 Products(1)

mRNA	Protein	Name
NM_031923.4	NP_114129.1	transcription initiation factor TFIID subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11438666	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in maintenance of protein location in nucleus	IDA IDA: Inferred from direct assay	15870280	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18549481	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18549481	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15870280	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	11438666	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF3 Protein Structure

Bromo_TP

PHD

0
200
400
600
800
929 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor TFIID subunit 3

140 kDa TATA box-binding protein-associated factor

TAF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAF3	Q5VWG9	H3-3A	Homo sapiens	P84243	Pull Down	20953165
Intra	TAF3	Q5VWG9	TAF5	Homo sapiens	Q15542	Anti Tag CoIP	33961781
Intra	TAF3	Q5VWG9	TAF5	Homo sapiens	Q15542	Anti Tag CoIP	20953165

Cross: Cross-species interaction Intra: Intraspecies interaction

TAF3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81876	TAF3 Antibody (YA1621)	WB, IHC-P	Human

Related Diseases

Diseases

Alias

Lateral Meningocele Syndrome

Lehman Syndrome	Lms
LMNS	Meningocele, Lateral Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14168	TAF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TAF3	MGD	MGI:2388097
Felis catus	TAF3	VGNC	VGNC:65931
Macaca mulatta	TAF3	VGNC	VGNC:78147
Canis familiaris	TAF3	VGNC	VGNC:47081
Bos taurus	TAF3	VGNC	VGNC:35574
Rattus norvegicus	TAF3	RGD	RGD:2324594

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